naa a22 4500 510748228 CHVBK 20180411083054.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s11547-012-0883-9 doi (NATIONALLICENCE)springer-10.1007/s11547-012-0883-9 Setup margins and geometric uncertainties in intensity-modulated radiation therapy in treating pituitary adenomas: the experience of Lyon Sud Hospital [Elektronische Daten] [B. De Bari, I. Shakir, T. Chekrine, L. Lestrade, V. Favrel] Margini di setup e incertezze geometriche nella radioterapia ad intensità modulata degli adenomi ipofisiari: l'esperienza dell'ospedale Lyon Sud Purpose: The authors retrospectively evaluated the setup uncertainties in Intensity-Modulated Radiation Therapy (IMRT) for pituitary adenomas and verified the margins used in daily practice (3 mm). Materials and methods: Craniocaudal (CC), anteroposterior (AP) and laterolateral (LL) displacements were measured during the first 3 days of treatment and then weekly by comparing two orthogonal images obtained by an electronic system of portal imaging with Digitally Reconstructed Radiographs (DRRs). Setup Margins (SM) were defined according to the International Commission on Radiation Units (ICRU)-62 formula, the Stroom equation and the van Herk equation. The systematic (Σ) and random (σ) errors of the population were calculated as standard deviation (SD) of the population mean and the mean of SDs for every patient, respectively. Results: Twenty patients were treated by IMRT for pituitary adenomas, and a total of 231 measurements were obtained. Σ and σ were 0.6 and 1.3 mm, 0.8 and 1 mm, 1.2 and 1.5 mm in the AP, LL and CC direction, respectively. Larger setup margin was 2.4, 2.7 and 4 mm in the AP, LL and CC direction, respectively (van Herk formula). Conclusions: IMRT is a highly sophisticated treatment technique that requires precise definition and optimisation of local setup errors and, finally, of the irradiated volumes. The role of image-guided RT in these kinds of treatments should be prospectively evaluated. Springer-Verlag Italia, 2012 Pituitary adenomas nationallicence Radiotherapy nationallicence IMRT nationallicence Setup margins nationallicence IGRT nationallicence Adenomi ipofisiari nationallicence Radioterapia nationallicence IMRT nationallicence Margini di setup nationallicence IGRT nationallicence De Bari B. Service de Radiothérapie Oncologi, Centre Hospitalier Lyon-Sud, Chemin du Grand-Revoye, EA 3738, 69495, Pierre Benite Cedex, France aut Shakir I. Service de Radiothérapie Oncologi, Centre Hospitalier Lyon-Sud, Chemin du Grand-Revoye, EA 3738, 69495, Pierre Benite Cedex, France aut Chekrine T. Service de Radiothérapie Oncologi, Centre Hospitalier Lyon-Sud, Chemin du Grand-Revoye, EA 3738, 69495, Pierre Benite Cedex, France aut Lestrade L. Service de Radiothérapie Oncologi, Centre Hospitalier Lyon-Sud, Chemin du Grand-Revoye, EA 3738, 69495, Pierre Benite Cedex, France aut Favrel V. Service de Radiothérapie Oncologi, Centre Hospitalier Lyon-Sud, Chemin du Grand-Revoye, EA 3738, 69495, Pierre Benite Cedex, France aut La radiologia medica Springer Milan 118/5(2013-08-01), 863-869 0033-8362 118:5<863 2013 118 11547 https://doi.org/10.1007/s11547-012-0883-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11547-012-0883-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- De Bari B. Service de Radiothérapie Oncologi, Centre Hospitalier Lyon-Sud, Chemin du Grand-Revoye, EA 3738, 69495, Pierre Benite Cedex, France aut NATIONALLICENCE 700 1- Shakir I. Service de Radiothérapie Oncologi, Centre Hospitalier Lyon-Sud, Chemin du Grand-Revoye, EA 3738, 69495, Pierre Benite Cedex, France aut NATIONALLICENCE 700 1- Chekrine T. Service de Radiothérapie Oncologi, Centre Hospitalier Lyon-Sud, Chemin du Grand-Revoye, EA 3738, 69495, Pierre Benite Cedex, France aut NATIONALLICENCE 700 1- Lestrade L. Service de Radiothérapie Oncologi, Centre Hospitalier Lyon-Sud, Chemin du Grand-Revoye, EA 3738, 69495, Pierre Benite Cedex, France aut NATIONALLICENCE 700 1- Favrel V. Service de Radiothérapie Oncologi, Centre Hospitalier Lyon-Sud, Chemin du Grand-Revoye, EA 3738, 69495, Pierre Benite Cedex, France aut NATIONALLICENCE 773 0- La radiologia medica Springer Milan 118/5(2013-08-01), 863-869 0033-8362 118:5<863 2013 118 11547 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer