naa a22 4500 510751741 CHVBK 20180411083107.0 cr unu---uuuuu 180411e20130501xx s 000 0 eng 10.1007/s11270-013-1579-0 doi (NATIONALLICENCE)springer-10.1007/s11270-013-1579-0 Endocrine Disruption in the European Eel, Anguilla anguilla , Exposed to an Environmental Cocaine Concentration [Elektronische Daten] [Flaminia Gay, Massimo Maddaloni, Salvatore Valiante, Vincenza Laforgia, Anna Capaldo] The aim of the present study was to verify if cocaine, at environmental concentrations, influences the endocrine system of the European eel. Silver eels (a stage of the eel life cycle preparing the fish for the oceanic reproductive migration) were exposed to a nominal cocaine concentration of 20ng/l during 30days; at the same time, control, carrier, and postexposure recovery groups were made. The effects of cocaine were observed in (1) brain dopamine content, (2) plasma catecholamine levels (dopamine, norepinephrine, and epinephrine), (3) pituitary-adrenal axis activity [plasma adrenocorticotropic hormone (ACTH), corticosterone, cortisol, and aldosterone levels], and (4) pituitary-thyroid axis activity [plasma thyroid-stimulating hormone (TSH), triiodothyronine, and thyroxine levels]. In the treated group, brain dopamine, plasma catecholamines, cortisol, and TSH levels were higher, whereas ACTH, corticosterone, and triiodothyronine levels were lower than controls. In the postexposure recovery group, brain dopamine, plasma dopamine and epinephrine, and thyroxine levels further increased, whereas plasma norepinephrine, cortisol, and corticosterone levels were similar to treated values. Finally, ACTH and TSH were similar, whereas triiodothyronine levels were lower than controls. Aldosterone levels were unaffected by cocaine exposure. The results of the present study show that cocaine, at environmental concentrations, behaves like an endocrine disruptor changing brain dopamine and plasma catecholamine levels and the activity of pituitary-adrenal/thyroid axes. Since the endocrine system plays a key role in the metabolic and reproductive processes of the eel, our results suggest that environmental cocaine could be considered another cause for the decline in the European eel. Springer Science+Business Media Dordrecht, 2013 Anguilla anguilla nationallicence Cocaine and eel catecholamines nationallicence Cocaine and eel corticosteroids nationallicence Cocaine and eel thyroid hormones nationallicence Eel endocrine disruption nationallicence Gay Flaminia Department of Biology, University Federico II, Via Mezzocannone 8, 80134, Naples, Italy aut Maddaloni Massimo Department of Biology, University Federico II, Via Mezzocannone 8, 80134, Naples, Italy aut Valiante Salvatore Department of Biology, University Federico II, Via Mezzocannone 8, 80134, Naples, Italy aut Laforgia Vincenza Department of Biology, University Federico II, Via Mezzocannone 8, 80134, Naples, Italy aut Capaldo Anna Department of Biology, University Federico II, Via Mezzocannone 8, 80134, Naples, Italy aut Water, Air, & Soil Pollution Springer Netherlands 224/5(2013-05-01), 1-11 0049-6979 224:5<1 2013 224 11270 https://doi.org/10.1007/s11270-013-1579-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11270-013-1579-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gay Flaminia Department of Biology, University Federico II, Via Mezzocannone 8, 80134, Naples, Italy aut NATIONALLICENCE 700 1- Maddaloni Massimo Department of Biology, University Federico II, Via Mezzocannone 8, 80134, Naples, Italy aut NATIONALLICENCE 700 1- Valiante Salvatore Department of Biology, University Federico II, Via Mezzocannone 8, 80134, Naples, Italy aut NATIONALLICENCE 700 1- Laforgia Vincenza Department of Biology, University Federico II, Via Mezzocannone 8, 80134, Naples, Italy aut NATIONALLICENCE 700 1- Capaldo Anna Department of Biology, University Federico II, Via Mezzocannone 8, 80134, Naples, Italy aut NATIONALLICENCE 773 0- Water, Air, & Soil Pollution Springer Netherlands 224/5(2013-05-01), 1-11 0049-6979 224:5<1 2013 224 11270 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer