naa a22 4500 510748244 CHVBK 20180411083055.0 cr unu---uuuuu 180411e20130301xx s 000 0 eng 10.1007/s11547-012-0830-x doi (NATIONALLICENCE)springer-10.1007/s11547-012-0830-x Contrast-enhanced ultrasound evaluation of peripheral microcirculation in diabetic patients: effects of cigarette smoking [Elektronische Daten] [M. Mancini, O. Di Donato, G. Saldalamacchia, R. Liuzzi, A. Rivellese, M. Salvatore] L'ecografia con mezzo di contrasto nello studio del microcircolo in pazienti diabetici: valutazione degli effetti del fumo di sigaretta Purpose: Cigarette smoking and diabetes mellitus predisposes to vascular disease. Our study aimed to evaluate the chronic effects of cigarette smoking on peripheral microcirculation assessed with contrast-enhanced ultrasound (CEUS) in diabetic patients. Materials and methods: The study population comprised ten smoker (7/3 M/W, age 42-76 years) and 16 nonsmoker (8/8 men/women, age 47-80 years) diabetic patients. The ankle-brachial index (ABI) was determined, and colour Doppler ultrasound (CDUS) of the lower legs was performed to determine the presence of peripheral arteriopathy disease (PAD). Microvascular blood flow in the gastrocnemius muscle was evaluated with CEUS. Results: No differences were observed in ABI and CDUS examination between smokers and nonsmokers. Smoking had a significant effect on microcirculatory function. Timeto-peak (TTP), arrival time in tissue (ATt) and artery/ tissue transit time (A/Ttt) were significantly prolonged in smokers (TTP 43.76±9.38 s vs. 34.12±6.8 s, p=0.011, ATt 28.9±7.5s vs. 22.4±6.4 s, p=0.017 and A/Ttt 6.81±4.52 s vs. 3.25±3.27 s, p=0.02), with no significant differences between patients with and without PAD. Conclusions: The long-term exposure to cigarette smoke affects microcirculatory function. Contrast imaging is a noninvasive technique that can document these effects. Springer-Verlag Italia, 2012 CEUS nationallicence Peripheral arterial disease nationallicence Diabetes nationallicence Smoking nationallicence Microcirculation nationallicence Ecografia con mezzo di contrasto nationallicence Vasculopatia periferica nationallicence Diabete nationallicence Fumo nationallicence Microcircolo nationallicence Mancini M. Institute of Biostructure and Bioimage, National Council of Research (CNR), Federico II University School of Medicine, Via Pansini 5, Edificio 10, 80131, Naples, Italy aut Di Donato O. Department of Biomorphological and Functional Science, Federico II University School of Medicine, Naples, Italy aut Saldalamacchia G. Department of Clinical and Experimental Medicine, Federico II University School of Medicine, Naples, Italy aut Liuzzi R. Institute of Biostructure and Bioimage, National Council of Research (CNR), Federico II University School of Medicine, Via Pansini 5, Edificio 10, 80131, Naples, Italy aut Rivellese A. Department of Clinical and Experimental Medicine, Federico II University School of Medicine, Naples, Italy aut Salvatore M. Department of Biomorphological and Functional Science, Federico II University School of Medicine, Naples, Italy aut La radiologia medica Springer Milan 118/2(2013-03-01), 206-214 0033-8362 118:2<206 2013 118 11547 https://doi.org/10.1007/s11547-012-0830-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11547-012-0830-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mancini M. Institute of Biostructure and Bioimage, National Council of Research (CNR), Federico II University School of Medicine, Via Pansini 5, Edificio 10, 80131, Naples, Italy aut NATIONALLICENCE 700 1- Di Donato O. Department of Biomorphological and Functional Science, Federico II University School of Medicine, Naples, Italy aut NATIONALLICENCE 700 1- Saldalamacchia G. Department of Clinical and Experimental Medicine, Federico II University School of Medicine, Naples, Italy aut NATIONALLICENCE 700 1- Liuzzi R. Institute of Biostructure and Bioimage, National Council of Research (CNR), Federico II University School of Medicine, Via Pansini 5, Edificio 10, 80131, Naples, Italy aut NATIONALLICENCE 700 1- Rivellese A. Department of Clinical and Experimental Medicine, Federico II University School of Medicine, Naples, Italy aut NATIONALLICENCE 700 1- Salvatore M. Department of Biomorphological and Functional Science, Federico II University School of Medicine, Naples, Italy aut NATIONALLICENCE 773 0- La radiologia medica Springer Milan 118/2(2013-03-01), 206-214 0033-8362 118:2<206 2013 118 11547 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer