naa a22 4500 510763952 CHVBK 20180411083149.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s12094-012-0927-7 doi (NATIONALLICENCE)springer-10.1007/s12094-012-0927-7 Dynamic regulation of cancer stem cells and clinical challenges [Elektronische Daten] [Chao Ni, Jian Huang] A small population of cancer cells referred to as cancer stem cells (CSCs) have received particular attention, as they have been revealed to acquire stem cell-like properties and become the main cause of tumor propagation, metastasis and drug resistance. The CSC theory of tumor formation was believed to follow the hierarchical model initially, and therefore many CSC-targeted therapy methods were expected to cure cancer by eradicating CSCs. However, subsequent CSC research has revealed that rather than a distinct entity, the CSC is a dynamic status that can be continually dedifferentiated from progenitor or differentiated cancer cells. Elucidation of this bidirectional transition mechanism would help perfect the CSC theory and be of great value in the development of more effective anti-cancer drugs. Here, we reviewed the mechanisms of reciprocal conversion between non-CSCs and CSCs. Moreover, several approaches of target CSCs and non-CSCs together with unbiased eradication of all cancer cells are also discussed. Federación de Sociedades Españolas de Oncología (FESEO), 2012 Cancer stem cells nationallicence Reprogramming nationallicence Dedifferentiation nationallicence Epigenetics nationallicence Microenvironment nationallicence Ni Chao Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education; Provincial Key Laboratory of Molecular Biology in Medical Sciences), The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, China aut Huang Jian Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education; Provincial Key Laboratory of Molecular Biology in Medical Sciences), The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, China aut Clinical and Translational Oncology Springer Milan 15/4(2013-04-01), 253-258 1699-048X 15:4<253 2013 15 12094 https://doi.org/10.1007/s12094-012-0927-7 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-012-0927-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ni Chao Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education; Provincial Key Laboratory of Molecular Biology in Medical Sciences), The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, China aut NATIONALLICENCE 700 1- Huang Jian Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education; Provincial Key Laboratory of Molecular Biology in Medical Sciences), The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, China aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/4(2013-04-01), 253-258 1699-048X 15:4<253 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer