naa a22 4500 510763243 CHVBK 20180411083147.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s12094-012-0949-1 doi (NATIONALLICENCE)springer-10.1007/s12094-012-0949-1 Intraoperative radiotherapy for the treatment of resectable locally advanced gastric adenocarcinoma: topography of locoregional recurrences and long-term outcomes [Elektronische Daten] [F. Calvo, C. Sole, R. Obregón, M. Gómez-Espí, C. González- San Segundo, L. González- Bayón, E. Alvarez, J. García-Sabrido] Introduction: To report feasibility, tolerance, anatomical sites of upper abdominal locoregional recurrence and long-term outcome of gastric cancer patients treated with surgery and a component of intraoperative electron beam radiotherapy (IORT). Materials and methods: From January 1995 to December 2010, 32 patients with primary gastric adenocarcinoma treated with curative resection (R0) [total gastrectomy (n=9; 28%), subtotal (n=23; 72%) and D2 lymphadenectomy in all patients] and apparent disease confined to locoregional area [Stage: II (n=15; 47%), III (n=17; 53%)] were treated with a component of IORT (IORT applicator size 5-9cm in diameter, dose 10-15Gy, beam energy 6-5MeV) over the celiac axis and peripancreatic nodal areas. Sixteen (50%) patients also received adjuvant treatment (external beam radiotherapy n=6, chemoradiation n=9, chemotherapy alone n=1). Results: With a median follow-up time of 40months (range, 2-60), locoregional recurrence was observed in five (16%) patients (4 nodal in hepatic hilum and 1 anastomotic). Only pN1 patients developed locoregional relapse. No recurrence was observed in the IORT-treated target volume (celiac trunk and peripancreatic nodes). Overall survival at 5years was 54.6% (95% CI: 48.57-60.58). Postoperative mortality was 6% (n=2) and postoperative complications 19% (n=6). Conclusions: It is feasible to integrate IORT as a component of radiotherapy in combined modality therapy of gastric cancer. Local control is high in the radiation boosted area, but marginal regional extension (in particular, involving the hepatic hilum) might be considered as part of the anatomic IORT target volume at risk in pN+ patients. Federación de Sociedades Españolas de Oncología (FESEO), 2012 Intraoperative radiotherapy nationallicence Gastric adenocarcinoma nationallicence Locoregional recurrence nationallicence Calvo F. Department of Oncology, Hospital General Universitario Gregorio Marañón, C/Doctor Esquerdo 46, 28007, Madrid, Spain aut Sole C. Department of Oncology, Hospital General Universitario Gregorio Marañón, C/Doctor Esquerdo 46, 28007, Madrid, Spain aut Obregón R. Service of General Surgery III, Hospital General Universitario Gregorio Marañón, Madrid, Spain aut Gómez-Espí M. Service of Radiation Oncology, Hospital General Universitario Gregorio Marañón, Madrid, Spain aut González- San Segundo C. Service of Radiation Oncology, Hospital General Universitario Gregorio Marañón, Madrid, Spain aut González- Bayón L. Service of General Surgery III, Hospital General Universitario Gregorio Marañón, Madrid, Spain aut Alvarez E. Department of Pathology, Hospital General Universitario Gregorio Marañón, Madrid, Spain aut García-Sabrido J. Service of General Surgery III, Hospital General Universitario Gregorio Marañón, Madrid, Spain aut Clinical and Translational Oncology Springer Milan 15/6(2013-06-01), 443-449 1699-048X 15:6<443 2013 15 12094 https://doi.org/10.1007/s12094-012-0949-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-012-0949-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Calvo F. Department of Oncology, Hospital General Universitario Gregorio Marañón, C/Doctor Esquerdo 46, 28007, Madrid, Spain aut NATIONALLICENCE 700 1- Sole C. Department of Oncology, Hospital General Universitario Gregorio Marañón, C/Doctor Esquerdo 46, 28007, Madrid, Spain aut NATIONALLICENCE 700 1- Obregón R. Service of General Surgery III, Hospital General Universitario Gregorio Marañón, Madrid, Spain aut NATIONALLICENCE 700 1- Gómez-Espí M. Service of Radiation Oncology, Hospital General Universitario Gregorio Marañón, Madrid, Spain aut NATIONALLICENCE 700 1- González- San Segundo C. Service of Radiation Oncology, Hospital General Universitario Gregorio Marañón, Madrid, Spain aut NATIONALLICENCE 700 1- González- Bayón L. Service of General Surgery III, Hospital General Universitario Gregorio Marañón, Madrid, Spain aut NATIONALLICENCE 700 1- Alvarez E. Department of Pathology, Hospital General Universitario Gregorio Marañón, Madrid, Spain aut NATIONALLICENCE 700 1- García-Sabrido J. Service of General Surgery III, Hospital General Universitario Gregorio Marañón, Madrid, Spain aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/6(2013-06-01), 443-449 1699-048X 15:6<443 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer