naa a22 4500 510747809 CHVBK 20180411083053.0 cr unu---uuuuu 180411e20130601xx s 000 0 ita 10.1007/s11547-012-0901-z doi (NATIONALLICENCE)springer-10.1007/s11547-012-0901-z Diagnosi di vasculite dei grandi vasi con 18F-FDG PET-TC [Elektronische Daten] [U. Rozzanigo, A. Pellegrin, M. Centonze, G. Casagranda, M. Erini, D. Donner] Diagnosis of large-vessel vasculitis using [18F]-FDG PET-CT Purpose: The aim of this retrospective study was to assess the performance of fluorine-18 fluorodeoxyglucose positron emission tomography-computed tomography ([18F]-FDG PET-CT) for diagnosing large-vessel vasculitis (LVV) for a subset of patients at increased risk of rheumatic/immune diseases, taking into account concurrent immunosuppressive therapy. Materials and methods: The study comprised 64 rheumatological referrals with suspected LVV; half of the patients were on immunosuppressive therapy at the time of examination. The final diagnosis of LVV was established in 31 patients. To evaluate vascular uptake, the nuclear medicine physician employed both a semiquantitative method based on standardised uptake value (SUV) determination and a qualitative method based on a visual score from 0 to 3 on the maximum intensity projection (MIP) reformats. Finally, a joint assessment was carried out between the nuclear medicine physician and the reporting radiologist, in which PET metabolic data were re-evaluated taking into account clinical data and baseline CT scans. McNemar's test was used to compare four types of analysis: semiquantitative (cutoff ≥2.4), qualitative with standard cutoff (grade ≥2), qualitative with reduced cutoff (grade ≥1) and joint. Results: Semiquantitative analysis (sensitivity 74.19%, specificity 78.78%, accuracy 76.56%) and qualitative analysis with standard cutoff (sensitivity 64.51%, specificity 84.84%, accuracy 75.00%) showed no statistical difference for the diagnosis of LVV, whereas qualitative analysis with lower cutoff (sensitivity 93.54%, specificity 75.75%, accuracy 84.37%) proved to be better than the other two. Joint analysis (sensitivity 93.54%, specificity 93.93%, accuracy 93.75%) introduced some corrective elements not present in the qualitative analysis with cutoff ≥1 and therefore increased specificity significantly. Conclusions: Interpretation of PET-CT should be individualised for each patient by taking into account clinical-radiological and metabolic data. To this end, cooperation between the nuclear medicine specialist and the radiologist is essential. Springer-Verlag Italia, 2012 Large-vessel vasculitis nationallicence [18F]-FDG PET-CT nationallicence Aortitis nationallicence Giant cell arteritis nationallicence Takayasu's arteritis nationallicence Vasculite dei grandi vasi nationallicence 18F-FDG PET-TC nationallicence Aortite nationallicence Arterite gigantocellulare nationallicence Arterite di Takayasu nationallicence Rozzanigo U. Dipartimento di Radiodiagnostica, APSS di Trento, Trento, Italy aut Pellegrin A. Dipartimento di Radiodiagnostica, APSS di Trento, Trento, Italy aut Centonze M. Dipartimento di Radiodiagnostica, APSS di Trento, Trento, Italy aut Casagranda G. Dipartimento di Radiodiagnostica, APSS di Trento, Trento, Italy aut Erini M. Medicina Nucleare, Ospedale Santa Chiara, Largo Medaglie d'Oro 9, 38122, Trento, Italy aut Donner D. Medicina Nucleare, Ospedale Santa Chiara, Largo Medaglie d'Oro 9, 38122, Trento, Italy aut La radiologia medica Springer Milan 118/4(2013-06-01), 633-647 0033-8362 118:4<633 2013 118 11547 https://doi.org/10.1007/s11547-012-0901-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11547-012-0901-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rozzanigo U. Dipartimento di Radiodiagnostica, APSS di Trento, Trento, Italy aut NATIONALLICENCE 700 1- Pellegrin A. Dipartimento di Radiodiagnostica, APSS di Trento, Trento, Italy aut NATIONALLICENCE 700 1- Centonze M. Dipartimento di Radiodiagnostica, APSS di Trento, Trento, Italy aut NATIONALLICENCE 700 1- Casagranda G. Dipartimento di Radiodiagnostica, APSS di Trento, Trento, Italy aut NATIONALLICENCE 700 1- Erini M. Medicina Nucleare, Ospedale Santa Chiara, Largo Medaglie d'Oro 9, 38122, Trento, Italy aut NATIONALLICENCE 700 1- Donner D. Medicina Nucleare, Ospedale Santa Chiara, Largo Medaglie d'Oro 9, 38122, Trento, Italy aut NATIONALLICENCE 773 0- La radiologia medica Springer Milan 118/4(2013-06-01), 633-647 0033-8362 118:4<633 2013 118 11547 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer