naa a22 4500 510763979 CHVBK 20180411083149.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s12094-012-0914-z doi (NATIONALLICENCE)springer-10.1007/s12094-012-0914-z Tumor volume delineation in head and neck cancer with 18-fluor-fluorodeoxiglucose positron emission tomography: adaptive thresholding method applied to primary tumors and metastatic lymph nodes [Elektronische Daten] [Luis Perez-Romasanta, Maria Bellon-Guardia, Javier Torres-Donaire, Eva Lozano-Martin, Miguel Sanz-Martin, Joaquin Velasco-Jimenez] Purpose: There are several potential advantages of using 18-fluor-fluorodeoxiglucose (18F-FDG) PET for target volume contouring, but before PET-based gross tumor volumes (GTVs) can reliably and reproducibly be incorporated into high-precision radiotherapy planning, operator-independent segmentation tools have to be developed and validated. The purpose of the present work was to apply the adaptive to the signal/background ratio (RS/B) thresholding method for head and neck tumor delineation, and compare these GTVPET to reference GTVCT volumes in order to assess discrepancies. Materials and methods: A cohort of 19 patients (39 lesions) with a histological diagnosis of head and neck cancer who would undergo definitive concurrent radiochemotherapy or radical radiotherapy with intensity-modulated radiotherapy technique (IMRT), were enrolled in this prospective study. Contouring on PET images was accomplished through standardized uptake value (SUV)-threshold definition. The threshold value was adapted to RS/B. To determine the relationship between the threshold and the RS/B, we performed a phantom study. A discrepancy index (DI) between both imaging modalities, overlap fraction (OF) and mismatch fraction (MF) were calculated for each lesion and imaging modality. Results: The median DI value for lymph nodes was 2.67 and 1.76 for primary lesions. The OF values were larger for CT volumes than for PET volumes (p<0.001), for both types of lesions. The MF values were smaller for CT volumes than for PET volumes (p<0.001), for both types of lesions. The GTVPET coverage (OFPET) was strongly correlated with the lesion volume (GTVCT) for metastatic lymph nodes (Pearson correlation=0.665; p<0.01). For smaller lesions, despite the GTV volumes were relatively larger on PET than in CT contours, the coverage was poorer. Accordingly, the MFPET/CT was negatively correlated with the lesion volume for metastatic lymph nodes. Conclusions: The present study highlights the considerable challenges involved in using FDG PET imaging for the delineation of GTV in head and neck neoplasms. The methods that rely mainly on SUVmax for thresholding, as the RS/B method, are very sensitive to partial volume effects and may provide unreliable results when applied on small lesions. Federación de Sociedades Españolas de Oncología (FESEO), 2012 Head and neck cancer nationallicence 18F-FDG PET/CT nationallicence Radiotherapy planning nationallicence Target volume nationallicence Perez-Romasanta Luis Radiation Oncology, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain aut Bellon-Guardia Maria Nuclear Medicine, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain aut Torres-Donaire Javier Radiation Physics, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain aut Lozano-Martin Eva Radiation Oncology, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain aut Sanz-Martin Miguel Radiation Oncology, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain aut Velasco-Jimenez Joaquin Radiation Oncology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain aut Clinical and Translational Oncology Springer Milan 15/4(2013-04-01), 283-293 1699-048X 15:4<283 2013 15 12094 https://doi.org/10.1007/s12094-012-0914-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-012-0914-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Perez-Romasanta Luis Radiation Oncology, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain aut NATIONALLICENCE 700 1- Bellon-Guardia Maria Nuclear Medicine, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain aut NATIONALLICENCE 700 1- Torres-Donaire Javier Radiation Physics, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain aut NATIONALLICENCE 700 1- Lozano-Martin Eva Radiation Oncology, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain aut NATIONALLICENCE 700 1- Sanz-Martin Miguel Radiation Oncology, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain aut NATIONALLICENCE 700 1- Velasco-Jimenez Joaquin Radiation Oncology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/4(2013-04-01), 283-293 1699-048X 15:4<283 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer