naa a22 4500 510763391 CHVBK 20180411083147.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s12094-012-0998-5 doi (NATIONALLICENCE)springer-10.1007/s12094-012-0998-5 Beam angle selection for intensity-modulated radiotherapy (IMRT) treatment of unresectable pancreatic cancer: are noncoplanar beam angles necessary? [Elektronische Daten] [D. Chang, G. Bartlett, I. Das, H. Cardenes] Background and purpose: External beam radiation therapy with concurrent chemotherapy (CRT) is widely used for the treatment of unresectable pancreatic cancer. Noncoplanar (NCP) 3D conformal radiotherapy (3DCRT) and coplanar (CP) IMRT have been reported to lower the radiation dose to organs at risk (OARs). The purpose of this article is to examine the utility of noncoplanar beam angles in IMRT for the management of pancreatic cancer. Materials and methods: Sixteen patients who were treated with CRT for unresectable adenocarcinoma of the pancreatic head or neck were re-planned using CP and NCP beams in 3DCRT and IMRT with the Varian Eclipse treatment planning system. Results: Compared to CP IMRT, NCP IMRT had similar target coverage with slightly increased maximum point dose, 5,799 versus 5,775cGy (p=0.008). NCP IMRT resulted in lower mean kidney dose, 787 versus 1,210cGy (p<0.0001) and higher mean liver dose, 1,208 versus 1,061cGy (p<0.0001). Also, NCP IMRT resulted in similar mean stomach dose, 1,257 versus 1,248cGy (p=0.86) but slightly higher mean small bowel dose, 981 versus 866cGy (p<0.0001). Conclusions: The NCP IMRT was able to significantly decrease bilateral kidney dose, but did not improve other dose-volume criteria. The use of NCP beam angles is preferred only in patients with risk factors for treatment-related kidney dysfunction. Federación de Sociedades Españolas de Oncología (FESEO), 2013 Pancreatic cancer nationallicence IMRT nationallicence Noncoplanar fields nationallicence Dosimetric comparison nationallicence Treatment technique nationallicence Chang D. Department of Radiation Oncology, IU Simon Cancer Center, Indiana University School of Medicine, 535 Barnhill Dr., RT 041, 46202, Indianapolis, IN, USA aut Bartlett G. Department of Radiation Oncology, IU Simon Cancer Center, Indiana University School of Medicine, 535 Barnhill Dr., RT 041, 46202, Indianapolis, IN, USA aut Das I. Department of Radiation Oncology, IU Simon Cancer Center, Indiana University School of Medicine, 535 Barnhill Dr., RT 041, 46202, Indianapolis, IN, USA aut Cardenes H. Department of Radiation Oncology, IU Simon Cancer Center, Indiana University School of Medicine, 535 Barnhill Dr., RT 041, 46202, Indianapolis, IN, USA aut Clinical and Translational Oncology Springer Milan 15/9(2013-09-01), 720-724 1699-048X 15:9<720 2013 15 12094 https://doi.org/10.1007/s12094-012-0998-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-012-0998-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chang D. Department of Radiation Oncology, IU Simon Cancer Center, Indiana University School of Medicine, 535 Barnhill Dr., RT 041, 46202, Indianapolis, IN, USA aut NATIONALLICENCE 700 1- Bartlett G. Department of Radiation Oncology, IU Simon Cancer Center, Indiana University School of Medicine, 535 Barnhill Dr., RT 041, 46202, Indianapolis, IN, USA aut NATIONALLICENCE 700 1- Das I. Department of Radiation Oncology, IU Simon Cancer Center, Indiana University School of Medicine, 535 Barnhill Dr., RT 041, 46202, Indianapolis, IN, USA aut NATIONALLICENCE 700 1- Cardenes H. Department of Radiation Oncology, IU Simon Cancer Center, Indiana University School of Medicine, 535 Barnhill Dr., RT 041, 46202, Indianapolis, IN, USA aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/9(2013-09-01), 720-724 1699-048X 15:9<720 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer