naa a22 4500 51074785X CHVBK 20180411083053.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s11547-012-0909-4 doi (NATIONALLICENCE)springer-10.1007/s11547-012-0909-4 Neoadjuvant oxaliplatin and 5-fluorouracil with concurrent radiotherapy in patients with locally advanced rectal cancer: a singleinstitution experience [Elektronische Daten] [D. Greto, F. Paiar, C. Saieva, A. Galardi, M. Mangoni, L. Livi, B. Agresti, D. Franceschini, P. Bonomo, V. Scotti, B. Detti, F. Tonelli, A. Valeri, L. Messerini, G. Biti] Radioterapia neoadiuvante associata ad oxaliplatino e 5-fluorouracile in pazienti affetti da tumore rettale localmente avanzato: l'esperienza di un singolo centro Purpose: The aim of this study was to evaluate the rate of pathological response (PR), disease control and safety of neoadjuvant chemotherapy using oxaliplatin (OX) and 5-fluorouracil (5-FU) with concurrent radiotherapy for treating locally advanced rectal cancer. Materials and methods: Between November 2002 and December 2010, 90 patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy (CRT) were retrospectively analysed. All patients underwent preoperative radiotherapy (45 Gy in 1.8-Gy fractions) with concurrent OX (80 mg/m2 i.v., day 1) and a 120-h continuous infusion of 5-FU (1,000 mg/m2 per day). Surgery was performed within 6 weeks after completion of CRT treatment. Results: Complete pathological response was obtained in six patients (6.7%), and 39 (43.3%) had their disease downstaged. The median follow-up period was 4.7 years (6 months to 9 years). Local recurrence occurred in two patients (2.2%), one of whom developed also liver metastases. Distant metastases not associated with local relapse occurred in 23 (25.6%) patients. Overall (OS) and disease-free (DFS) survival were 62.9% and 52.8%, respectively. CRT was well tolerated, with only one grade 3 (1.2%) haematological toxicity (neutropaenia). Conclusions: Neoadjuvant systemic chemotherapy based on OX and 5-UC associated with radiotherapy is well tolerated, with good results in terms of pathological response, disease control and survival, in rectal cancer patients. Springer-Verlag Italia, 2013 Locally advanced rectal cancer nationallicence Chemoradiotherapy nationallicence Oxaliplatin nationallicence 5-Fluorouracil nationallicence Tumore del retto localmente avanzato nationallicence Radio-chemioterapia nationallicence Oxaliplatino nationallicence 5-fluorouracile nationallicence Greto D. Radiotherapy Unit, University of Florence, Viale Morgagni 85, 50134, Florence, Italy aut Paiar F. Radiotherapy Unit, University of Florence, Viale Morgagni 85, 50134, Florence, Italy aut Saieva C. Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Center, Scientific Institute of Tuscany, Florence, Italy aut Galardi A. Radiotherapy Unit, University of Florence, Viale Morgagni 85, 50134, Florence, Italy aut Mangoni M. Radiotherapy Unit, University of Florence, Viale Morgagni 85, 50134, Florence, Italy aut Livi L. Radiotherapy Unit, IFCA, University of Florence, Florence, Italy aut Agresti B. Radiotherapy Unit, University of Florence, Viale Morgagni 85, 50134, Florence, Italy aut Franceschini D. Radiotherapy Unit, University of Florence, Viale Morgagni 85, 50134, Florence, Italy aut Bonomo P. Radiotherapy Unit, IFCA, University of Florence, Florence, Italy aut Scotti V. Radiotherapy Unit, University of Florence, Viale Morgagni 85, 50134, Florence, Italy aut Detti B. Radiotherapy Unit, University of Florence, Viale Morgagni 85, 50134, Florence, Italy aut Tonelli F. Department of Surgery, University of Florence, Viale Morgagni 85, 50134, Florence, Italy aut Valeri A. Department of Surgery, University of Florence, Viale Morgagni 85, 50134, Florence, Italy aut Messerini L. Department of Pathology, University of Florence, Viale Morgagni 85, 50134, Florence, Italy aut Biti G. Radiotherapy Unit, University of Florence, Viale Morgagni 85, 50134, Florence, Italy aut La radiologia medica Springer Milan 118/4(2013-06-01), 570-582 0033-8362 118:4<570 2013 118 11547 https://doi.org/10.1007/s11547-012-0909-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11547-012-0909-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Greto D. Radiotherapy Unit, University of Florence, Viale Morgagni 85, 50134, Florence, Italy aut NATIONALLICENCE 700 1- Paiar F. Radiotherapy Unit, University of Florence, Viale Morgagni 85, 50134, Florence, Italy aut NATIONALLICENCE 700 1- Saieva C. Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Center, Scientific Institute of Tuscany, Florence, Italy aut NATIONALLICENCE 700 1- Galardi A. Radiotherapy Unit, University of Florence, Viale Morgagni 85, 50134, Florence, Italy aut NATIONALLICENCE 700 1- Mangoni M. Radiotherapy Unit, University of Florence, Viale Morgagni 85, 50134, Florence, Italy aut NATIONALLICENCE 700 1- Livi L. Radiotherapy Unit, IFCA, University of Florence, Florence, Italy aut NATIONALLICENCE 700 1- Agresti B. Radiotherapy Unit, University of Florence, Viale Morgagni 85, 50134, Florence, Italy aut NATIONALLICENCE 700 1- Franceschini D. Radiotherapy Unit, University of Florence, Viale Morgagni 85, 50134, Florence, Italy aut NATIONALLICENCE 700 1- Bonomo P. Radiotherapy Unit, IFCA, University of Florence, Florence, Italy aut NATIONALLICENCE 700 1- Scotti V. Radiotherapy Unit, University of Florence, Viale Morgagni 85, 50134, Florence, Italy aut NATIONALLICENCE 700 1- Detti B. Radiotherapy Unit, University of Florence, Viale Morgagni 85, 50134, Florence, Italy aut NATIONALLICENCE 700 1- Tonelli F. Department of Surgery, University of Florence, Viale Morgagni 85, 50134, Florence, Italy aut NATIONALLICENCE 700 1- Valeri A. Department of Surgery, University of Florence, Viale Morgagni 85, 50134, Florence, Italy aut NATIONALLICENCE 700 1- Messerini L. Department of Pathology, University of Florence, Viale Morgagni 85, 50134, Florence, Italy aut NATIONALLICENCE 700 1- Biti G. Radiotherapy Unit, University of Florence, Viale Morgagni 85, 50134, Florence, Italy aut NATIONALLICENCE 773 0- La radiologia medica Springer Milan 118/4(2013-06-01), 570-582 0033-8362 118:4<570 2013 118 11547 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer