naa a22 4500 510748368 CHVBK 20180411083055.0 cr unu---uuuuu 180411e20130301xx s 000 0 eng 10.1007/s11547-012-0841-7 doi (NATIONALLICENCE)springer-10.1007/s11547-012-0841-7 Assessment of activity of Crohn's disease of the ileum and large bowel: proposal for a new multiparameter MR enterography score [Elektronische Daten] [L. Macarini, L. Stoppino, A. Centola, S. Muscarella, F. Fortunato, F. Coppolino, N. Della Valle, V. Ierardi, P. Milillo, R. Vinci] Valutazione dell'attività di malattia del morbo di Crohn dell'ileo e dell'intestino crasso: proposta di un nuovo score E-RM multiparametrico Purpose: We evaluated the diagnostic accuracy of magnetic resonance enterography (MR-E) in assessing Crohn's disease (CD) activity by differentiating acute, chronic and remission stages of disease through a quantitative MR-E assessment. Materials and methods: One hundred patients with a histological diagnosis of CD were studied with MR-E. Intestinal distension was obtained by oral administration of approximately 2 L of a polyethylene glycol solution (PEG). In all cases, the ileum and large bowel were imaged with morphological sequences (heavily T2-weighted single-shot, dual fast-field echo, balanced fast-field echo) and a postcontrast dynamic sequence (T1-weighted high-resolution isotropic volume excitation). Disease activity was assessed according to a multiparameter score (0-8) based on lesion morphology, signal intensity and contrast enhancement. MR-E findings were compared with clinical-laboratory data and disease activity indices [Crohn's Disease Activity Index (CDAI); Inflammatory Bowel Disease Questionnaire (IBDQ)]. Multiple regression analysis was performed by correlating MR-E score, CDAI and IBDQ. Frequencies were then compared using the χ 2 test. Results: MR-E identified inactive disease in 9% of cases, chronic disease in 57% and active disease in the remaining 34%. The most frequently involved bowel segment was the terminal ileum (52%). A statistically significant correlation was found between MR-E score and CDAI (R=0.86; p<0.001) and between MR-E score and IBDQ (R=−0.83; p<0.001). The most suggestive parameter for disease activity was layered bowel-wall enhancement, a finding predominantly present in patients with increased CDAI (≥150) and/or local complications (χ 2=7.13; p<0.01). Conclusions: MR-E is a noninvasive and diagnostic imaging modality for CD study and follow-up. The MR-E score proposed in this study proved to be useful in assessing disease severity and monitoring response to treatment. Springer-Verlag Italia, 2012 Crohn's disease nationallicence MR enterography nationallicence Disease activity nationallicence MR enterography score nationallicence Morbo di Crohn nationallicence Enterografia-RM nationallicence Attività di malattia nationallicence Score E-RM nationallicence Macarini L. Department of Diagnostic Imaging, University of Foggia, Viale Luigi Pinto 1, 71100, Foggia, Italy aut Stoppino L. Department of Diagnostic Imaging, University of Foggia, Viale Luigi Pinto 1, 71100, Foggia, Italy aut Centola A. Department of Diagnostic Imaging, University of Foggia, Viale Luigi Pinto 1, 71100, Foggia, Italy aut Muscarella S. Department of Diagnostic Imaging, University of Foggia, Viale Luigi Pinto 1, 71100, Foggia, Italy aut Fortunato F. Department of Medical Science — Section of Hygiene, University of Foggia, Viale Luigi Pinto 1, 71100, Foggia, Italy aut Coppolino F. Department of Diagnostic Imaging, University of Palermo, Via del Vespro 127, 91027, Palermo, Italy aut Della Valle N. Department of Gastroenterology, University of Foggia, Viale Luigi Pinto 1, 71100, Foggia, Italy aut Ierardi V. Department of Gastroenterology, University of Foggia, Viale Luigi Pinto 1, 71100, Foggia, Italy aut Milillo P. Department of Diagnostic Imaging, University of Foggia, Viale Luigi Pinto 1, 71100, Foggia, Italy aut Vinci R. Department of Diagnostic Imaging, University of Foggia, Viale Luigi Pinto 1, 71100, Foggia, Italy aut La radiologia medica Springer Milan 118/2(2013-03-01), 181-195 0033-8362 118:2<181 2013 118 11547 https://doi.org/10.1007/s11547-012-0841-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11547-012-0841-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Macarini L. Department of Diagnostic Imaging, University of Foggia, Viale Luigi Pinto 1, 71100, Foggia, Italy aut NATIONALLICENCE 700 1- Stoppino L. Department of Diagnostic Imaging, University of Foggia, Viale Luigi Pinto 1, 71100, Foggia, Italy aut NATIONALLICENCE 700 1- Centola A. Department of Diagnostic Imaging, University of Foggia, Viale Luigi Pinto 1, 71100, Foggia, Italy aut NATIONALLICENCE 700 1- Muscarella S. Department of Diagnostic Imaging, University of Foggia, Viale Luigi Pinto 1, 71100, Foggia, Italy aut NATIONALLICENCE 700 1- Fortunato F. Department of Medical Science — Section of Hygiene, University of Foggia, Viale Luigi Pinto 1, 71100, Foggia, Italy aut NATIONALLICENCE 700 1- Coppolino F. Department of Diagnostic Imaging, University of Palermo, Via del Vespro 127, 91027, Palermo, Italy aut NATIONALLICENCE 700 1- Della Valle N. Department of Gastroenterology, University of Foggia, Viale Luigi Pinto 1, 71100, Foggia, Italy aut NATIONALLICENCE 700 1- Ierardi V. Department of Gastroenterology, University of Foggia, Viale Luigi Pinto 1, 71100, Foggia, Italy aut NATIONALLICENCE 700 1- Milillo P. Department of Diagnostic Imaging, University of Foggia, Viale Luigi Pinto 1, 71100, Foggia, Italy aut NATIONALLICENCE 700 1- Vinci R. Department of Diagnostic Imaging, University of Foggia, Viale Luigi Pinto 1, 71100, Foggia, Italy aut NATIONALLICENCE 773 0- La radiologia medica Springer Milan 118/2(2013-03-01), 181-195 0033-8362 118:2<181 2013 118 11547 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer