naa a22 4500 510747272 CHVBK 20180411083051.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s11547-013-0932-0 doi (NATIONALLICENCE)springer-10.1007/s11547-013-0932-0 Stereotactic body radiotherapy for cardiac and paracardiac metastases: University of Florence experience [Elektronische Daten] [Pierluigi Bonomo, Lorenzo Livi, Andrea Rampini, Icro Meattini, Benedetta Agresti, Gabriele Simontacchi, Fabiola Paiar, Monica Mangoni, Ivano Bonucci, Daniela Greto, Laura Masi, Raffaella Doro, Livia Marrazzo, Giampaolo Biti] Radioterapia stereotassica extracranica per metastasi cardiache e paracardiache: esperienza dell'Università di Firenze Purpose: This study sought to evaluate acute toxicity and local control in patients who underwent extracranial stereotactic body radiation therapy (SBRT) for paracardiac and cardiac metastatic lesions, defined as such when located at a maximum distance of 1 cm from the heart or inside its parenchyma. Materials and methods: Between January 2009 and May 2011, 16 patients with paracardiac and cardiac lesions were treated with SBRT. For dose specification, in 15 of 16 patients, the prescription dosage was 36 Gy in three fractions (70% isodose). In one patient, the target lesion was inside the heart, and the prescription dosage was 30 Gy in three fractions (70% isodose). Results: Regarding response to stereotactic radiotherapy, we recorded one (6%) complete response (CR), six (37%) partial responses (PR), five (32%) stable disease (SD) and four (25%) local failures. Median interval to local failure was 5.2 (range, 3-12) months. The cause of death was distant progression of disease in all four patients. Compliance to treatment was excellent; no patient developed cardiological symptoms or electrocardiographic abnormalities, even months after SBRT. Conclusions: Results of our retrospective study indicate that SBRT represents a safe and effective treatment option for patients with cardiac and paracardiac metastases. Springer-Verlag Italia, 2013 Cardiac metastases nationallicence Paracardiac metastases nationallicence Oligometastases nationallicence Stereotactic body radiotherapy nationallicence Radiotherapy nationallicence Metastasi cardiache nationallicence Metastasi paracardiache nationallicence Oligometastasi nationallicence Radioterapia stereotassica nationallicence Radioterapia nationallicence Bonomo Pierluigi Santa Chiara Radiotherapy Unit, Florence University, Via di Barbiano 2A, 50129, Florence, Italy aut Livi Lorenzo Santa Chiara Radiotherapy Unit, Florence University, Via di Barbiano 2A, 50129, Florence, Italy aut Rampini Andrea Santa Chiara Radiotherapy Unit, Florence University, Via di Barbiano 2A, 50129, Florence, Italy aut Meattini Icro Azienda Ospedaliero Universitaria Careggi, Radiotherapy Unit, Florence University, Florence, Italy aut Agresti Benedetta Azienda Ospedaliero Universitaria Careggi, Radiotherapy Unit, Florence University, Florence, Italy aut Simontacchi Gabriele Azienda Ospedaliero Universitaria Careggi, Radiotherapy Unit, Florence University, Florence, Italy aut Paiar Fabiola Azienda Ospedaliero Universitaria Careggi, Radiotherapy Unit, Florence University, Florence, Italy aut Mangoni Monica Azienda Ospedaliero Universitaria Careggi, Radiotherapy Unit, Florence University, Florence, Italy aut Bonucci Ivano Santa Chiara Radiotherapy Unit, Florence University, Via di Barbiano 2A, 50129, Florence, Italy aut Greto Daniela Azienda Ospedaliero Universitaria Careggi, Radiotherapy Unit, Florence University, Florence, Italy aut Masi Laura Santa Chiara Radiotherapy Unit, Florence University, Via di Barbiano 2A, 50129, Florence, Italy aut Doro Raffaella Santa Chiara Radiotherapy Unit, Florence University, Via di Barbiano 2A, 50129, Florence, Italy aut Marrazzo Livia Azienda Ospedaliero Universitaria Careggi, Radiotherapy Unit, Florence University, Florence, Italy aut Biti Giampaolo Azienda Ospedaliero Universitaria Careggi, Radiotherapy Unit, Florence University, Florence, Italy aut La radiologia medica Springer Milan 118/6(2013-09-01), 1055-1065 0033-8362 118:6<1055 2013 118 11547 https://doi.org/10.1007/s11547-013-0932-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11547-013-0932-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bonomo Pierluigi Santa Chiara Radiotherapy Unit, Florence University, Via di Barbiano 2A, 50129, Florence, Italy aut NATIONALLICENCE 700 1- Livi Lorenzo Santa Chiara Radiotherapy Unit, Florence University, Via di Barbiano 2A, 50129, Florence, Italy aut NATIONALLICENCE 700 1- Rampini Andrea Santa Chiara Radiotherapy Unit, Florence University, Via di Barbiano 2A, 50129, Florence, Italy aut NATIONALLICENCE 700 1- Meattini Icro Azienda Ospedaliero Universitaria Careggi, Radiotherapy Unit, Florence University, Florence, Italy aut NATIONALLICENCE 700 1- Agresti Benedetta Azienda Ospedaliero Universitaria Careggi, Radiotherapy Unit, Florence University, Florence, Italy aut NATIONALLICENCE 700 1- Simontacchi Gabriele Azienda Ospedaliero Universitaria Careggi, Radiotherapy Unit, Florence University, Florence, Italy aut NATIONALLICENCE 700 1- Paiar Fabiola Azienda Ospedaliero Universitaria Careggi, Radiotherapy Unit, Florence University, Florence, Italy aut NATIONALLICENCE 700 1- Mangoni Monica Azienda Ospedaliero Universitaria Careggi, Radiotherapy Unit, Florence University, Florence, Italy aut NATIONALLICENCE 700 1- Bonucci Ivano Santa Chiara Radiotherapy Unit, Florence University, Via di Barbiano 2A, 50129, Florence, Italy aut NATIONALLICENCE 700 1- Greto Daniela Azienda Ospedaliero Universitaria Careggi, Radiotherapy Unit, Florence University, Florence, Italy aut NATIONALLICENCE 700 1- Masi Laura Santa Chiara Radiotherapy Unit, Florence University, Via di Barbiano 2A, 50129, Florence, Italy aut NATIONALLICENCE 700 1- Doro Raffaella Santa Chiara Radiotherapy Unit, Florence University, Via di Barbiano 2A, 50129, Florence, Italy aut NATIONALLICENCE 700 1- Marrazzo Livia Azienda Ospedaliero Universitaria Careggi, Radiotherapy Unit, Florence University, Florence, Italy aut NATIONALLICENCE 700 1- Biti Giampaolo Azienda Ospedaliero Universitaria Careggi, Radiotherapy Unit, Florence University, Florence, Italy aut NATIONALLICENCE 773 0- La radiologia medica Springer Milan 118/6(2013-09-01), 1055-1065 0033-8362 118:6<1055 2013 118 11547 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer