naa a22 4500 510748333 CHVBK 20180411083055.0 cr unu---uuuuu 180411e20130301xx s 000 0 eng 10.1007/s11547-012-0833-7 doi (NATIONALLICENCE)springer-10.1007/s11547-012-0833-7 External-beam radiotherapy and/or HDR brachytherapy in postoperative endometrial cancer patients: clinical outcomes and toxicity rates [Elektronische Daten] [V. De Sanctis, L. Agolli, M. Valeriani, S. Narici, M. Osti, F. Patacchiola, B. Mossa, M. Moscarini, R. Maurizi Enrici] Brachiterapia HDR associata o meno alla radioterapia a fasci esterni in pazienti operate per carcinoma endometriale: risultati clinici e tossicità Purpose: The objectives of this study were to evaluate local disease control, overall survival (OS), disease-free survival (DFS) and local relapse-free survival (LRFS) in patients with endometrial cancer undergoing adjuvant vaginal brachytherapy (VBT)±external-beam radiotherapy (EBRT). Materials and methods: From September 2007 to February 2011, 40 patients with endometrial cancer were retrospectively analysed. Surgery consisted of total hysterectomy and bilateral salpingo-oophorectomy without node dissection (16 patients) or with bilateral pelvic node dissection (24 patients). The stage distribution was as follows: two IA, nine IB, 12 IC, five IIA, eight IIB, two IIIA and two IIIC. Thirty-four patients underwent EBRT and VBT. Six patients received VBT alone. Results: Median follow-up was 26 months. The 5-year OS and DFS were 96.4% and 86.9%, respectively. No local recurrence was observed. Four patients presented distant disease (three had lung metastases and one had hepatic node metastases). Acute EBRT-related toxicities were seen in 15 (38%) patients. We recorded late toxicities in 14 patients (35%). There was no evidence of grade 3-4 toxicity. Conclusions: Adjuvant EBRT and/or VBT in patients with endometrial cancer showed good outcomes in terms of local disease control, with an acceptable toxicity profile. Springer-Verlag Italia, 2012 Endometrial cancer nationallicence Radiotherapy nationallicence Brachytherapy nationallicence Cancro dell'endometrio nationallicence Radioterapia nationallicence Brachiterapia nationallicence De Sanctis V. Institute of Radiation Oncology, University "La Sapienza”, Ospedale S. Andrea, Via di Grottarossa 1035-1039, 00189, Rome, Italy aut Agolli L. Institute of Radiation Oncology, University "La Sapienza”, Ospedale S. Andrea, Via di Grottarossa 1035-1039, 00189, Rome, Italy aut Valeriani M. Institute of Radiation Oncology, University "La Sapienza”, Ospedale S. Andrea, Via di Grottarossa 1035-1039, 00189, Rome, Italy aut Narici S. Division of Medical Physics, University "La Sapienza”, Rome, Italy aut Osti M. Institute of Radiation Oncology, University "La Sapienza”, Ospedale S. Andrea, Via di Grottarossa 1035-1039, 00189, Rome, Italy aut Patacchiola F. Department of Health Science, University of L'Aquila, L'Aquila, Italy aut Mossa B. Department of Women Health and Medicine of the Territory, University "La Sapienza”, Rome, Italy aut Moscarini M. Department of Women Health and Medicine of the Territory, University "La Sapienza”, Rome, Italy aut Maurizi Enrici R. Institute of Radiation Oncology, University "La Sapienza”, Ospedale S. Andrea, Via di Grottarossa 1035-1039, 00189, Rome, Italy aut La radiologia medica Springer Milan 118/2(2013-03-01), 311-322 0033-8362 118:2<311 2013 118 11547 https://doi.org/10.1007/s11547-012-0833-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11547-012-0833-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- De Sanctis V. Institute of Radiation Oncology, University "La Sapienza”, Ospedale S. Andrea, Via di Grottarossa 1035-1039, 00189, Rome, Italy aut NATIONALLICENCE 700 1- Agolli L. Institute of Radiation Oncology, University "La Sapienza”, Ospedale S. Andrea, Via di Grottarossa 1035-1039, 00189, Rome, Italy aut NATIONALLICENCE 700 1- Valeriani M. Institute of Radiation Oncology, University "La Sapienza”, Ospedale S. Andrea, Via di Grottarossa 1035-1039, 00189, Rome, Italy aut NATIONALLICENCE 700 1- Narici S. Division of Medical Physics, University "La Sapienza”, Rome, Italy aut NATIONALLICENCE 700 1- Osti M. Institute of Radiation Oncology, University "La Sapienza”, Ospedale S. Andrea, Via di Grottarossa 1035-1039, 00189, Rome, Italy aut NATIONALLICENCE 700 1- Patacchiola F. Department of Health Science, University of L'Aquila, L'Aquila, Italy aut NATIONALLICENCE 700 1- Mossa B. Department of Women Health and Medicine of the Territory, University "La Sapienza”, Rome, Italy aut NATIONALLICENCE 700 1- Moscarini M. Department of Women Health and Medicine of the Territory, University "La Sapienza”, Rome, Italy aut NATIONALLICENCE 700 1- Maurizi Enrici R. Institute of Radiation Oncology, University "La Sapienza”, Ospedale S. Andrea, Via di Grottarossa 1035-1039, 00189, Rome, Italy aut NATIONALLICENCE 773 0- La radiologia medica Springer Milan 118/2(2013-03-01), 311-322 0033-8362 118:2<311 2013 118 11547 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer