naa a22 4500 510763235 CHVBK 20180411083147.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s12094-012-0982-0 doi (NATIONALLICENCE)springer-10.1007/s12094-012-0982-0 Nanoemulsions and nanoparticles for non-melanoma skin cancer: effects of lipid materials [Elektronische Daten] [P. Severino, J. Fangueiro, S. Ferreira, R. Basso, M. Chaud, M. Santana, A. Rosmaninho, E. Souto] Basal cell carcinomas and squamous cell carcinomas are non-melanoma skin cancers reported to be among the most common malignancies, being responsible for high human morbidity. Conventional chemotherapy applied to these conditions shows non-specific targeting, thus severe adverse side effects are also commonly reported. New therapeutic strategies based on nanoparticulates technology have emerged as alternatives for site specific chemotherapy. Among the different types of nanoparticulates, lipid nanoemulsions and nanoparticles have several advantages for topical delivery of poorly soluble chemotherapeutics. These particles show sustained drug release and protection of loaded drugs from chemical degradation. This technology is promising to enhance the intracellular concentration of drugs and consequently reduce the cytotoxicity of skin chemotherapy. Federación de Sociedades Españolas de Oncología (FESEO), 2012 Basal cell carcinomas (BCC) nationallicence Squamous cell carcinomas (SCC) nationallicence Lipid nanoemulsions (NEs) and nanoparticles (NPs) nationallicence Nanocarriers nationallicence Non-melanoma skin cancer nationallicence Severino P. Department of Biotechnological Processes, School of Engineering Chemical, University of Campinas-Unicamp, 13083-970, Campinas, Brazil aut Fangueiro J. Faculty of Health Sciences, Fernando Pessoa University, Rua Carlos da Maia, 296, Office S.1, 4200-150, Porto, Portugal aut Ferreira S. Faculty of Health Sciences, Fernando Pessoa University, Rua Carlos da Maia, 296, Office S.1, 4200-150, Porto, Portugal aut Basso R. Department of Plastic Surgery, School of Medicine, University of Campinas-Unicamp, 13083-970, Campinas, Brazil aut Chaud M. Laboratory for Development and Evaluation of Bioactive Substance, Sorocaba University (UNISO), 18023-000, Sorocaba, Brazil aut Santana M. Department of Biotechnological Processes, School of Engineering Chemical, University of Campinas-Unicamp, 13083-970, Campinas, Brazil aut Rosmaninho A. Department of Dermatology, Hospital Santo Antonio, CHP-EPE, Porto, Portugal aut Souto E. Faculty of Health Sciences, Fernando Pessoa University, Rua Carlos da Maia, 296, Office S.1, 4200-150, Porto, Portugal aut Clinical and Translational Oncology Springer Milan 15/6(2013-06-01), 417-424 1699-048X 15:6<417 2013 15 12094 https://doi.org/10.1007/s12094-012-0982-0 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-012-0982-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Severino P. Department of Biotechnological Processes, School of Engineering Chemical, University of Campinas-Unicamp, 13083-970, Campinas, Brazil aut NATIONALLICENCE 700 1- Fangueiro J. Faculty of Health Sciences, Fernando Pessoa University, Rua Carlos da Maia, 296, Office S.1, 4200-150, Porto, Portugal aut NATIONALLICENCE 700 1- Ferreira S. Faculty of Health Sciences, Fernando Pessoa University, Rua Carlos da Maia, 296, Office S.1, 4200-150, Porto, Portugal aut NATIONALLICENCE 700 1- Basso R. Department of Plastic Surgery, School of Medicine, University of Campinas-Unicamp, 13083-970, Campinas, Brazil aut NATIONALLICENCE 700 1- Chaud M. Laboratory for Development and Evaluation of Bioactive Substance, Sorocaba University (UNISO), 18023-000, Sorocaba, Brazil aut NATIONALLICENCE 700 1- Santana M. Department of Biotechnological Processes, School of Engineering Chemical, University of Campinas-Unicamp, 13083-970, Campinas, Brazil aut NATIONALLICENCE 700 1- Rosmaninho A. Department of Dermatology, Hospital Santo Antonio, CHP-EPE, Porto, Portugal aut NATIONALLICENCE 700 1- Souto E. Faculty of Health Sciences, Fernando Pessoa University, Rua Carlos da Maia, 296, Office S.1, 4200-150, Porto, Portugal aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/6(2013-06-01), 417-424 1699-048X 15:6<417 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer