naa a22 4500 510763502 CHVBK 20180411083148.0 cr unu---uuuuu 180411e20130701xx s 000 0 eng 10.1007/s12094-012-0965-1 doi (NATIONALLICENCE)springer-10.1007/s12094-012-0965-1 Management and outcome of ovarian malignancy complicating pregnancy: an analysis of 41 cases and review of the literature [Elektronische Daten] [T. Gui, D. Cao, K. Shen, J. Yang, C. Fu, J. Lang, X. Liu] Objective: The aims of this study are to summarize our experience of managing ovarian malignancy complicating pregnancy, to discuss the maternal and fetal outcomes, and to review the literature concerned. Methods: Forty-one patients with ovarian malignancies complicating pregnancy at Peking Union Medical College Hospital between 1990 and 2012 were retrospectively reviewed. Results: Of the 41 patients, malignancies included epithelial ovarian cancers (13/41, 31.7%), epithelial borderline ovarian tumors (12/41, 29.3%), ovarian malignant germ cell tumors (10/41, 24.4%), sexcord stromal tumors (3/41, 7.3%), metastatic ovarian tumors (2/41, 4.9%), and primary ovarian choriocarcinoma (1/41, 2.4%). The median overall survival was 30months (range 3-165), with an overall mortality rate of 24.4%. The pregnancy outcomes included termination in the first trimester (8/41, 19.5%), full-term vaginal delivery (7/41, 17.0%), full-term cesarean section (17/41, 41.5%), and therapeutic cesarean section for premature birth (9/41, 22.0%). One preterm newborn died, and the remaining 32 survived in healthy status. All patients underwent surgery, and those who deliberately delayed radical surgery had gloomy prognosis. Two patients received chemotherapy during pregnancy, and 24 patients started chemotherapy after pregnancy termination. Conclusions: Management priority should be given to the malignancy of ovarian tumors at any stage of pregnancy. Surgical intervention is the main treatment modality, and delaying of radical surgery is not recommended for patients with suspicion of high malignancy. Early diagnosis and appropriate treatment could offer satisfactory prognosis. Federación de Sociedades Españolas de Oncología (FESEO), 2012 Outcome nationallicence Surgery nationallicence Chemotherapy nationallicence Pregnancy nationallicence Ovarian malignancy nationallicence Gui T. Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 100730, Beijing, China aut Cao D. Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 100730, Beijing, China aut Shen K. Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 100730, Beijing, China aut Yang J. Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 100730, Beijing, China aut Fu C. Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 100730, Beijing, China aut Lang J. Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 100730, Beijing, China aut Liu X. Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 100730, Beijing, China aut Clinical and Translational Oncology Springer Milan 15/7(2013-07-01), 548-554 1699-048X 15:7<548 2013 15 12094 https://doi.org/10.1007/s12094-012-0965-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-012-0965-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gui T. Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 100730, Beijing, China aut NATIONALLICENCE 700 1- Cao D. Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 100730, Beijing, China aut NATIONALLICENCE 700 1- Shen K. Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 100730, Beijing, China aut NATIONALLICENCE 700 1- Yang J. Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 100730, Beijing, China aut NATIONALLICENCE 700 1- Fu C. Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 100730, Beijing, China aut NATIONALLICENCE 700 1- Lang J. Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 100730, Beijing, China aut NATIONALLICENCE 700 1- Liu X. Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 100730, Beijing, China aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/7(2013-07-01), 548-554 1699-048X 15:7<548 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer