naa a22 4500 51076388X CHVBK 20180411083149.0 cr unu---uuuuu 180411e20131001xx s 000 0 eng 10.1007/s12094-013-1041-1 doi (NATIONALLICENCE)springer-10.1007/s12094-013-1041-1 Ependymoma in children: molecular considerations and therapeutic insights [Elektronische Daten] [J.-H. Kim, Y. Huang, A. Griffin, P. Rajappa, J. Greenfield] A multi-modality approach that encompasses maximal surgical resection in combination with adjuvant therapy is critical for achieving optimal disease control in children with ependymoma. In view of its complex biology and variable response to therapy, ependymoma remains a challenge for clinicians involved in the care of these patients. Meanwhile, translation of molecular findings can characterize unique features of childhood ependymoma and their natural history. Furthermore, understanding the biology of pediatric ependymoma serves as a platform for development of future targeted therapies. In line with these goals, we review the molecular basis of pediatric ependymoma and its prognostic implications, as well as novel therapeutic advances in the management of ependymoma in children. Federación de Sociedades Españolas de Oncología (FESEO), 2013 Pediatric ependymoma nationallicence Molecular diagnostics nationallicence Targeted therapy nationallicence Superselective intra-arterial cerebral infusion nationallicence Kim J.-H Department of Neurological Surgery, Weill Cornell Medical College, 525 East 68th Street, Box 99, 10065, New York, NY, USA aut Huang Y. Department of Neurological Surgery, Weill Cornell Medical College, 525 East 68th Street, Box 99, 10065, New York, NY, USA aut Griffin A. Department of Neurological Surgery, Weill Cornell Medical College, 525 East 68th Street, Box 99, 10065, New York, NY, USA aut Rajappa P. Department of Neurological Surgery, Weill Cornell Medical College, 525 East 68th Street, Box 99, 10065, New York, NY, USA aut Greenfield J. Department of Neurological Surgery, Weill Cornell Medical College, 525 East 68th Street, Box 99, 10065, New York, NY, USA aut Clinical and Translational Oncology Springer Milan 15/10(2013-10-01), 759-765 1699-048X 15:10<759 2013 15 12094 https://doi.org/10.1007/s12094-013-1041-1 text/html Onlinezugriff via DOI 1 article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-013-1041-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim J.-H Department of Neurological Surgery, Weill Cornell Medical College, 525 East 68th Street, Box 99, 10065, New York, NY, USA aut NATIONALLICENCE 700 1- Huang Y. Department of Neurological Surgery, Weill Cornell Medical College, 525 East 68th Street, Box 99, 10065, New York, NY, USA aut NATIONALLICENCE 700 1- Griffin A. Department of Neurological Surgery, Weill Cornell Medical College, 525 East 68th Street, Box 99, 10065, New York, NY, USA aut NATIONALLICENCE 700 1- Rajappa P. Department of Neurological Surgery, Weill Cornell Medical College, 525 East 68th Street, Box 99, 10065, New York, NY, USA aut NATIONALLICENCE 700 1- Greenfield J. Department of Neurological Surgery, Weill Cornell Medical College, 525 East 68th Street, Box 99, 10065, New York, NY, USA aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/10(2013-10-01), 759-765 1699-048X 15:10<759 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer