naa a22 4500 510763375 CHVBK 20180411083147.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s12094-012-0996-7 doi (NATIONALLICENCE)springer-10.1007/s12094-012-0996-7 Management of malignant insulinoma [Elektronische Daten] [J. Ferrer-García, V. Iranzo González-Cruz, S. Navas-DeSolís, M. Civera-Andrés, C. Morillas-Ariño, Á. Merchante-Alfaro, C. Caballero-Díaz, C. Sánchez-Juan, C. Camps Herrero] Aim: Malignant insulinoma is an infrequent functional endocrine tumor of the pancreas. Adequate therapy is a demanding challenge for oncologists and endocrinologists. Objective: To evaluate the results of multidisciplinary management of malignant insulinoma. Materials and methods: Retrospective review of patients with malignant insulinoma treated from 1995 to 2011. Results: Seven patients with malignant insulinoma were included: four males and three females; median age was 61.8years (range 37-78). Six tumors were sporadic and one was diagnosed in a patient with a type 1 multiple endocrine neoplasia (MEN-1). Surgery was performed in six cases and one patient was considered unresectable. Hypoglycemias persisted in all cases and somatostatin analogs, glucocorticoids and diazoxide were used. Two patients received everolimus. Other techniques were chemoembolization and internal radiation therapy with yttrium-90. Successful liver transplant was done in the patient with MEN-1. Conclusion: Hypoglycemia management is complex and requires multiple therapies. Further evaluations will be necessary to determine the best treatment. Federación de Sociedades Españolas de Oncología (FESEO), 2013 Insulinoma nationallicence Neuroendocrine pancreatic tumor nationallicence Hypoglycemia nationallicence Islet cell tumors nationallicence Ferrer-García J. Department of Endocrinology and Nutrition, Consorcio Hospital General Universitario de Valencia, Valencia, Spain aut Iranzo González-Cruz V. Department of Oncology, Consorcio Hospital General Universitario de Valencia, Avda. Tres Cruces, 2, 46014, Valencia, Spain aut Navas-DeSolís S. Department of Endocrinology and Nutrition, Hospital Universitario La Fe, Valencia, Spain aut Civera-Andrés M. Department of Endocrinology and Nutrition, Hospital Clínico Universitario, Valencia, Spain aut Morillas-Ariño C. Department of Endocrinology and Nutrition, Hospital Universitario Doctor Peset, Valencia, Spain aut Merchante-Alfaro Á. Department of Endocrinology and Nutrition, Consorcio Hospital General Universitario de Valencia, Valencia, Spain aut Caballero-Díaz C. Department of Oncology, Consorcio Hospital General Universitario de Valencia, Avda. Tres Cruces, 2, 46014, Valencia, Spain aut Sánchez-Juan C. Department of Endocrinology and Nutrition, Consorcio Hospital General Universitario de Valencia, Valencia, Spain aut Camps Herrero C. Department of Oncology, Consorcio Hospital General Universitario de Valencia, Avda. Tres Cruces, 2, 46014, Valencia, Spain aut Clinical and Translational Oncology Springer Milan 15/9(2013-09-01), 725-731 1699-048X 15:9<725 2013 15 12094 https://doi.org/10.1007/s12094-012-0996-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-012-0996-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ferrer-García J. Department of Endocrinology and Nutrition, Consorcio Hospital General Universitario de Valencia, Valencia, Spain aut NATIONALLICENCE 700 1- Iranzo González-Cruz V. Department of Oncology, Consorcio Hospital General Universitario de Valencia, Avda. Tres Cruces, 2, 46014, Valencia, Spain aut NATIONALLICENCE 700 1- Navas-DeSolís S. Department of Endocrinology and Nutrition, Hospital Universitario La Fe, Valencia, Spain aut NATIONALLICENCE 700 1- Civera-Andrés M. Department of Endocrinology and Nutrition, Hospital Clínico Universitario, Valencia, Spain aut NATIONALLICENCE 700 1- Morillas-Ariño C. Department of Endocrinology and Nutrition, Hospital Universitario Doctor Peset, Valencia, Spain aut NATIONALLICENCE 700 1- Merchante-Alfaro Á. Department of Endocrinology and Nutrition, Consorcio Hospital General Universitario de Valencia, Valencia, Spain aut NATIONALLICENCE 700 1- Caballero-Díaz C. Department of Oncology, Consorcio Hospital General Universitario de Valencia, Avda. Tres Cruces, 2, 46014, Valencia, Spain aut NATIONALLICENCE 700 1- Sánchez-Juan C. Department of Endocrinology and Nutrition, Consorcio Hospital General Universitario de Valencia, Valencia, Spain aut NATIONALLICENCE 700 1- Camps Herrero C. Department of Oncology, Consorcio Hospital General Universitario de Valencia, Avda. Tres Cruces, 2, 46014, Valencia, Spain aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/9(2013-09-01), 725-731 1699-048X 15:9<725 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer