naa a22 4500 51076312X CHVBK 20180411083146.0 cr unu---uuuuu 180411e20130101xx s 000 0 eng 10.1007/s12094-012-0895-y doi (NATIONALLICENCE)springer-10.1007/s12094-012-0895-y Retreatment with radiotherapy for symptomatic bone, brain or visceral metastases [Elektronische Daten] [R. Hernanz, A. Montero, E. Fernandez-Lizarbe, A. Polo, A. Ramos] Background: The need for reirradiation in the metastatic disease appears when other modalities of treatment lose their efficacy. The aim of reirradiation in the metastatic disease is mainly palliative to control a particular symptom. However, this theoretical benefit must be confronted against the risk of an undesirable toxicity. Materials and Methods: Experience with reirradiation for symptomatic bone, brain or visceral metastases are reviewed. Twenty-two patients were found to have a second palliative radiotherapy on the same location. Locatión of metastases were visceral in 5 (23 %) patients, brain in 4 (18 %) patients, spine in 1 (4.5 %) patient and bone metastasis other than spine in 12 (54.5 %) patients. Median dose delivered in the first treatment was 30Gy (range 20-30Gy) and 20Gy for the second treatment (range 6-32.4Gy). Results: A good symptomatic response after first irradiation (complete response or disappearance of >50% of symptoms) was reached in 21 (95.5%) of the 22 patients analyzed. After second irradiation, 82% (18 patients) achieved a good response, 3 (14%) patients had a moderate response (relief of symptoms <50%) whereas no response was observed in 1 (4%) patient. Acute toxicity was limited to grade 1-2 proctitis in 2 and 3 patients after the first and second irradiation, respectively. No cases of late toxicity after the first or second irradiation were recorded. Conclusion: A second treatment with palliative radiotherapy is feasible and well tolerated and offers the possibility of symptomatic relief in a high percentage of patients with symptomatic metastases. Federación de Sociedades Españolas de Oncología (FESEO), 2012 Symptomatic metastases nationallicence Palliative reirradiation nationallicence Response rates nationallicence Toxicity profile nationallicence Hernanz R. Department of Radiation Oncology, University Hospital Ramón y Cajal, Cta. Colmenar Viejo, km 9.100, 28034, Madrid, Spain aut Montero A. Department of Radiation Oncology, University Hospital Ramón y Cajal, Cta. Colmenar Viejo, km 9.100, 28034, Madrid, Spain aut Fernandez-Lizarbe E. Department of Radiation Oncology, University Hospital Ramón y Cajal, Cta. Colmenar Viejo, km 9.100, 28034, Madrid, Spain aut Polo A. Department of Radiation Oncology, University Hospital Ramón y Cajal, Cta. Colmenar Viejo, km 9.100, 28034, Madrid, Spain aut Ramos A. Department of Radiation Oncology, University Hospital Ramón y Cajal, Cta. Colmenar Viejo, km 9.100, 28034, Madrid, Spain aut Clinical and Translational Oncology Springer Milan 15/1(2013-01-01), 72-78 1699-048X 15:1<72 2013 15 12094 https://doi.org/10.1007/s12094-012-0895-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-012-0895-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hernanz R. Department of Radiation Oncology, University Hospital Ramón y Cajal, Cta. Colmenar Viejo, km 9.100, 28034, Madrid, Spain aut NATIONALLICENCE 700 1- Montero A. Department of Radiation Oncology, University Hospital Ramón y Cajal, Cta. Colmenar Viejo, km 9.100, 28034, Madrid, Spain aut NATIONALLICENCE 700 1- Fernandez-Lizarbe E. Department of Radiation Oncology, University Hospital Ramón y Cajal, Cta. Colmenar Viejo, km 9.100, 28034, Madrid, Spain aut NATIONALLICENCE 700 1- Polo A. Department of Radiation Oncology, University Hospital Ramón y Cajal, Cta. Colmenar Viejo, km 9.100, 28034, Madrid, Spain aut NATIONALLICENCE 700 1- Ramos A. Department of Radiation Oncology, University Hospital Ramón y Cajal, Cta. Colmenar Viejo, km 9.100, 28034, Madrid, Spain aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/1(2013-01-01), 72-78 1699-048X 15:1<72 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer