naa a22 4500 510763308 CHVBK 20180411083147.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s12094-012-0950-8 doi (NATIONALLICENCE)springer-10.1007/s12094-012-0950-8 Pilot study of feasibility and dosimetric comparison of prone versus supine breast radiotherapy [Elektronische Daten] [E. Fernández-Lizarbe, A. Montero, A. Polo, R. Hernanz, R. Morís, S. Formenti, A. Ramos] Purpose: The aim of this study was to demonstrate feasibility and analyze dosimetric differences in prone and supine position breast cancer radiotherapy in women with large or pendulous breast. Methods: Ten post-lumpectomy breast cancer patients underwent supine and prone computed tomography-based treatment plan. On each data set, the whole breast, the ipsilateral lung and the heart were outlined. Multisegment tangential-fields plans were generated for each position. Target coverage, homogeneity, overdosage outside breast and organ at risk sparing were analyzed and compared for supine and prone position. Results: Coverage and dose homogeneity of the PTV measured by D 90 and V 95% were similar for both plans although breast maximum dose was higher in the supine plan (p=0.017). Prone position reduced the percentage of ipsilateral lung receiving 20Gy (V 20Gy) from 26.5 to 2.9% (p=0.007), medium lung dose, as well as the percentage of the heart receiving 35Gy heart (V 35Gy) from 3.4 to 1.2% (p=0.038). Overdosage of areas outside breast PTV was also consistently reduced with prone position (p=0.012). In addition, average number of segments and monitor units needed was reduced in prone position. Conclusions: Prone position in large breast women appears to favor normal tissue sparing in breast radiotherapy as compared to supine position, without diminishing the target coverage. Federación de Sociedades Españolas de Oncología (FESEO), 2012 Breast radiotherapy nationallicence Prone positioning nationallicence Dosimetric analysis nationallicence Normal-tissue sparing nationallicence Fernández-Lizarbe E. Department of Radiation Oncology, University Hospital Ramón y Cajal, Cta. Colmenar Viejo, km 9.100, 28034, Madrid, Spain aut Montero A. Department of Radiation Oncology, University Hospital Ramón y Cajal, Cta. Colmenar Viejo, km 9.100, 28034, Madrid, Spain aut Polo A. Department of Radiation Oncology, University Hospital Ramón y Cajal, Cta. Colmenar Viejo, km 9.100, 28034, Madrid, Spain aut Hernanz R. Department of Radiation Oncology, University Hospital Ramón y Cajal, Cta. Colmenar Viejo, km 9.100, 28034, Madrid, Spain aut Morís R. Department of Radiation Oncology, University Hospital Ramón y Cajal, Cta. Colmenar Viejo, km 9.100, 28034, Madrid, Spain aut Formenti S. Department of Radiation Oncology, New York University (NYU) School of Medicine, Langone Medical Center, New York, NY, USA aut Ramos A. Department of Radiation Oncology, University Hospital Ramón y Cajal, Cta. Colmenar Viejo, km 9.100, 28034, Madrid, Spain aut Clinical and Translational Oncology Springer Milan 15/6(2013-06-01), 450-459 1699-048X 15:6<450 2013 15 12094 https://doi.org/10.1007/s12094-012-0950-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-012-0950-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fernández-Lizarbe E. Department of Radiation Oncology, University Hospital Ramón y Cajal, Cta. Colmenar Viejo, km 9.100, 28034, Madrid, Spain aut NATIONALLICENCE 700 1- Montero A. Department of Radiation Oncology, University Hospital Ramón y Cajal, Cta. Colmenar Viejo, km 9.100, 28034, Madrid, Spain aut NATIONALLICENCE 700 1- Polo A. Department of Radiation Oncology, University Hospital Ramón y Cajal, Cta. Colmenar Viejo, km 9.100, 28034, Madrid, Spain aut NATIONALLICENCE 700 1- Hernanz R. Department of Radiation Oncology, University Hospital Ramón y Cajal, Cta. Colmenar Viejo, km 9.100, 28034, Madrid, Spain aut NATIONALLICENCE 700 1- Morís R. Department of Radiation Oncology, University Hospital Ramón y Cajal, Cta. Colmenar Viejo, km 9.100, 28034, Madrid, Spain aut NATIONALLICENCE 700 1- Formenti S. Department of Radiation Oncology, New York University (NYU) School of Medicine, Langone Medical Center, New York, NY, USA aut NATIONALLICENCE 700 1- Ramos A. Department of Radiation Oncology, University Hospital Ramón y Cajal, Cta. Colmenar Viejo, km 9.100, 28034, Madrid, Spain aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/6(2013-06-01), 450-459 1699-048X 15:6<450 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer