naa a22 4500 510748090 CHVBK 20180411083054.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s11547-012-0882-x doi (NATIONALLICENCE)springer-10.1007/s11547-012-0882-x Parathyroid-gland ultrasonography in clinical and therapeutic evaluation of renal secondary hyperparathyroidism [Elektronische Daten] [C. Vulpio, M. Bossola, S. Magalini, P. Silvestri, G. Fadda, M. Ciliberti, M. D'Andrea, G. Maresca] Ecografia delle paratiroidi nella valutazione clinica e terapeutica dell'iperparatiroidismo secondario renale Purpose: This study evaluated the relationship between ultrasonographic (US) parameters of parathyroid glands (PTGs) in haemodialysis patients (HDP) and degree of secondary hyperparathyroidism (SHPT), therapeutic responsiveness and type of PTG hyperplasia (diffuse or nodular). Materials and methods: In 85 HDP, we evaluated the following US parameters of all and of the largest PTGs: number, maximum longitudinal diameter (MLD), structural (hypoechoic, heterogeneous, nodular) and vascular (nonhypovascular, intermediate, hypervascular) echo-pattern scores. Sixty-nine HDP underwent medical therapy (vitamin D, 39; vitamin D/cinacalcet, 30) and 16 underwent parathyroidectomy. The 69 HDP were classified as responders [median intact parathyroid hormone (iPTH) ≤300 pg/ml during follow-up) or nonresponders (iPTH >300 pg/ml). Results: Number, MLD and structural and vascular echo patterns of PTGs were significantly correlated with iPTH and calcium concentrations. In the 41 (59%) responders, number (0-1), MLD (<10 mm) and structural and vascular scores (1-2) of the largest PTG were significantly lower than in nonresponders. Receiver operating curve (ROC) curve analysis showed high sensitivity and specificity (90% and 73%, respectively) of the MLD (<10mm) of the largest PTG in the predicting therapeutic outcome. US and histological MLD are significantly correlated and predict the type of hyperplasia. Conclusions: US parameters of PTGs are correlated to the degree of SHPT and type of hyperplasia and predict responsiveness to medical therapy. Springer-Verlag Italia, 2012 Ultrasonography nationallicence Secondary hyperparathyroidism nationallicence Parathyroid glands nationallicence Vitamin D nationallicence Cinacalcet nationallicence Ecografia nationallicence Iperparatiroidismo secondario nationallicence Paratiroidi nationallicence Vitamina D nationallicence Cinacalcet nationallicence Vulpio C. Istituto Clinica Chirurgica, Università Cattolica del Sacro Cuore, Largo A. Gemelli 8, 00168, Roma, Italy aut Bossola M. Istituto Clinica Chirurgica, Università Cattolica del Sacro Cuore, Largo A. Gemelli 8, 00168, Roma, Italy aut Magalini S. Istituto Clinica Chirurgica, Università Cattolica del Sacro Cuore, Largo A. Gemelli 8, 00168, Roma, Italy aut Silvestri P. Istituto Clinica Chirurgica, Università Cattolica del Sacro Cuore, Largo A. Gemelli 8, 00168, Roma, Italy aut Fadda G. Istituto di Anatomia Patologica, Università Cattolica del Sacro Cuore, Largo A. Gemelli 8, 00168, Roma, Italy aut Ciliberti M. Istituto di Radiologia, Università Cattolica del Sacro Cuore, Largo A. Gemelli 8, 00168, Roma, Italy aut D'Andrea M. Istituto di Radiologia, Università Cattolica del Sacro Cuore, Largo A. Gemelli 8, 00168, Roma, Italy aut Maresca G. Istituto di Radiologia, Università Cattolica del Sacro Cuore, Largo A. Gemelli 8, 00168, Roma, Italy aut La radiologia medica Springer Milan 118/5(2013-08-01), 707-722 0033-8362 118:5<707 2013 118 11547 https://doi.org/10.1007/s11547-012-0882-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11547-012-0882-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vulpio C. Istituto Clinica Chirurgica, Università Cattolica del Sacro Cuore, Largo A. Gemelli 8, 00168, Roma, Italy aut NATIONALLICENCE 700 1- Bossola M. Istituto Clinica Chirurgica, Università Cattolica del Sacro Cuore, Largo A. Gemelli 8, 00168, Roma, Italy aut NATIONALLICENCE 700 1- Magalini S. Istituto Clinica Chirurgica, Università Cattolica del Sacro Cuore, Largo A. Gemelli 8, 00168, Roma, Italy aut NATIONALLICENCE 700 1- Silvestri P. Istituto Clinica Chirurgica, Università Cattolica del Sacro Cuore, Largo A. Gemelli 8, 00168, Roma, Italy aut NATIONALLICENCE 700 1- Fadda G. Istituto di Anatomia Patologica, Università Cattolica del Sacro Cuore, Largo A. Gemelli 8, 00168, Roma, Italy aut NATIONALLICENCE 700 1- Ciliberti M. Istituto di Radiologia, Università Cattolica del Sacro Cuore, Largo A. Gemelli 8, 00168, Roma, Italy aut NATIONALLICENCE 700 1- D'Andrea M. Istituto di Radiologia, Università Cattolica del Sacro Cuore, Largo A. Gemelli 8, 00168, Roma, Italy aut NATIONALLICENCE 700 1- Maresca G. Istituto di Radiologia, Università Cattolica del Sacro Cuore, Largo A. Gemelli 8, 00168, Roma, Italy aut NATIONALLICENCE 773 0- La radiologia medica Springer Milan 118/5(2013-08-01), 707-722 0033-8362 118:5<707 2013 118 11547 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer