naa a22 4500 51076374X CHVBK 20180411083149.0 cr unu---uuuuu 180411e20130301xx s 000 0 eng 10.1007/s12094-012-0924-x doi (NATIONALLICENCE)springer-10.1007/s12094-012-0924-x Novel insight into the role of GAPDH playing in tumor [Elektronische Daten] [Chunmei Guo, Shuqing Liu, Ming-Zhong Sun] The role of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) being consistently regarded as the main housekeeping gene and reference gene/protein for expression quantification in tumors has been gradually questioned and challenged by accumulated experiment evidence. The current review notified that the GAPDH expression was deregulated in lung cancer, renal cancer, breast cancer, gastric cancer, glioma, liver cancer, colorectal cancer, melanoma, prostatic cancer, pancreatic cancer and bladder cancer. Interestingly, GAPDH was commonly up-regulated in a variety of types of cancer, which was revealed to be potentially required for the cancer cell growth and tumor formation. The relevant mechanisms were also discussed in current review. This work might provide useful insights for future studies on GAPDH in tumors. Federación de Sociedades Españolas de Oncología (FESEO), 2012 GAPDH nationallicence Tumor nationallicence Guo Chunmei Department of Biotechnology, Dalian Medical University, 116044, Dalian, China aut Liu Shuqing Department of Biochemistry and Molecular Biology, Dalian Medical University, 116044, Dalian, China aut Sun Ming-Zhong Department of Biotechnology, Dalian Medical University, 116044, Dalian, China aut Clinical and Translational Oncology Springer Milan 15/3(2013-03-01), 167-172 1699-048X 15:3<167 2013 15 12094 https://doi.org/10.1007/s12094-012-0924-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-012-0924-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Guo Chunmei Department of Biotechnology, Dalian Medical University, 116044, Dalian, China aut NATIONALLICENCE 700 1- Liu Shuqing Department of Biochemistry and Molecular Biology, Dalian Medical University, 116044, Dalian, China aut NATIONALLICENCE 700 1- Sun Ming-Zhong Department of Biotechnology, Dalian Medical University, 116044, Dalian, China aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/3(2013-03-01), 167-172 1699-048X 15:3<167 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer