naa a22 4500 510748384 CHVBK 20180411083055.0 cr unu---uuuuu 180411e20130301xx s 000 0 eng 10.1007/s11547-012-0864-0 doi (NATIONALLICENCE)springer-10.1007/s11547-012-0864-0 Contrast-enhanced MR imaging of the breast: association between asymmetric increased breast vascularity and ipsilateral cancer in a consecutive series of 197 patients [Elektronische Daten] [N. Verardi, G. Di Leo, L. Carbonaro, M. Fedeli, F. Sardanelli] RM mammaria con mezzo di contrasto: associazione tra incremento asimmetrico della vascolarizzazione e tumore ipsilaterale in una serie consecutiva di 197 pazienti Purpose: This study was done to estimate the diagnostic performance of an asymmetric increase in breast vascularity (AIBV) for ipsilateral cancer. Materials and methods: A total of 197 patients without previous breast interventions underwent bilateral contrastenhanced (gadoterate meglumine, 0.1 mmol/kg) magnetic resonance (MR) imaging. Vessels >-2 mm in diameter and ≥3 cm in length were counted on maximum intensity projections: a difference ≥2 in number between the two breasts was considered AIBV. Pathology or ≥1 year follow-up served as a reference standard. The difference in sensitivity of AIBV between invasive and ductal carcinoma in situ (DCIS) as well as the association between AIBV and the diameter of invasive lesions or the histological grade were evaluated using χ2 test. Results: Pathology revealed 82 malignancies and 20 benign lesions: 70 invasive carcinomas (57 ductal, nine lobular, three mucinous, one papillary) and 12 DCIS: 10 fibroadenomas, two papillomas, two atypical ductal hyperplasias and six other benign lesions. The remaining 95 patients were negative at follow-up. Sensitivity of AIBV was 74% (61/82), specificity 94% (108/115), accuracy 86% (169/197), positive predictive value 90% (61/68) and negative predictive value 84% (108/129). Sensitivity for invasive cancers (80%; 56/70) was significantly higher than that for DCIS (42%; 5/12) (p<0.001). For invasive cancers, sensitivity was 40% (2/5) for lesions ≤9 mm in diameter, 69% (9/13) for those 10-14 mm, 79% (15/19) for those 15-19 mm and 91% (30/33) for those ≥20 mm (p<0.001). The G3 lesion rate was 49% (27/55) among true positives and only 7% (1/14) among false negatives (p=0.009). Conclusions: An association between AIBV and ipsilateral cancer exists, particularly for invasive cancers ≥20 mm or with high pathologic grade. Springer-Verlag Italia, 2012 Breast cancer nationallicence Magnetic resonance imaging nationallicence Breast vascular map asymmetry nationallicence Diagnostic performance nationallicence Tumore mammario nationallicence Risonanza magnetica nationallicence Vascolarizzazione mammaria, asimmetria nationallicence Performance diagnostica nationallicence Verardi N. Unità di Radiologia, IRCCS Policlinico San Donato, Piazza E. Malan 2, 20097, San Donato Milanese, Italy aut Di Leo G. Unità di Radiologia, IRCCS Policlinico San Donato, Piazza E. Malan 2, 20097, San Donato Milanese, Italy aut Carbonaro L. Unità di Radiologia, IRCCS Policlinico San Donato, Piazza E. Malan 2, 20097, San Donato Milanese, Italy aut Fedeli M. Scuola di Specializzazione in Radiodiagnostica, Università degli Studi di Milano, Via Festa del Perdono 7, 20122, Milan, Italy aut Sardanelli F. Unità di Radiologia, IRCCS Policlinico San Donato, Piazza E. Malan 2, 20097, San Donato Milanese, Italy aut La radiologia medica Springer Milan 118/2(2013-03-01), 239-250 0033-8362 118:2<239 2013 118 11547 https://doi.org/10.1007/s11547-012-0864-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11547-012-0864-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Verardi N. Unità di Radiologia, IRCCS Policlinico San Donato, Piazza E. Malan 2, 20097, San Donato Milanese, Italy aut NATIONALLICENCE 700 1- Di Leo G. Unità di Radiologia, IRCCS Policlinico San Donato, Piazza E. Malan 2, 20097, San Donato Milanese, Italy aut NATIONALLICENCE 700 1- Carbonaro L. Unità di Radiologia, IRCCS Policlinico San Donato, Piazza E. Malan 2, 20097, San Donato Milanese, Italy aut NATIONALLICENCE 700 1- Fedeli M. Scuola di Specializzazione in Radiodiagnostica, Università degli Studi di Milano, Via Festa del Perdono 7, 20122, Milan, Italy aut NATIONALLICENCE 700 1- Sardanelli F. Unità di Radiologia, IRCCS Policlinico San Donato, Piazza E. Malan 2, 20097, San Donato Milanese, Italy aut NATIONALLICENCE 773 0- La radiologia medica Springer Milan 118/2(2013-03-01), 239-250 0033-8362 118:2<239 2013 118 11547 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer