naa a22 4500 510763367 CHVBK 20180411083147.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s12094-012-0992-y doi (NATIONALLICENCE)springer-10.1007/s12094-012-0992-y Clinical target volume definition for glioblastoma radiotherapy planning: magnetic resonance imaging and computed tomography [Elektronische Daten] [A. Fiorentino, R. Caivano, P. Pedicini, V. Fusco] Purpose: To assess the differences between the target delineation using computed tomography (CT) and imaging fusion CT/magnetic resonance imaging (MRI) for the radiotherapy planning of glioblastoma. Methods: One hundred-twenty gross tumor volume and clinical target volume on CT and MRI (GTVCT/CTVCT, GTVMRI/CTVMRI, respectively) were contoured and evaluated. The treatments planning (total dose 60Gy) based on CTVCT were analysed in terms of percentage of CTVCT and CTVMRI receiving 95% of the prescribed dose (V95-CTVCT, V95-CTVMRI). Results: GTVs and CTVs contoured on MRI were significantly larger than those delineated on CT (p=0.0003, p=0.0006, respectively). Nighty-two percent of CTVCT was coincident with the CTVMRI and 8% was normal tissue; 20% of CTVMRI, considered as tumor volume, was not included on CTVCT. The V95-CTVMRI was significantly lower than the V95-CTVCT (p=0.0005). Conclusions: In the delineation of glioblastoma target volume, fusion CT/MRI was preferred. The CT only is insufficient for the CTV dose coverage. Federación de Sociedades Españolas de Oncología (FESEO), 2013 Glioblastoma nationallicence Target nationallicence Radiotherapy nationallicence CT nationallicence MRI nationallicence Imaging nationallicence Fiorentino A. Department of Radiation Oncology, IRCCS/CROB, via San Pio 1, 85028, Rionero in Vulture, PZ, Italy aut Caivano R. Department of Radiation Oncology, IRCCS/CROB, via San Pio 1, 85028, Rionero in Vulture, PZ, Italy aut Pedicini P. Department of Radiation Oncology, IRCCS/CROB, via San Pio 1, 85028, Rionero in Vulture, PZ, Italy aut Fusco V. Department of Radiation Oncology, IRCCS/CROB, via San Pio 1, 85028, Rionero in Vulture, PZ, Italy aut Clinical and Translational Oncology Springer Milan 15/9(2013-09-01), 754-758 1699-048X 15:9<754 2013 15 12094 https://doi.org/10.1007/s12094-012-0992-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-012-0992-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fiorentino A. Department of Radiation Oncology, IRCCS/CROB, via San Pio 1, 85028, Rionero in Vulture, PZ, Italy aut NATIONALLICENCE 700 1- Caivano R. Department of Radiation Oncology, IRCCS/CROB, via San Pio 1, 85028, Rionero in Vulture, PZ, Italy aut NATIONALLICENCE 700 1- Pedicini P. Department of Radiation Oncology, IRCCS/CROB, via San Pio 1, 85028, Rionero in Vulture, PZ, Italy aut NATIONALLICENCE 700 1- Fusco V. Department of Radiation Oncology, IRCCS/CROB, via San Pio 1, 85028, Rionero in Vulture, PZ, Italy aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/9(2013-09-01), 754-758 1699-048X 15:9<754 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer