naa a22 4500 510748198 CHVBK 20180411083054.0 cr unu---uuuuu 180411e20130801xx s 000 0 ita 10.1007/s11547-012-0906-7 doi (NATIONALLICENCE)springer-10.1007/s11547-012-0906-7 Radiochemioterapia adiuvante nei pazienti anziani affetti da glioblastoma: esperienza di un singolo istituto e revisione della letteratura [Elektronische Daten] [A. Fiorentino, C. Chiumento, R. Caivano, M. Cozzolino, P. Pedicini, V. Fusco] Adjuvant radiochemotherapy in the elderly affected by glioblastoma: single-institution experience and literature review Purpose: Radiochemotherapy (RCT) is the standard adjuvant treatment for patients affected by glioblastoma (GBM). As there is no evidence in elderly patients with GBM, combined, single modality or best supportive care is used. The aim of this retrospective study was to evaluate acute toxicity and outcome of elderly patients with GBM treated with RCT with temozolomide (TMZ). Materials and methods: Patients >65 years with newly diagnosed GBM who underwent surgery or biopsy and RCT were evaluated. Recursive Partitioning Analysis (RPA) class and National Cancer Institute — Common Toxicity Criteria (NCI-CTC) version 3 were used to classify patients and evaluate acute toxicity, respectively. Results: From April 2005 to January 2011, 35 patients (18 women and 17 men) with GBM were treated at our institution. Only 31.43% of cases underwent complete resection. Median progression-free survival (PFS) was 8 months and median overall survival (OS) 13 months. At univariate and multivariate analysis, only RPA class correlated with OS (p=0.01, p=0.03, respectively). During RCT, toxicity was mild (thrombocytopaenia G3-4, 11.43%; neurological toxicity, G3-4, 8.57%). Conclusions: Our data suggest that RCT with TMZ seems to produce a better outcome with a mild toxicity profile in elderly patients affected by GBM. Springer-Verlag Italia, 2012 Glioblastoma nationallicence Radiotherapy nationallicence Elderly nationallicence Chemotherapy nationallicence Glioblastoma nationallicence Radioterapia nationallicence Pazienti anziani nationallicence Chemioterapia nationallicence Fiorentino A. Department of Radiation Oncology, I.R.C.C.S.-C.R.O.B., Via S. Pio 1, 85028, Rionero in Vulture (PZ), Italy aut Chiumento C. Department of Radiation Oncology, I.R.C.C.S.-C.R.O.B., Via S. Pio 1, 85028, Rionero in Vulture (PZ), Italy aut Caivano R. Department of Radiation Oncology, I.R.C.C.S.-C.R.O.B., Via S. Pio 1, 85028, Rionero in Vulture (PZ), Italy aut Cozzolino M. Department of Radiation Oncology, I.R.C.C.S.-C.R.O.B., Via S. Pio 1, 85028, Rionero in Vulture (PZ), Italy aut Pedicini P. Department of Radiation Oncology, I.R.C.C.S.-C.R.O.B., Via S. Pio 1, 85028, Rionero in Vulture (PZ), Italy aut Fusco V. Department of Radiation Oncology, I.R.C.C.S.-C.R.O.B., Via S. Pio 1, 85028, Rionero in Vulture (PZ), Italy aut La radiologia medica Springer Milan 118/5(2013-08-01), 870-881 0033-8362 118:5<870 2013 118 11547 https://doi.org/10.1007/s11547-012-0906-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11547-012-0906-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fiorentino A. Department of Radiation Oncology, I.R.C.C.S.-C.R.O.B., Via S. Pio 1, 85028, Rionero in Vulture (PZ), Italy aut NATIONALLICENCE 700 1- Chiumento C. Department of Radiation Oncology, I.R.C.C.S.-C.R.O.B., Via S. Pio 1, 85028, Rionero in Vulture (PZ), Italy aut NATIONALLICENCE 700 1- Caivano R. Department of Radiation Oncology, I.R.C.C.S.-C.R.O.B., Via S. Pio 1, 85028, Rionero in Vulture (PZ), Italy aut NATIONALLICENCE 700 1- Cozzolino M. Department of Radiation Oncology, I.R.C.C.S.-C.R.O.B., Via S. Pio 1, 85028, Rionero in Vulture (PZ), Italy aut NATIONALLICENCE 700 1- Pedicini P. Department of Radiation Oncology, I.R.C.C.S.-C.R.O.B., Via S. Pio 1, 85028, Rionero in Vulture (PZ), Italy aut NATIONALLICENCE 700 1- Fusco V. Department of Radiation Oncology, I.R.C.C.S.-C.R.O.B., Via S. Pio 1, 85028, Rionero in Vulture (PZ), Italy aut NATIONALLICENCE 773 0- La radiologia medica Springer Milan 118/5(2013-08-01), 870-881 0033-8362 118:5<870 2013 118 11547 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer