naa a22 4500 510759130 CHVBK 20180411083132.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s13225-013-0265-2 doi (NATIONALLICENCE)springer-10.1007/s13225-013-0265-2 Bioactive metabolites from macrofungi: ethnopharmacology, biological activities and chemistry [Elektronische Daten] [Dilani De Silva, Sylvie Rapior, Enge Sudarman, Marc Stadler, Jianchu Xu, S. Aisyah Alias, Kevin Hyde] Exploration of natural sources for novel bioactive compounds has been an emerging field of medicine over the past decades, providing drugs or lead compounds of considerable therapeutic potential. This research has provided exciting evidence on the isolation of microbe-derived metabolites having prospective biological activities. Mushrooms have been valued as traditional sources of natural bioactive compounds for many centuries and have been targeted as promising therapeutic agents. Many novel biologically active compounds have been reported as a result of research on medicinal mushrooms. In this review, we compile the information on bioactive structure-elucidated metabolites from macrofungi discovered over the last decade and highlight their unique chemical diversity and potential benefits to novel drug discovery. The main emphasis is on their anti-Alzheimer, anti-diabetic, anti-malarial, anti-microbial, anti-oxidant, anti-tumor, anti-viral and hypocholesterolemic activities which are important medicinal targets in terms of drug discovery today. Moreover, the reader's attention is brought to focus on mushroom products and food supplements available in the market with claimed biological activities and potential human health benefits. Mushroom Research Foundation, 2013 Medicinal mushrooms nationallicence Anti-oxidant nationallicence Anti-tumor nationallicence Anti-HIV nationallicence Anti-microbial nationallicence Anti-viral nationallicence Hypocholesterolemic nationallicence Anti-diabetic nationallicence Anti-Alzheimer nationallicence Anti-malarial nationallicence Food supplements nationallicence De Silva Dilani Key Laboratory for Plant Biodiversity and Biogeography of East Asia (KLPB), Kunming Institute of Botany, Chinese Academy of Sciences, 650201, Kunming, Yunnan, China aut Rapior Sylvie Laboratory of Botany, Phytochemistry and Mycology Faculty of Pharmacy, University Montpellier 1, UMR 5175 CEFE, 15, avenue Charles Flahault, BP 14491, 34093, Montpellier Cedex 5, France aut Sudarman Enge Department of Microbial Drugs, Helmhotz Centre for Infection Research, Braunschweig, Germany aut Stadler Marc Department of Microbial Drugs, Helmhotz Centre for Infection Research, Braunschweig, Germany aut Xu Jianchu Key Laboratory for Plant Biodiversity and Biogeography of East Asia (KLPB), Kunming Institute of Botany, Chinese Academy of Sciences, 650201, Kunming, Yunnan, China aut Aisyah Alias S. Institute of Ocean and Earth Sciences, University of Malaya, 50603, Kuala Lumpur, Malaysia aut Hyde Kevin Key Laboratory for Plant Biodiversity and Biogeography of East Asia (KLPB), Kunming Institute of Botany, Chinese Academy of Sciences, 650201, Kunming, Yunnan, China aut Fungal Diversity Springer Netherlands 62/1(2013-09-01), 1-40 1560-2745 62:1<1 2013 62 13225 https://doi.org/10.1007/s13225-013-0265-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s13225-013-0265-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- De Silva Dilani Key Laboratory for Plant Biodiversity and Biogeography of East Asia (KLPB), Kunming Institute of Botany, Chinese Academy of Sciences, 650201, Kunming, Yunnan, China aut NATIONALLICENCE 700 1- Rapior Sylvie Laboratory of Botany, Phytochemistry and Mycology Faculty of Pharmacy, University Montpellier 1, UMR 5175 CEFE, 15, avenue Charles Flahault, BP 14491, 34093, Montpellier Cedex 5, France aut NATIONALLICENCE 700 1- Sudarman Enge Department of Microbial Drugs, Helmhotz Centre for Infection Research, Braunschweig, Germany aut NATIONALLICENCE 700 1- Stadler Marc Department of Microbial Drugs, Helmhotz Centre for Infection Research, Braunschweig, Germany aut NATIONALLICENCE 700 1- Xu Jianchu Key Laboratory for Plant Biodiversity and Biogeography of East Asia (KLPB), Kunming Institute of Botany, Chinese Academy of Sciences, 650201, Kunming, Yunnan, China aut NATIONALLICENCE 700 1- Aisyah Alias S. Institute of Ocean and Earth Sciences, University of Malaya, 50603, Kuala Lumpur, Malaysia aut NATIONALLICENCE 700 1- Hyde Kevin Key Laboratory for Plant Biodiversity and Biogeography of East Asia (KLPB), Kunming Institute of Botany, Chinese Academy of Sciences, 650201, Kunming, Yunnan, China aut NATIONALLICENCE 773 0- Fungal Diversity Springer Netherlands 62/1(2013-09-01), 1-40 1560-2745 62:1<1 2013 62 13225 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer