naa a22 4500 510747973 CHVBK 20180411083053.0 cr unu---uuuuu 180411e20131201xx s 000 0 eng 10.1007/s11547-013-0936-9 doi (NATIONALLICENCE)springer-10.1007/s11547-013-0936-9 Giant cell-rich osteosarcoma in long bones: clinical, radiological and pathological features [Elektronische Daten] [Cheng-Sheng Wang, Qi-Hua Yin, Jin-Sheng Liao, Jiang-Hua Lou, Xiao-Yi Ding, Yan-Bo Zhu] Osteosarcoma ricco in cellule giganti delle ossa lunghe: caratteristiche cliniche, radiologiche e patologiche Purpose: The purpose of this study was to review the clinical presentation, imaging, pathology and outcome of patients with giant cell-rich osteosarcoma (GCRO) of long bones. Materials and methods: Radiography (n=9), magnetic resonance imaging (MRI) (n=6), computed tomography (CT) (n=3) and clinical course of nine patients (five males and four females; mean age, 26 years) with pathologically confirmed GCRO were retrospectively reviewed. Specific imaging findings, including size, eccentricity, ossification, lysis, cystic change, expansile growth, periosteal reaction, cortical destruction, soft tissue extension and joint involvement were documented. Results: Presenting symptoms were pain in six patients and pain and palpable mass in three. An ill-defined margin surrounding a predominantly osteolytic lesion was detected at the proximal tibia (n=7) or femur (n=2) on imaging studies. Seven cases showed limited ossification. Three cases had tumours in the metaphysis and six in the metaepiphysis. The average maximum tumour dimension was 4.7 cm×5.2 cm×7.8 cm. Microscopically, tumours were composed of atypical cells with scanty osteoid formation and multinucleated giant cells. All patients received chemotherapy, and surgery was performed in eight patients. Three patients were dead and six were alive at the last follow-up. Conclusions: GCRO is a rarer variant that has very close resemblance to giant cell tumour. Patients usually present nonspecific symptoms of pain and palpable mass. It usually shows an osteolytic lesion with locally spared new bone formation in the metaphysis and/or metaepiphysis on imaging. Histologically, the atypical tumour cells with osteoid formation and multinucleated giant cells are the key factor in the diagnosis and differential diagnosis. Springer-Verlag, 2013 Bone neoplasms nationallicence Giant cell tumour of bone nationallicence Osteosarcoma nationallicence Tomography nationallicence X-ray nationallicence Computed tomography nationallicence Magnetic resonance imaging nationallicence Neoplasia ossea nationallicence Tumore osseo a cellule giganti nationallicence Osteosarcoma nationallicence Tomografia computerizzata nationallicence Risonanza magnetica nationallicence Wang Cheng-Sheng Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No.197, Ruijin 2nd Road, 200025, Shanghai, China aut Yin Qi-Hua Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No.197, Ruijin 2nd Road, 200025, Shanghai, China aut Liao Jin-Sheng Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No.197, Ruijin 2nd Road, 200025, Shanghai, China aut Lou Jiang-Hua Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No.197, Ruijin 2nd Road, 200025, Shanghai, China aut Ding Xiao-Yi Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No.197, Ruijin 2nd Road, 200025, Shanghai, China aut Zhu Yan-Bo Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China aut La radiologia medica Springer-Verlag 118/8(2013-12-01), 1324-1334 0033-8362 118:8<1324 2013 118 11547 https://doi.org/10.1007/s11547-013-0936-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11547-013-0936-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Cheng-Sheng Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No.197, Ruijin 2nd Road, 200025, Shanghai, China aut NATIONALLICENCE 700 1- Yin Qi-Hua Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No.197, Ruijin 2nd Road, 200025, Shanghai, China aut NATIONALLICENCE 700 1- Liao Jin-Sheng Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No.197, Ruijin 2nd Road, 200025, Shanghai, China aut NATIONALLICENCE 700 1- Lou Jiang-Hua Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No.197, Ruijin 2nd Road, 200025, Shanghai, China aut NATIONALLICENCE 700 1- Ding Xiao-Yi Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No.197, Ruijin 2nd Road, 200025, Shanghai, China aut NATIONALLICENCE 700 1- Zhu Yan-Bo Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China aut NATIONALLICENCE 773 0- La radiologia medica Springer-Verlag 118/8(2013-12-01), 1324-1334 0033-8362 118:8<1324 2013 118 11547 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer