naa a22 4500 510764002 CHVBK 20180411083150.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s12094-012-0907-y doi (NATIONALLICENCE)springer-10.1007/s12094-012-0907-y Hypofractionated helical tomotherapy using 2.5-2.6Gy daily fractions for localized prostate cancer [Elektronische Daten] [Jose Lopez Guerra, Nicolas Isa, Raul Matute, Moises Russo, Fernando Puebla, Michelle Kim, Alberto Sanchez-Reyes, Cesar Beltran, Javier Jaen, Celine Bourgier, Hugo Marsiglia] Background: The purpose of this study is to evaluate the tolerability of hypofractionated helical tomotherapy (HT) in the treatment of localized prostate cancer. Materials and methods: We evaluated 48 patients with primary adenocarcinoma of the prostate (cT1-T3N0M0) who were treated with hypofractionated HT from August 2008 through July 2011. Hypofractionated regimens included: 68.04Gy at 2.52Gy/fraction, 70Gy at 2.5Gy/fraction, and 70.2Gy at 2.6Gy/fraction. Genitourinary (GU) and gastrointestinal (GI) toxicity was scored using the Radiation Therapy Oncology Group scoring system. Results: Thirty-two patients were treated with 68.04Gy, 5 patients with 70Gy, and 11 with 70.2Gy. The median age at diagnosis was 69years (range 49-87) and the median follow-up 11months (range 7-40). Grade 2 acute GI toxicity occurred in 9 patients (19%). No grade 3 or higher acute GI toxicity was observed. Grade 2 and 3 acute GU toxicities occurred in 19 and 6% of patients, respectively. The incidence of late grade 2 GI and GU toxicity was 4 and 2%, respectively. No grade 3 or higher late toxicities were observed. Multivariate analysis showed that patients treated at 2.6Gy/fraction or those who received a total radiation dose ≥70Gy had higher rates of grade ≥2 acute GU toxicity (P=0.004 and P=0.048, respectively). Conclusion: Hypofractionated HT in the treatment of localized prostate cancer is well tolerated with no grade 3 or higher early or late GI and GU toxicities. Further research is needed to assess definitive late toxicity and tumor control. Federación de Sociedades Españolas de Oncología (FESEO), 2012 Helical tomotherapy nationallicence Prostate cancer nationallicence Hypofractionation nationallicence Outcome nationallicence Lopez Guerra Jose Department of Radiation Oncology, Instituto Madrileño de Oncología/Grupo IMO, Clinica La Milagrosa, Calle Modesto Lafuente, 14, 28010, Madrid, Spain aut Isa Nicolas Department of Radiation Oncology, Instituto Madrileño de Oncología/Grupo IMO, Clinica La Milagrosa, Calle Modesto Lafuente, 14, 28010, Madrid, Spain aut Matute Raul Department of Radiation Oncology, Instituto Madrileño de Oncología/Grupo IMO, Clinica La Milagrosa, Calle Modesto Lafuente, 14, 28010, Madrid, Spain aut Russo Moises Medical School, Diego Portales University, Santiago, Chile aut Puebla Fernando Department of Radiation Oncology, Instituto Madrileño de Oncología/Grupo IMO, Clinica La Milagrosa, Calle Modesto Lafuente, 14, 28010, Madrid, Spain aut Kim Michelle Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA aut Sanchez-Reyes Alberto Radiation Physics, Instituto Madrileño de Oncología/Grupo IMO, Madrid, Spain aut Beltran Cesar Department of Radiation Oncology, Instituto Madrileño de Oncología/Grupo IMO, Clinica La Milagrosa, Calle Modesto Lafuente, 14, 28010, Madrid, Spain aut Jaen Javier Department of Radiation Oncology, Instituto Madrileño de Oncología/Grupo IMO, Clinica La Milagrosa, Calle Modesto Lafuente, 14, 28010, Madrid, Spain aut Bourgier Celine Department of Radiation Oncology, Institut de cancérologie Gustave Roussy, Villejuif, Paris, France aut Marsiglia Hugo Department of Radiation Oncology, Instituto Madrileño de Oncología/Grupo IMO, Clinica La Milagrosa, Calle Modesto Lafuente, 14, 28010, Madrid, Spain aut Clinical and Translational Oncology Springer Milan 15/4(2013-04-01), 271-277 1699-048X 15:4<271 2013 15 12094 https://doi.org/10.1007/s12094-012-0907-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-012-0907-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lopez Guerra Jose Department of Radiation Oncology, Instituto Madrileño de Oncología/Grupo IMO, Clinica La Milagrosa, Calle Modesto Lafuente, 14, 28010, Madrid, Spain aut NATIONALLICENCE 700 1- Isa Nicolas Department of Radiation Oncology, Instituto Madrileño de Oncología/Grupo IMO, Clinica La Milagrosa, Calle Modesto Lafuente, 14, 28010, Madrid, Spain aut NATIONALLICENCE 700 1- Matute Raul Department of Radiation Oncology, Instituto Madrileño de Oncología/Grupo IMO, Clinica La Milagrosa, Calle Modesto Lafuente, 14, 28010, Madrid, Spain aut NATIONALLICENCE 700 1- Russo Moises Medical School, Diego Portales University, Santiago, Chile aut NATIONALLICENCE 700 1- Puebla Fernando Department of Radiation Oncology, Instituto Madrileño de Oncología/Grupo IMO, Clinica La Milagrosa, Calle Modesto Lafuente, 14, 28010, Madrid, Spain aut NATIONALLICENCE 700 1- Kim Michelle Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA aut NATIONALLICENCE 700 1- Sanchez-Reyes Alberto Radiation Physics, Instituto Madrileño de Oncología/Grupo IMO, Madrid, Spain aut NATIONALLICENCE 700 1- Beltran Cesar Department of Radiation Oncology, Instituto Madrileño de Oncología/Grupo IMO, Clinica La Milagrosa, Calle Modesto Lafuente, 14, 28010, Madrid, Spain aut NATIONALLICENCE 700 1- Jaen Javier Department of Radiation Oncology, Instituto Madrileño de Oncología/Grupo IMO, Clinica La Milagrosa, Calle Modesto Lafuente, 14, 28010, Madrid, Spain aut NATIONALLICENCE 700 1- Bourgier Celine Department of Radiation Oncology, Institut de cancérologie Gustave Roussy, Villejuif, Paris, France aut NATIONALLICENCE 700 1- Marsiglia Hugo Department of Radiation Oncology, Instituto Madrileño de Oncología/Grupo IMO, Clinica La Milagrosa, Calle Modesto Lafuente, 14, 28010, Madrid, Spain aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/4(2013-04-01), 271-277 1699-048X 15:4<271 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer