naa a22 4500 510763359 CHVBK 20180411083147.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s12094-012-0990-0 doi (NATIONALLICENCE)springer-10.1007/s12094-012-0990-0 Clinical and prognostic usefulness of serum proteomic profile in hepatic colorectal metastases: a pilot prospective study [Elektronische Daten] [J. Martí, J. Fuster, J. Estanyol, F. Fernández, R. Deulofeu, J. Ferrer, A. Pelegrina, A. Reyes, C. Fondevila, J. García-Valdecasas] Purpose: To analyze the use of proteomic profiles to discriminate healthy from patients with colorectal liver metastases (CLM) and to predict neoplastic recurrence after CLM resection. Methods: From April 2005 to October 2008, 70 patients operated for first curative resection of CLM and 60 healthy controls underwent determination of preoperative serum proteomic profile. We performed a preliminary training with patients and controls and obtained a classification system based on these patients' proteomic profiles training. The system was then tested about the ability to predict the colon versus rectum origin, metachronous or synchronous appearance, risk of recurrence after CLM resection and whether a sample was from a control or a CLM patient. Results: Sensitivity, specificity, positive and negative predictive values for detecting CLM patients were 75, 100, 100 and 54.6%, respectively. Best CLM appearance time identification was 50% and primary tumor origin identification was 62.5%. Best classifications of neoplastic recurrence within the first year after CLM resection and during the follow-up period were 47.5 and 45%, respectively. Larger training sets and prevalence-based training sets led to better classification of patients and characteristics. Conclusion: Proteomic profiles are a promising tool for discriminating CLM patients from healthy patients and for predicting neoplastic recurrence. Federación de Sociedades Españolas de Oncología (FESEO), 2013 Colorectal cancer nationallicence Liver metastases nationallicence Prognosis nationallicence Proteomic analysis nationallicence Proteomic profile nationallicence Martí J. Liver Surgery and Transplantation Unit, Digestive and Metabolism Diseases Clinical Institute, IDIBAPS, Hospital Clinic and Provincial, CIBERehd, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut Fuster J. Liver Surgery and Transplantation Unit, Digestive and Metabolism Diseases Clinical Institute, IDIBAPS, Hospital Clinic and Provincial, CIBERehd, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut Estanyol J. Proteomic Unit, Scientifical and Technological Centre, University of Barcelona, Casanova 143, 08036, Barcelona, Spain aut Fernández F. Proteomic Unit, Scientifical and Technological Centre, University of Barcelona, Casanova 143, 08036, Barcelona, Spain aut Deulofeu R. Biochemistry Department, Hospital Clinic and Provincial, CIBERehd, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut Ferrer J. Liver Surgery and Transplantation Unit, Digestive and Metabolism Diseases Clinical Institute, IDIBAPS, Hospital Clinic and Provincial, CIBERehd, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut Pelegrina A. Liver Surgery and Transplantation Unit, Digestive and Metabolism Diseases Clinical Institute, IDIBAPS, Hospital Clinic and Provincial, CIBERehd, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut Reyes A. Liver Surgery and Transplantation Unit, Digestive and Metabolism Diseases Clinical Institute, IDIBAPS, Hospital Clinic and Provincial, CIBERehd, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut Fondevila C. Liver Surgery and Transplantation Unit, Digestive and Metabolism Diseases Clinical Institute, IDIBAPS, Hospital Clinic and Provincial, CIBERehd, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut García-Valdecasas J. Liver Surgery and Transplantation Unit, Digestive and Metabolism Diseases Clinical Institute, IDIBAPS, Hospital Clinic and Provincial, CIBERehd, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut Clinical and Translational Oncology Springer Milan 15/9(2013-09-01), 691-697 1699-048X 15:9<691 2013 15 12094 https://doi.org/10.1007/s12094-012-0990-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-012-0990-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Martí J. Liver Surgery and Transplantation Unit, Digestive and Metabolism Diseases Clinical Institute, IDIBAPS, Hospital Clinic and Provincial, CIBERehd, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Fuster J. Liver Surgery and Transplantation Unit, Digestive and Metabolism Diseases Clinical Institute, IDIBAPS, Hospital Clinic and Provincial, CIBERehd, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Estanyol J. Proteomic Unit, Scientifical and Technological Centre, University of Barcelona, Casanova 143, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Fernández F. Proteomic Unit, Scientifical and Technological Centre, University of Barcelona, Casanova 143, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Deulofeu R. Biochemistry Department, Hospital Clinic and Provincial, CIBERehd, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Ferrer J. Liver Surgery and Transplantation Unit, Digestive and Metabolism Diseases Clinical Institute, IDIBAPS, Hospital Clinic and Provincial, CIBERehd, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Pelegrina A. Liver Surgery and Transplantation Unit, Digestive and Metabolism Diseases Clinical Institute, IDIBAPS, Hospital Clinic and Provincial, CIBERehd, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Reyes A. Liver Surgery and Transplantation Unit, Digestive and Metabolism Diseases Clinical Institute, IDIBAPS, Hospital Clinic and Provincial, CIBERehd, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Fondevila C. Liver Surgery and Transplantation Unit, Digestive and Metabolism Diseases Clinical Institute, IDIBAPS, Hospital Clinic and Provincial, CIBERehd, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- García-Valdecasas J. Liver Surgery and Transplantation Unit, Digestive and Metabolism Diseases Clinical Institute, IDIBAPS, Hospital Clinic and Provincial, CIBERehd, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/9(2013-09-01), 691-697 1699-048X 15:9<691 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer