naa a22 4500 510747671 CHVBK 20180411083052.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s11547-012-0870-2 doi (NATIONALLICENCE)springer-10.1007/s11547-012-0870-2 Diagnostic accuracy and agreement between whole-body diffusion MRI and bone scintigraphy in detecting bone metastases [Elektronische Daten] [A. Stecco, M. Lombardi, L. Leva, M. Brambilla, E. Negru, S. Delli Passeri, A. Carriero] Accuratezza diagnostica e concordanza tra diffusione whole-body e scintigrafia ossea nell'identificazione delle metastasi ossee Purpose: This study was done to determine the diagnostic value of whole-body magnetic resonance using diffusion-weighted imaging with background suppression (WB-DWIBS) for detecting bone metastases compared with whole-body bone scintigraphy (WB-BS). Materials and methods: Twenty-three patients with solid tumours underwent both WB-DWIBS imaging and WBBS. A nuclear medicine specialist interpreted WB-BS images and two blinded radiologists, first independently and then jointly, interpreted the WB-DWIBS images by completing a reading grid categorising the skeletal segments. Cohen's k statistic was used to determine interobserver agreement in reading the WB-DWIBS images and the agreement between WB-BS and WB-DWIBS. Sensitivity and specificity were calculated per patient and per lesion. Results: Interobserver agreement in reading the WBDWIBS images was substantial or good, with κ=0.68. Analysis of agreement between the nuclear physician's and the radiologists' readings provided κ=0.87 [95% confidence interval (CI)=0.76-0.98)] Per-lesion analysis gave a sensitivity of 80% (95% CI=75-85) and a specificity of 98.2% (95% CI=96.5-99.8). Conclusions: We found a good level of interobserver agreement for the WB-DWIBS images and an excellent level of agreement in the subjective judgement of presence or absence of disease between WB-BS and WB-DWIBS after consensual double reading. WB-DWIBS has the same specificity as WB-BS in detecting bone metastases. The anatomical sites exhibiting the highest level of disagreement between WB-DWIBS and WB-BS are the pelvis, the coccyx, and the sternum, all sites at which detection with WB-BS has the greatest limitations. Springer-Verlag Italia, 2012 Magnetic resonance-DWIBS nationallicence Bone metastasis nationallicence Scintigraphy nationallicence Risonanza magnetica-DWIBS nationallicence Metastasi ossee nationallicence Scintigrafia nationallicence Stecco A. SCDU Radiologia, AOU Maggiore della Carità, Università del Piemonte Orientale A. Avogadro, C.so Mazzini 18, 28100, Novara, Italy aut Lombardi M. SCDU Radiologia, AOU Maggiore della Carità, Università del Piemonte Orientale A. Avogadro, C.so Mazzini 18, 28100, Novara, Italy aut Leva L. SCDU Medicina Nucleare, AOU Maggiore della Carità, Università del Piemonte Orientale A. Avogadro, Novara, Italy aut Brambilla M. SDO Fisica Sanitaria, AOU Maggiore della Carità, Novara, Italy aut Negru E. SCDU Oncologia, AOU Maggiore della Carità, Università del Piemonte Orientale A. Avogadro, Novara, Italy aut Delli Passeri S. SCDU Radiologia, AOU Maggiore della Carità, Università del Piemonte Orientale A. Avogadro, C.so Mazzini 18, 28100, Novara, Italy aut Carriero A. SCDU Radiologia, AOU Maggiore della Carità, Università del Piemonte Orientale A. Avogadro, C.so Mazzini 18, 28100, Novara, Italy aut La radiologia medica Springer Milan 118/3(2013-04-01), 465-475 0033-8362 118:3<465 2013 118 11547 https://doi.org/10.1007/s11547-012-0870-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11547-012-0870-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Stecco A. SCDU Radiologia, AOU Maggiore della Carità, Università del Piemonte Orientale A. Avogadro, C.so Mazzini 18, 28100, Novara, Italy aut NATIONALLICENCE 700 1- Lombardi M. SCDU Radiologia, AOU Maggiore della Carità, Università del Piemonte Orientale A. Avogadro, C.so Mazzini 18, 28100, Novara, Italy aut NATIONALLICENCE 700 1- Leva L. SCDU Medicina Nucleare, AOU Maggiore della Carità, Università del Piemonte Orientale A. Avogadro, Novara, Italy aut NATIONALLICENCE 700 1- Brambilla M. SDO Fisica Sanitaria, AOU Maggiore della Carità, Novara, Italy aut NATIONALLICENCE 700 1- Negru E. SCDU Oncologia, AOU Maggiore della Carità, Università del Piemonte Orientale A. Avogadro, Novara, Italy aut NATIONALLICENCE 700 1- Delli Passeri S. SCDU Radiologia, AOU Maggiore della Carità, Università del Piemonte Orientale A. Avogadro, C.so Mazzini 18, 28100, Novara, Italy aut NATIONALLICENCE 700 1- Carriero A. SCDU Radiologia, AOU Maggiore della Carità, Università del Piemonte Orientale A. Avogadro, C.so Mazzini 18, 28100, Novara, Italy aut NATIONALLICENCE 773 0- La radiologia medica Springer Milan 118/3(2013-04-01), 465-475 0033-8362 118:3<465 2013 118 11547 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer