naa a22 4500 510763340 CHVBK 20180411083147.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s12094-012-0997-6 doi (NATIONALLICENCE)springer-10.1007/s12094-012-0997-6 Defining prognostic factors of survival after external beam radiotherapy treatment of hepatocellular carcinoma with lymph node metastases [Elektronische Daten] [Y.-X. Chen, Z.-C. Zeng, J. Fan, Z.-Y. Tang, J. Zhou, M.-S. Zeng, J.-Y. Zhang, J. Sun] Purpose: To identify independent predictors of survival in patients with lymph node (LN) metastases from hepatocellular carcinoma (HCC) after external beam radiotherapy (EBRT). Methods: There were 191 patients with LN metastases from HCC received EBRT enrolled in the study cohort. EBRT was designed to focus on the LNs and a median dose of 50Gy (range 40-60Gy) was delivered. Treatment response was assessed by the WHO response criteria. Factors such as demographic data, tumor characteristics, and treatment modalities were determined before EBRT. Predictors of survival were identified by univariate and multivariate analysis. Results: The median survival was 8.0months for all patients. Factors including Child-Pugh status (p=0.009), intrahepatic tumor control (p=0.015), LN location (p=0.015), and response to EBRT (p<0.001) were significant prognostic factors predicting for survival by multivariate analysis. The objective regression rate (ORR), which is the sum of complete and partial response rates, was as high as 79.1%. As determined by multivariate analysis, the factors of LN location near liver (p=0.002), smaller LN size (p=0.021), and higher EBRT dose (p<0.001) were associated with higher ORR values. Conclusion: This study provides detailed information about survival outcomes and prognostic factors. Child-Pugh B value, uncontrolled intrahepatic tumor, LN location far from liver, and no response to EBRT are the unfavorable independent predictors. Federación de Sociedades Españolas de Oncología (FESEO), 2013 Hepatocellular carcinoma nationallicence External beam radiotherapy nationallicence Prognostic nationallicence Lymph node nationallicence Metastasis nationallicence Chen Y.-X Department of Radiation Oncology, Zhongshan Hospital, Fudan University, 136 Yi Xue Yuan Road, 200032, Shanghai, China aut Zeng Z.-C Department of Radiation Oncology, Zhongshan Hospital, Fudan University, 136 Yi Xue Yuan Road, 200032, Shanghai, China aut Fan J. Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China aut Tang Z.-Y Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China aut Zhou J. Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China aut Zeng M.-S Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China aut Zhang J.-Y Department of Radiation Oncology, Zhongshan Hospital, Fudan University, 136 Yi Xue Yuan Road, 200032, Shanghai, China aut Sun J. Department of Radiation Oncology, Zhongshan Hospital, Fudan University, 136 Yi Xue Yuan Road, 200032, Shanghai, China aut Clinical and Translational Oncology Springer Milan 15/9(2013-09-01), 732-740 1699-048X 15:9<732 2013 15 12094 https://doi.org/10.1007/s12094-012-0997-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-012-0997-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chen Y.-X Department of Radiation Oncology, Zhongshan Hospital, Fudan University, 136 Yi Xue Yuan Road, 200032, Shanghai, China aut NATIONALLICENCE 700 1- Zeng Z.-C Department of Radiation Oncology, Zhongshan Hospital, Fudan University, 136 Yi Xue Yuan Road, 200032, Shanghai, China aut NATIONALLICENCE 700 1- Fan J. Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China aut NATIONALLICENCE 700 1- Tang Z.-Y Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China aut NATIONALLICENCE 700 1- Zhou J. Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China aut NATIONALLICENCE 700 1- Zeng M.-S Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China aut NATIONALLICENCE 700 1- Zhang J.-Y Department of Radiation Oncology, Zhongshan Hospital, Fudan University, 136 Yi Xue Yuan Road, 200032, Shanghai, China aut NATIONALLICENCE 700 1- Sun J. Department of Radiation Oncology, Zhongshan Hospital, Fudan University, 136 Yi Xue Yuan Road, 200032, Shanghai, China aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/9(2013-09-01), 732-740 1699-048X 15:9<732 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer