naa a22 4500 510747949 CHVBK 20180411083053.0 cr unu---uuuuu 180411e20131201xx s 000 0 eng 10.1007/s11547-013-0926-y doi (NATIONALLICENCE)springer-10.1007/s11547-013-0926-y Evolution of the subsolid pulmonary nodule: a retrospective study in patients with different neoplastic diseases in a nonscreening clinical context [Elektronische Daten] [Domenico Attinà, Fabio Niro, Margherita Stellino, Federica Ciccarese, Giangaspare Mineo, Nicola Sverzellati, Maurizio Zompatori] L'evoluzione del nodulo polmonare subsolido: studio retrospettivo in pazienti con differenti patologie neoplastiche non sottoposti a screening Purpose: The aims of this study were to evaluate the high-resolution computed tomography (HRCT) features of subsolid pulmonary nodules (SSN) detected in cancer patients to differentiate between benign and malignant lesions, to assess their evolution during the follow-up, and to determine which neoplastic diseases are most frequently associated with the growth in size and/or density of SSN. Materials and methods: Ninety-seven patients with a total of 146 subsolid nodules [140 pure ground-glass opacities (pGGOs) and six mixed ground-glass opacities (mGGOs)] were retrospectively recruited. Two chest radiologists independently reviewed the HRCT features of the nodules (location, shape, size, density) and the patients' clinical characteristics (sex, age, smoking and cancer history). Mean duration of follow-up was more than 2 years. Results: During follow-up, 58% of SSN remained stable, 10% disappeared. An increase in size and/or density was seen in 32% of SSN, and in particular in partly solid (mGGOs), large (≥10 mm) and irregular nodules. The majority of small-size (<5 mm) rounded SSN remained stable. SSN growth was more frequent in patients with advanced age and a history of smoking, and occurred even after a long period of stability (39% of pGGOs "changed” over 3 years). The neoplastic diseases most frequently associated with SSN growth were cancers of lung (34%), breast (15%), colon (15%) and bladder (10%). Conclusions: The observation of a sample of cancer patients has shown that SSN may frequently grow in size and/or density in these patients, especially if associated powith cancers of lung, breast, colon and bladder. As the majority of SSN showed a very slow development time, a follow-up period longer than 3 years is warranted even in cancer patients. Springer-Verlag, 2013 Subsolid pulmonary nodule nationallicence Nodular groundglass opacity nationallicence HRCT nationallicence Follow-up nationallicence Cancer patient nationallicence Nodulo polmonare subsolido nationallicence Ground glass nationallicence HRCT nationallicence Follow-up nationallicence Paziente oncologico nationallicence Attinà Domenico Cardio-Thoracic Radiology Unit, Cardio-Thoracic-Vascular Department, University Hospital S. Orsola-Malpighi, Via Massarenti 9, 40128, Bologna, Italy aut Niro Fabio Cardio-Thoracic Radiology Unit, Cardio-Thoracic-Vascular Department, University Hospital S. Orsola-Malpighi, Via Massarenti 9, 40128, Bologna, Italy aut Stellino Margherita Cardio-Thoracic Radiology Unit, Cardio-Thoracic-Vascular Department, University Hospital S. Orsola-Malpighi, Via Massarenti 9, 40128, Bologna, Italy aut Ciccarese Federica Cardio-Thoracic Radiology Unit, Cardio-Thoracic-Vascular Department, University Hospital S. Orsola-Malpighi, Via Massarenti 9, 40128, Bologna, Italy aut Mineo Giangaspare Cardio-Thoracic Radiology Unit, Cardio-Thoracic-Vascular Department, University Hospital S. Orsola-Malpighi, Via Massarenti 9, 40128, Bologna, Italy aut Sverzellati Nicola Department of Clinical Sciences, Section of Radiological Sciences, University of Parma, Via Gramsci 14, 43100, Parma, Italy aut Zompatori Maurizio Cardio-Thoracic Radiology Unit, Cardio-Thoracic-Vascular Department, University Hospital S. Orsola-Malpighi, Via Massarenti 9, 40128, Bologna, Italy aut La radiologia medica Springer-Verlag 118/8(2013-12-01), 1269-1280 0033-8362 118:8<1269 2013 118 11547 https://doi.org/10.1007/s11547-013-0926-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11547-013-0926-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Attinà Domenico Cardio-Thoracic Radiology Unit, Cardio-Thoracic-Vascular Department, University Hospital S. Orsola-Malpighi, Via Massarenti 9, 40128, Bologna, Italy aut NATIONALLICENCE 700 1- Niro Fabio Cardio-Thoracic Radiology Unit, Cardio-Thoracic-Vascular Department, University Hospital S. Orsola-Malpighi, Via Massarenti 9, 40128, Bologna, Italy aut NATIONALLICENCE 700 1- Stellino Margherita Cardio-Thoracic Radiology Unit, Cardio-Thoracic-Vascular Department, University Hospital S. Orsola-Malpighi, Via Massarenti 9, 40128, Bologna, Italy aut NATIONALLICENCE 700 1- Ciccarese Federica Cardio-Thoracic Radiology Unit, Cardio-Thoracic-Vascular Department, University Hospital S. Orsola-Malpighi, Via Massarenti 9, 40128, Bologna, Italy aut NATIONALLICENCE 700 1- Mineo Giangaspare Cardio-Thoracic Radiology Unit, Cardio-Thoracic-Vascular Department, University Hospital S. Orsola-Malpighi, Via Massarenti 9, 40128, Bologna, Italy aut NATIONALLICENCE 700 1- Sverzellati Nicola Department of Clinical Sciences, Section of Radiological Sciences, University of Parma, Via Gramsci 14, 43100, Parma, Italy aut NATIONALLICENCE 700 1- Zompatori Maurizio Cardio-Thoracic Radiology Unit, Cardio-Thoracic-Vascular Department, University Hospital S. Orsola-Malpighi, Via Massarenti 9, 40128, Bologna, Italy aut NATIONALLICENCE 773 0- La radiologia medica Springer-Verlag 118/8(2013-12-01), 1269-1280 0033-8362 118:8<1269 2013 118 11547 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer