naa a22 4500 510763529 CHVBK 20180411083148.0 cr unu---uuuuu 180411e20130701xx s 000 0 eng 10.1007/s12094-012-0960-6 doi (NATIONALLICENCE)springer-10.1007/s12094-012-0960-6 Comparison of second-line treatment outcomes between sensitive and refractory small cell lung cancer patients: a retrospective analysis [Elektronische Daten] [T. Korkmaz, S. Seber, U. Kefeli, E. Sari, M. Canhoroz, B. Oven, E. Yildirim, N. Yasar, D. Aydin, O. Balvan, N. Sener, S. Yuksel, A. Mert, O. Polat, F. Yumuk, O. Kanat, M. Gumus, N. Turhal] Purpose: Small cell lung cancer (SCLC) has a high relapse rate despite being very chemosensitive. The efficacy of second-line treatment is dismal. Our aim was to evaluate the outcome of second-line treatment. Methods: We retrospectively assessed data of 120 SCLC patients who failed first-line treatment and received second-line treatment at three medical oncology centers. Results: Median age of group was 58. 82% had an ECOG PS of 0-1 at the time of relapse. 39% were at limited stage (LS) at the time of diagnosis. Patients who progressed more than 3months after first-line therapy were categorized as having platinum-sensitive disease (PSD) (64%). The number of patients who received platin-based combination treatment was 33 (27%). The median OS time starting from the initiation of second-line treatment was 7months. Multivariate analysis identified PS (p=0.006), extent of disease at diagnosis (0.014) and PSD (0.001) as the independent prognostic factors for survival. Subgroup analyses of the patients with PSD indicated platin rechallenge yields higher progression-free survival, overall survival and overall response rate. Conclusion: Patients with good ECOG PS,who have PSD or initially presenting with LS, have a good prognosis and in patients with PSD, platinum-based therapy would be more appropriate. Federación de Sociedades Españolas de Oncología (FESEO), 2012 Platinum sensitive disease nationallicence Platinum refracter disease nationallicence Second-line chemotherapy nationallicence Small cell lung cancer nationallicence Korkmaz T. Department of Medical Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, žemsi Denizer Cad. E-5 Karayolu Cevizli Mevkii, 34890, Kartal/Istanbul, Turkey aut Seber S. Medical Oncology Department, Marmara University Hospital, Istanbul, Turkey aut Kefeli U. Department of Medical Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, žemsi Denizer Cad. E-5 Karayolu Cevizli Mevkii, 34890, Kartal/Istanbul, Turkey aut Sari E. Department of Medical Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, žemsi Denizer Cad. E-5 Karayolu Cevizli Mevkii, 34890, Kartal/Istanbul, Turkey aut Canhoroz M. Medical Oncology Department, Uludag University Hospital, Bursa, Turkey aut Oven B. Department of Medical Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, žemsi Denizer Cad. E-5 Karayolu Cevizli Mevkii, 34890, Kartal/Istanbul, Turkey aut Yildirim E. Department of Medical Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, žemsi Denizer Cad. E-5 Karayolu Cevizli Mevkii, 34890, Kartal/Istanbul, Turkey aut Yasar N. Department of Medical Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, žemsi Denizer Cad. E-5 Karayolu Cevizli Mevkii, 34890, Kartal/Istanbul, Turkey aut Aydin D. Department of Medical Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, žemsi Denizer Cad. E-5 Karayolu Cevizli Mevkii, 34890, Kartal/Istanbul, Turkey aut Balvan O. Department of Medical Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, žemsi Denizer Cad. E-5 Karayolu Cevizli Mevkii, 34890, Kartal/Istanbul, Turkey aut Sener N. Department of Medical Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, žemsi Denizer Cad. E-5 Karayolu Cevizli Mevkii, 34890, Kartal/Istanbul, Turkey aut Yuksel S. Department of Medical Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, žemsi Denizer Cad. E-5 Karayolu Cevizli Mevkii, 34890, Kartal/Istanbul, Turkey aut Mert A. Department of Medical Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, žemsi Denizer Cad. E-5 Karayolu Cevizli Mevkii, 34890, Kartal/Istanbul, Turkey aut Polat O. Internal Medicine Department, Marmara University Hospital, Istanbul, Turkey aut Yumuk F. Medical Oncology Department, Marmara University Hospital, Istanbul, Turkey aut Kanat O. Medical Oncology Department, Uludag University Hospital, Bursa, Turkey aut Gumus M. Department of Medical Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, žemsi Denizer Cad. E-5 Karayolu Cevizli Mevkii, 34890, Kartal/Istanbul, Turkey aut Turhal N. Medical Oncology Department, Marmara University Hospital, Istanbul, Turkey aut Clinical and Translational Oncology Springer Milan 15/7(2013-07-01), 535-540 1699-048X 15:7<535 2013 15 12094 https://doi.org/10.1007/s12094-012-0960-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-012-0960-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Korkmaz T. Department of Medical Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, žemsi Denizer Cad. E-5 Karayolu Cevizli Mevkii, 34890, Kartal/Istanbul, Turkey aut NATIONALLICENCE 700 1- Seber S. Medical Oncology Department, Marmara University Hospital, Istanbul, Turkey aut NATIONALLICENCE 700 1- Kefeli U. Department of Medical Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, žemsi Denizer Cad. E-5 Karayolu Cevizli Mevkii, 34890, Kartal/Istanbul, Turkey aut NATIONALLICENCE 700 1- Sari E. Department of Medical Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, žemsi Denizer Cad. E-5 Karayolu Cevizli Mevkii, 34890, Kartal/Istanbul, Turkey aut NATIONALLICENCE 700 1- Canhoroz M. Medical Oncology Department, Uludag University Hospital, Bursa, Turkey aut NATIONALLICENCE 700 1- Oven B. Department of Medical Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, žemsi Denizer Cad. E-5 Karayolu Cevizli Mevkii, 34890, Kartal/Istanbul, Turkey aut NATIONALLICENCE 700 1- Yildirim E. Department of Medical Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, žemsi Denizer Cad. E-5 Karayolu Cevizli Mevkii, 34890, Kartal/Istanbul, Turkey aut NATIONALLICENCE 700 1- Yasar N. Department of Medical Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, žemsi Denizer Cad. E-5 Karayolu Cevizli Mevkii, 34890, Kartal/Istanbul, Turkey aut NATIONALLICENCE 700 1- Aydin D. Department of Medical Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, žemsi Denizer Cad. E-5 Karayolu Cevizli Mevkii, 34890, Kartal/Istanbul, Turkey aut NATIONALLICENCE 700 1- Balvan O. Department of Medical Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, žemsi Denizer Cad. E-5 Karayolu Cevizli Mevkii, 34890, Kartal/Istanbul, Turkey aut NATIONALLICENCE 700 1- Sener N. Department of Medical Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, žemsi Denizer Cad. E-5 Karayolu Cevizli Mevkii, 34890, Kartal/Istanbul, Turkey aut NATIONALLICENCE 700 1- Yuksel S. Department of Medical Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, žemsi Denizer Cad. E-5 Karayolu Cevizli Mevkii, 34890, Kartal/Istanbul, Turkey aut NATIONALLICENCE 700 1- Mert A. Department of Medical Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, žemsi Denizer Cad. E-5 Karayolu Cevizli Mevkii, 34890, Kartal/Istanbul, Turkey aut NATIONALLICENCE 700 1- Polat O. Internal Medicine Department, Marmara University Hospital, Istanbul, Turkey aut NATIONALLICENCE 700 1- Yumuk F. Medical Oncology Department, Marmara University Hospital, Istanbul, Turkey aut NATIONALLICENCE 700 1- Kanat O. Medical Oncology Department, Uludag University Hospital, Bursa, Turkey aut NATIONALLICENCE 700 1- Gumus M. Department of Medical Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, žemsi Denizer Cad. E-5 Karayolu Cevizli Mevkii, 34890, Kartal/Istanbul, Turkey aut NATIONALLICENCE 700 1- Turhal N. Medical Oncology Department, Marmara University Hospital, Istanbul, Turkey aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/7(2013-07-01), 535-540 1699-048X 15:7<535 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer