naa a22 4500 510747426 CHVBK 20180411083051.0 cr unu---uuuuu 180411e20131001xx s 000 0 eng 10.1007/s11547-013-0947-6 doi (NATIONALLICENCE)springer-10.1007/s11547-013-0947-6 Radiation therapy after breast reconstruction: outcomes, complications, and patient satisfaction [Elektronische Daten] [Alessia Carnevale, Claudia Scaringi, Giovanna Scalabrino, Barbara Campanella, Mattia Osti, Vitaliana De Sanctis, Maurizio Valeriani, Giuseppe Minniti, Claudio Amanti, Fabio Santanelli, Riccardo Enrici] Terapia radiante dopo ricostruzione mammaria: esiti, complicazioni e soddisfazione delle pazienti Purpose: The aim of this study was to evaluate treatmentrelated complications, outcomes, and patient satisfaction in women with locally advanced breast cancer who received post-mastectomy radiation therapy (PMRT) after breast reconstruction (BR). Materials and methods: Between October 2007 and November 2010, 46 patients with locally advanced breast cancer who underwent mastectomy followed by BR received PMRT at our Department. Radiotherapy was delivered to the chest wall with a dose of 50 Gy in 25 fractions over 5 weeks. Results: The median follow-up was 19 months. Skin erythema grade 1 and 2 was seen in 44 (96%) and two (4%) patients, respectively. Major complications, requiring additional corrective surgical procedure, occurred in three (7%) patients (one patient with prosthesis, one patient with tissue expander and one patient with deep inferior epigastric perforator flap). At univariate analysis, smoking, chemotherapy, hormone therapy with tamoxifen and reconstruction with implant were associated with overall complications (capsular contracture and reconstruction failure). Forty (86%) patients were very satisfied or satisfied with the cosmetic outcome of reconstruction. Conclusions: Radiotherapy can be safely delivered after BR, with a low complication rate and good patient satisfaction. Further randomised studies are needed to better define the optimal timing of breast reconstruction and post-mastectomy radiation therapy. Springer-Verlag, 2013 Breast cancer nationallicence Breast reconstruction nationallicence Postmastectomy radiation therapy nationallicence Tumore della mammella nationallicence Ricostruzione mammaria nationallicence Radioterapia post-mastectomia nationallicence Carnevale Alessia Department of Radiation Oncology, S. Andrea Hospital, University "Sapienza”, Via di Grottarossa 1035, 00189, Rome, Italy aut Scaringi Claudia Department of Radiation Oncology, S. Andrea Hospital, University "Sapienza”, Via di Grottarossa 1035, 00189, Rome, Italy aut Scalabrino Giovanna Department of Radiation Oncology, S. Andrea Hospital, University "Sapienza”, Via di Grottarossa 1035, 00189, Rome, Italy aut Campanella Barbara Department of Radiation Oncology, S. Andrea Hospital, University "Sapienza”, Via di Grottarossa 1035, 00189, Rome, Italy aut Osti Mattia Department of Radiation Oncology, S. Andrea Hospital, University "Sapienza”, Via di Grottarossa 1035, 00189, Rome, Italy aut De Sanctis Vitaliana Department of Radiation Oncology, S. Andrea Hospital, University "Sapienza”, Via di Grottarossa 1035, 00189, Rome, Italy aut Valeriani Maurizio Department of Radiation Oncology, S. Andrea Hospital, University "Sapienza”, Via di Grottarossa 1035, 00189, Rome, Italy aut Minniti Giuseppe Department of Radiation Oncology, S. Andrea Hospital, University "Sapienza”, Via di Grottarossa 1035, 00189, Rome, Italy aut Amanti Claudio Operative Breast Surgery Unit, S. Andrea Hospital, University "Sapienza”, Rome, Italy aut Santanelli Fabio Plastic Surgery Unit, S. Andrea Hospital, University "Sapienza”, Rome, Italy aut Enrici Riccardo Department of Radiation Oncology, S. Andrea Hospital, University "Sapienza”, Via di Grottarossa 1035, 00189, Rome, Italy aut La radiologia medica Springer-Verlag 118/7(2013-10-01), 1240-1250 0033-8362 118:7<1240 2013 118 11547 https://doi.org/10.1007/s11547-013-0947-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11547-013-0947-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Carnevale Alessia Department of Radiation Oncology, S. Andrea Hospital, University "Sapienza”, Via di Grottarossa 1035, 00189, Rome, Italy aut NATIONALLICENCE 700 1- Scaringi Claudia Department of Radiation Oncology, S. Andrea Hospital, University "Sapienza”, Via di Grottarossa 1035, 00189, Rome, Italy aut NATIONALLICENCE 700 1- Scalabrino Giovanna Department of Radiation Oncology, S. Andrea Hospital, University "Sapienza”, Via di Grottarossa 1035, 00189, Rome, Italy aut NATIONALLICENCE 700 1- Campanella Barbara Department of Radiation Oncology, S. Andrea Hospital, University "Sapienza”, Via di Grottarossa 1035, 00189, Rome, Italy aut NATIONALLICENCE 700 1- Osti Mattia Department of Radiation Oncology, S. Andrea Hospital, University "Sapienza”, Via di Grottarossa 1035, 00189, Rome, Italy aut NATIONALLICENCE 700 1- De Sanctis Vitaliana Department of Radiation Oncology, S. Andrea Hospital, University "Sapienza”, Via di Grottarossa 1035, 00189, Rome, Italy aut NATIONALLICENCE 700 1- Valeriani Maurizio Department of Radiation Oncology, S. Andrea Hospital, University "Sapienza”, Via di Grottarossa 1035, 00189, Rome, Italy aut NATIONALLICENCE 700 1- Minniti Giuseppe Department of Radiation Oncology, S. Andrea Hospital, University "Sapienza”, Via di Grottarossa 1035, 00189, Rome, Italy aut NATIONALLICENCE 700 1- Amanti Claudio Operative Breast Surgery Unit, S. Andrea Hospital, University "Sapienza”, Rome, Italy aut NATIONALLICENCE 700 1- Santanelli Fabio Plastic Surgery Unit, S. Andrea Hospital, University "Sapienza”, Rome, Italy aut NATIONALLICENCE 700 1- Enrici Riccardo Department of Radiation Oncology, S. Andrea Hospital, University "Sapienza”, Via di Grottarossa 1035, 00189, Rome, Italy aut NATIONALLICENCE 773 0- La radiologia medica Springer-Verlag 118/7(2013-10-01), 1240-1250 0033-8362 118:7<1240 2013 118 11547 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer