naa a22 4500 51076391X CHVBK 20180411083149.0 cr unu---uuuuu 180411e20131001xx s 000 0 eng 10.1007/s12094-013-1004-6 doi (NATIONALLICENCE)springer-10.1007/s12094-013-1004-6 Profiles of circulating endothelial cells and serum cytokines during adjuvant chemoradiation in rectal cancer patients [Elektronische Daten] [C.-C. Lin, C.-Y. Liu, M.-J. Chen, T.-E. Wang, C.-H. Chu, H.-Y. Wang, S.-C. Shih, M.-L. Hsu, T.-C. Hsu, Y.-J. Chen] Introduction: This research aimed to demonstrate the correlation of circulating endothelial cells (CECs) count and serum cytokine levels with side effects and prognosis in rectal cancer patients receiving adjuvant chemoradiation. Methods: Eleven patients received proctectomy, chemoradiotherapy and follow-up for 4years. Fifty-five blood samples were taken before radiation and during the course. The quantities of CECs were estimated by flow cytometry, and serological factors were measured by ELISA. Results: The CEC level in patients without tumor recurrence was significantly lower than in patients with tumor recurrence (p<0.01). The IL-6 and TGF-β1 levels exhibited a similar profile (p<0.01). For morbidity, the mean CEC level in patients with grade 3 diarrhea was significantly greater than patients with grades 1 (p<0.001) and 2 diarrhea (p<0.005). Conclusions: Levels of CECs, serum IL-6, TGF-β1 and TNF-α during post-operative chemoradiation in rectal cancer patients might be candidate biomarkers for prognosis and morbidity (NCT00325871). Federación de Sociedades Españolas de Oncología (FESEO), 2013 Rectal cancer nationallicence Adjuvant chemoradiation nationallicence Circulating endothelial cell nationallicence Cytokine nationallicence Lin C.-C Division of Gastroenterology, Mackay Memorial Hospital, Taipei, Taiwan aut Liu C.-Y Division of Gastroenterology, Mackay Memorial Hospital, Taipei, Taiwan aut Chen M.-J Division of Gastroenterology, Mackay Memorial Hospital, Taipei, Taiwan aut Wang T.-E Division of Gastroenterology, Mackay Memorial Hospital, Taipei, Taiwan aut Chu C.-H Division of Gastroenterology, Mackay Memorial Hospital, Taipei, Taiwan aut Wang H.-Y Division of Gastroenterology, Mackay Memorial Hospital, Taipei, Taiwan aut Shih S.-C Division of Gastroenterology, Mackay Memorial Hospital, Taipei, Taiwan aut Hsu M.-L Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan aut Hsu T.-C Division of Colon and Rectal Surgery, Mackay Memorial Hospital, 92, Section2, Chung-Shan North Road, 104, Taipei, Taiwan aut Chen Y.-J Department of Medical Research and Radiation Oncology, Mackay Memorial Hospital, 92, Section2, Chung-Shan North Road, 104, Taipei, Taiwan aut Clinical and Translational Oncology Springer Milan 15/10(2013-10-01), 855-860 1699-048X 15:10<855 2013 15 12094 https://doi.org/10.1007/s12094-013-1004-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-013-1004-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lin C.-C Division of Gastroenterology, Mackay Memorial Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Liu C.-Y Division of Gastroenterology, Mackay Memorial Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Chen M.-J Division of Gastroenterology, Mackay Memorial Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Wang T.-E Division of Gastroenterology, Mackay Memorial Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Chu C.-H Division of Gastroenterology, Mackay Memorial Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Wang H.-Y Division of Gastroenterology, Mackay Memorial Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Shih S.-C Division of Gastroenterology, Mackay Memorial Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Hsu M.-L Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Hsu T.-C Division of Colon and Rectal Surgery, Mackay Memorial Hospital, 92, Section2, Chung-Shan North Road, 104, Taipei, Taiwan aut NATIONALLICENCE 700 1- Chen Y.-J Department of Medical Research and Radiation Oncology, Mackay Memorial Hospital, 92, Section2, Chung-Shan North Road, 104, Taipei, Taiwan aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/10(2013-10-01), 855-860 1699-048X 15:10<855 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer