naa a22 4500 510763847 CHVBK 20180411083149.0 cr unu---uuuuu 180411e20131001xx s 000 0 eng 10.1007/s12094-013-1005-5 doi (NATIONALLICENCE)springer-10.1007/s12094-013-1005-5 CUG-binding protein 1 (CUGBP1) expression and prognosis of non-small cell lung cancer [Elektronische Daten] [W. Jiao, J. Zhao, M. Wang, Y. Wang, Y. Luo, Y. Zhao, D. Tang, Y. Shen] Background and aims: Non-small cell lung cancer (NSCLC) is the leading cause of cancer mortality worldwide. As CUGBP1 may also play a great role in tumor genesis and deterioration, the purpose of this study was to detect the expression of CUGBP1 mRNA and CUGBP1 and assess the prognostic significance of CUGBP1 in NSCLC. Methods: Expression of CUGBP1 mRNA and CUGBP was detected by Semi-quantitative PCR and Immunohistochemistry, respectively, from 57 NSCLC patients. The percentage of CUGBP1 mRNA and CUGBP1 expression was correlated with clinical characteristics using χ 2 test. The prognostic significance was assessed by univariate and multivariate analyses in the Cox hazard model. Results: The expression of CUGBP1 mRNA and CUGBP1 was over-expressed in cancer group and was correlated with TNM stage and Differentiation. By both univariate and multivariate survival analyses, CUGBP1 expression (P=0.0074, HR=3.701, 95% CI 1.420-9.648), TNM-stage (HR=4.043, 95% CI 2.098-7.794) and age (HR=3.207, 95% CI 1.544-6.664) were noted to be independent indicators of a shorter postsurgical survival. Conclusions: The expression of CUGBP1 independently predicted a shorter postsurgical survival in NSCLC. Federación de Sociedades Españolas de Oncología (FESEO), 2013 CUGBP1 nationallicence CUGBP1mRNA nationallicence Non-small cell lung cancer nationallicence Prognosis nationallicence Jiao W. Department of Thoracic Surgery, The Affiliated Hospital of Medical College, Qingdao University, 16 Jiangsu Road, 266003, Qingdao, People's Republic of China aut Zhao J. Department of Thoracic Surgery, The Affiliated Hospital of Medical College, Qingdao University, 16 Jiangsu Road, 266003, Qingdao, People's Republic of China aut Wang M. Department of Thoracic Surgery, The Affiliated Hospital of Medical College, Qingdao University, 16 Jiangsu Road, 266003, Qingdao, People's Republic of China aut Wang Y. Department of Thoracic Surgery, The Affiliated Hospital of Medical College, Qingdao University, 16 Jiangsu Road, 266003, Qingdao, People's Republic of China aut Luo Y. Department of Thoracic Surgery, The Affiliated Hospital of Medical College, Qingdao University, 16 Jiangsu Road, 266003, Qingdao, People's Republic of China aut Zhao Y. Department of Thoracic Surgery, The Affiliated Hospital of Medical College, Qingdao University, 16 Jiangsu Road, 266003, Qingdao, People's Republic of China aut Tang D. Department of Thoracic Surgery, The Affiliated Hospital of Medical College, Qingdao University, 16 Jiangsu Road, 266003, Qingdao, People's Republic of China aut Shen Y. Department of Thoracic Surgery, The Affiliated Hospital of Medical College, Qingdao University, 16 Jiangsu Road, 266003, Qingdao, People's Republic of China aut Clinical and Translational Oncology Springer Milan 15/10(2013-10-01), 789-795 1699-048X 15:10<789 2013 15 12094 https://doi.org/10.1007/s12094-013-1005-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-013-1005-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jiao W. Department of Thoracic Surgery, The Affiliated Hospital of Medical College, Qingdao University, 16 Jiangsu Road, 266003, Qingdao, People's Republic of China aut NATIONALLICENCE 700 1- Zhao J. Department of Thoracic Surgery, The Affiliated Hospital of Medical College, Qingdao University, 16 Jiangsu Road, 266003, Qingdao, People's Republic of China aut NATIONALLICENCE 700 1- Wang M. Department of Thoracic Surgery, The Affiliated Hospital of Medical College, Qingdao University, 16 Jiangsu Road, 266003, Qingdao, People's Republic of China aut NATIONALLICENCE 700 1- Wang Y. Department of Thoracic Surgery, The Affiliated Hospital of Medical College, Qingdao University, 16 Jiangsu Road, 266003, Qingdao, People's Republic of China aut NATIONALLICENCE 700 1- Luo Y. Department of Thoracic Surgery, The Affiliated Hospital of Medical College, Qingdao University, 16 Jiangsu Road, 266003, Qingdao, People's Republic of China aut NATIONALLICENCE 700 1- Zhao Y. Department of Thoracic Surgery, The Affiliated Hospital of Medical College, Qingdao University, 16 Jiangsu Road, 266003, Qingdao, People's Republic of China aut NATIONALLICENCE 700 1- Tang D. Department of Thoracic Surgery, The Affiliated Hospital of Medical College, Qingdao University, 16 Jiangsu Road, 266003, Qingdao, People's Republic of China aut NATIONALLICENCE 700 1- Shen Y. Department of Thoracic Surgery, The Affiliated Hospital of Medical College, Qingdao University, 16 Jiangsu Road, 266003, Qingdao, People's Republic of China aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/10(2013-10-01), 789-795 1699-048X 15:10<789 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer