naa a22 4500 510750982 CHVBK 20180411083104.0 cr unu---uuuuu 180411e20131001xx s 000 0 eng 10.1007/s11270-013-1728-5 doi (NATIONALLICENCE)springer-10.1007/s11270-013-1728-5 The Effects of Bisphenol-A on the Immune System of Wild Yellow Perch, Perca flavescens [Elektronische Daten] [James Rogers, Reehan Mirza] Bisphenol-A (BPA) is an environmental contaminant used in the manufacturing of polycarbonate plastics and epoxy resins, which has been discovered in freshwater systems worldwide as a result of effluent from manufacturing. This bioactive molecule is an estrogen mimic and has become a concern for exposure, especially during development, resulting in its removal from baby bottles and other consumer products. BPA is an endocrine disruptor in a variety of species and has been classified as a toxic substance in multiple countries. In this study, we examined the effect of BPA exposure on leukocyte counts in wild yellow perch, Perca flavescens. Yellow perch were exposed to either 2, 4, and 8ppb BPA; Saprolegnia; or a blank control for a period of 7days. Leukocyte blood counts were significantly higher in Saprolegnia, 4ppb BPA, and 8ppb BPA treatments compared to control. To test compound effects of BPA and Saprolegnia on leukocyte counts over a 7-day period, perch were exposed to either 4ppb BPA, 4ppb BPA + Saprolegnia, or control. Leukocyte counts were significantly higher in the 4ppb BPA treatment relative to control. The 4ppb BPA + Saprolegnia treatment was numerically elevated from the control, exhibiting a 153% increase relative to control. BPA represents a contaminant with immunomodulatory properties that remain to be determined. Springer Science+Business Media Dordrecht, 2013 Bisphenol-A nationallicence Leukocyte nationallicence Immune system nationallicence Yellow perch nationallicence Saprolegnia nationallicence Endocrine disruptor nationallicence Rogers James Department of Biology and Chemistry, Nipissing University, 100 College Dr., P1B 8L7, North Bay, ON, Canada aut Mirza Reehan Department of Biology and Chemistry, Nipissing University, 100 College Dr., P1B 8L7, North Bay, ON, Canada aut Water, Air, & Soil Pollution Springer Netherlands 224/10(2013-10-01), 1-6 0049-6979 224:10<1 2013 224 11270 https://doi.org/10.1007/s11270-013-1728-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11270-013-1728-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rogers James Department of Biology and Chemistry, Nipissing University, 100 College Dr., P1B 8L7, North Bay, ON, Canada aut NATIONALLICENCE 700 1- Mirza Reehan Department of Biology and Chemistry, Nipissing University, 100 College Dr., P1B 8L7, North Bay, ON, Canada aut NATIONALLICENCE 773 0- Water, Air, & Soil Pollution Springer Netherlands 224/10(2013-10-01), 1-6 0049-6979 224:10<1 2013 224 11270 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer