naa a22 4500 510747698 CHVBK 20180411083052.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s11547-012-0867-x doi (NATIONALLICENCE)springer-10.1007/s11547-012-0867-x Treatment of invasive male breast cancer: a 40-year single-institution experience [Elektronische Daten] [Icro Meattini, L. Livi, D. Franceschini, C. Saieva, V. Scotti, D. Casella, V. Criscenti, I. Zanna, F. Meacci, E. Gerlain, B. Agresti, M. Mangoni, F. Paiar, G. Simontacchi, D. Greto, J. Nori, S. Bianchi, L. Cataliotti, G. Biti] Il trattamento del carcinoma mammario invasivo maschile: 40 anni di esperienza in un singolo centro Purpose: We conducted a retrospective analysis to evaluate the management and outcome of invasive male breast cancer treated in a single-institution over a period of 40 years. Materials and methods: We reviewed the clinical and pathological features of 60 male patients affected by breast carcinoma treated at our Radiotherapy Unit between 1971 and 2011. Tumours were classified according to histological type and the updated 2010 TNM classification of malignant tumours. Results: At a median follow-up of 8.9 [range, 0.6-20; standard deviation (SD), 4.98] years, 32 patients (53.3%) were alive and 16 patients died (26.7%) due to disease progression and 12 (20%) due to other causes. At univariate analysis for overall survival, pathological tumour size (p=0.031), histological subtype (p=0.013) and nodal status (p=0.006) emerged as significant predictors of death. At multivariate analysis, independent death predictors were advanced pathological tumour size (p=0.016), positive nodal status (p=0.003) and invasive cribriform histological type (p=0.0003). Conclusions: In consideration of the rarity of the disease, many issues are still being debated, and future collaborative studies are required. However, our experience confirms the prognostic role of greater pathological tumour size and positive nodal status as unfavourable features for survival in male breast cancer. Springer-Verlag Italia, 2012 Male breast cancer nationallicence Prognostic factors nationallicence Surgery nationallicence Mastectomy nationallicence Breast-conserving surgery nationallicence Radiotherapy nationallicence Carcinoma mammario maschile nationallicence Fattori prognostici nationallicence Chirurgia nationallicence Mastectomia nationallicence Chirurgia conservative della mammella nationallicence Radioterapia nationallicence Meattini Icro Radiotherapy Unit, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy aut Livi L. Radiotherapy Unit, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy aut Franceschini D. Radiotherapy Unit, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy aut Saieva C. Molecular and Nutritional Epidemiology Unit, ISPO (Cancer Research and Prevention Institute), University of Florence, Florence, Italy aut Scotti V. Radiotherapy Unit, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy aut Casella D. Department of Surgery, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy aut Criscenti V. Department of Surgery, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy aut Zanna I. Molecular and Nutritional Epidemiology Unit, ISPO (Cancer Research and Prevention Institute), University of Florence, Florence, Italy aut Meacci F. Radiotherapy Unit, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy aut Gerlain E. Molecular and Nutritional Epidemiology Unit, ISPO (Cancer Research and Prevention Institute), University of Florence, Florence, Italy aut Agresti B. Radiotherapy Unit, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy aut Mangoni M. Radiotherapy Unit, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy aut Paiar F. Radiotherapy Unit, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy aut Simontacchi G. Radiotherapy Unit, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy aut Greto D. Radiotherapy Unit, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy aut Nori J. Diagnostic Senology Unit, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy aut Bianchi S. Division of Pathological Anatomy, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy aut Cataliotti L. Department of Surgery, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy aut Biti G. Radiotherapy Unit, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy aut La radiologia medica Springer Milan 118/3(2013-04-01), 476-486 0033-8362 118:3<476 2013 118 11547 https://doi.org/10.1007/s11547-012-0867-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11547-012-0867-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Meattini Icro Radiotherapy Unit, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy aut NATIONALLICENCE 700 1- Livi L. Radiotherapy Unit, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy aut NATIONALLICENCE 700 1- Franceschini D. Radiotherapy Unit, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy aut NATIONALLICENCE 700 1- Saieva C. Molecular and Nutritional Epidemiology Unit, ISPO (Cancer Research and Prevention Institute), University of Florence, Florence, Italy aut NATIONALLICENCE 700 1- Scotti V. Radiotherapy Unit, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy aut NATIONALLICENCE 700 1- Casella D. Department of Surgery, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy aut NATIONALLICENCE 700 1- Criscenti V. Department of Surgery, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy aut NATIONALLICENCE 700 1- Zanna I. Molecular and Nutritional Epidemiology Unit, ISPO (Cancer Research and Prevention Institute), University of Florence, Florence, Italy aut NATIONALLICENCE 700 1- Meacci F. Radiotherapy Unit, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy aut NATIONALLICENCE 700 1- Gerlain E. Molecular and Nutritional Epidemiology Unit, ISPO (Cancer Research and Prevention Institute), University of Florence, Florence, Italy aut NATIONALLICENCE 700 1- Agresti B. Radiotherapy Unit, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy aut NATIONALLICENCE 700 1- Mangoni M. Radiotherapy Unit, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy aut NATIONALLICENCE 700 1- Paiar F. Radiotherapy Unit, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy aut NATIONALLICENCE 700 1- Simontacchi G. Radiotherapy Unit, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy aut NATIONALLICENCE 700 1- Greto D. Radiotherapy Unit, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy aut NATIONALLICENCE 700 1- Nori J. Diagnostic Senology Unit, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy aut NATIONALLICENCE 700 1- Bianchi S. Division of Pathological Anatomy, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy aut NATIONALLICENCE 700 1- Cataliotti L. Department of Surgery, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy aut NATIONALLICENCE 700 1- Biti G. Radiotherapy Unit, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy aut NATIONALLICENCE 773 0- La radiologia medica Springer Milan 118/3(2013-04-01), 476-486 0033-8362 118:3<476 2013 118 11547 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer