naa a22 4500 510748120 CHVBK 20180411083054.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s11547-012-0880-0 doi (NATIONALLICENCE)springer-10.1007/s11547-012-0880-0 Role of whole-body 64-slice multidetector computed tomography in treatment planning for multiple myeloma [Elektronische Daten] [Ahmed Razek, Amany Ezzat, Emad Azmy, Nehal Tharwat] Il ruolo della tomografia computerizzata multidetettore a 64 strati total body nella pianificazione del trattamento del mieloma multiplo Purpose: The authors evaluated the role of whole-body 64-slice multidetector computed tomography (WB-MDCT) in treatment planning for multiple myeloma. Material and methods: This was a prospective study of 28 consecutive patients with multiple myeloma (19 men, nine women; age range, 51-73 years; mean age, 60 years) who underwent WB-MDCT and conventional radiography (CR) of the skeleton. The images were interpreted for the presence of bony lesions, medullary lesions, fractures and extraosseous lesions. We evaluated any changes in treatment planning as a result of WB-MDCT findings. Results: WB-MDCT was superior to CR for detecting bony lesions (p=0.001), especially of the spine (p=0.001) and thoracic cage (p=0.006). WB-MDCT upstaged 14 patients, with a significant difference in staging (p=0.002) between WB-MDCT and CR. Medullary involvement either focal (n=6) or diffuse (n=3) had a positive correlation with the overall score (r=0.790) and stage (r=0.618) of disease. Spine fractures were better detected at WB-MDCT (n=4) than at CR (n=2). Extraosseous soft tissue lesions (n=7) were detected only at WB-MDCT. Findings detected at the WB-MDCT led to changes in the patient's treatment plan in 39% of cases. Upstaging of seven patients (25%) altered the medical treatment plan, and four of 28 (14%) patients required additional radiotherapy (7%) and vertebroplasty (7%). Conclusions: We conclude that WB-MDCT has an impact on treatment planning and prognosis in patients with multiple myeloma, as it has high rate of detecting cortical and medullary bone lesions, spinal fracture and extraosseous lesions. This information may alter treatment planning in multiple myeloma due to disease upstaging and detection of spine fracture and extraosseous spinal lesions. Springer-Verlag Italia, 2012 Myeloma nationallicence Bone nationallicence Spine nationallicence CT nationallicence Whole-body nationallicence Radiography nationallicence Staging nationallicence Mieloma nationallicence Osso nationallicence Colonna vertebrale nationallicence TC nationallicence Total-body nationallicence Radiografia nationallicence Stadiazione nationallicence Razek Ahmed Department of Diagnostic Radiology, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt aut Ezzat Amany Department of Diagnostic Radiology, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt aut Azmy Emad Medical Oncology Unit, Oncology Center, Mansoura University, Mansoura, Egypt aut Tharwat Nehal Department of Diagnostic Radiology, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt aut La radiologia medica Springer Milan 118/5(2013-08-01), 799-805 0033-8362 118:5<799 2013 118 11547 https://doi.org/10.1007/s11547-012-0880-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11547-012-0880-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Razek Ahmed Department of Diagnostic Radiology, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt aut NATIONALLICENCE 700 1- Ezzat Amany Department of Diagnostic Radiology, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt aut NATIONALLICENCE 700 1- Azmy Emad Medical Oncology Unit, Oncology Center, Mansoura University, Mansoura, Egypt aut NATIONALLICENCE 700 1- Tharwat Nehal Department of Diagnostic Radiology, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt aut NATIONALLICENCE 773 0- La radiologia medica Springer Milan 118/5(2013-08-01), 799-805 0033-8362 118:5<799 2013 118 11547 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer