naa a22 4500 510764010 CHVBK 20180411083150.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s12094-012-0916-x doi (NATIONALLICENCE)springer-10.1007/s12094-012-0916-x Impact of radiotherapy delay on survival in glioblastoma [Elektronische Daten] [Izaskun Valduvieco, Eugènia Verger, Jordi Bruna, Lluís Caral, Teresa Pujol, Teresa Ribalta, Teresa Boget, Laura Oleaga, Estela Pineda, Francesc Graus] Background: Previous studies in glioblastoma have concluded that there is no decrease in survival with increasing time to initiation of RT up to 6weeks after surgery. Unfortunately, the number of glioblastoma patients who start RT beyond 6weeks is not small in some countries. The aim of our study was to evaluate the effect of RT delay beyond 6weeks on survival of patients who have undergone completed resection of a glioblastoma. Methods: We reviewed 107 consecutive glioblastoma patients who had a complete surgical resection at our hospital. Clinical data, including delay in initiation of RT, were prospectively collected. The impact of single parameters on overall survival was determined by univariate and multivariate analyses. Results: According to univariate analysis, variables that had a prognostic influence on survival were age (p=0.036), KPS (p=0.031), additional treatment with CHT (p<0.0001), and initiation of RT before 42days (p=0.009). Multivariate analysis indicated that Karnofsky performance scale, additional treatment with chemotherapy, and initiation of RT before 6weeks after surgery were favorable, independent prognostic factors of survival. Conclusions: Survival is significantly reduced in glioblastoma patients if RT is not initiated within the 6weeks after complete resection of the tumor. Federación de Sociedades Españolas de Oncología (FESEO), 2012 Glioblastoma nationallicence Delay of radiotherapy nationallicence Prognostic factors nationallicence Radiotherapy nationallicence Valduvieco Izaskun Radiation Oncology Service, Institute of Haematology and Oncology, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut Verger Eugènia Radiation Oncology Service, Institute of Haematology and Oncology, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut Bruna Jordi Functional Unit of Neuro-Oncology, Department of Neurology, Hospital Universitari de Bellvitge-ICO Duran i Reynals, University of Barcelona, L'Hospitalet, Spain aut Caral Lluís Neurosurgery Service, Institute of Neuroscience, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain aut Pujol Teresa Radiology Service, Imaging Diagnostic Center, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain aut Ribalta Teresa Pathology Service, Biomedical Diagnostic Center, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain aut Boget Teresa Neuropsychology Service, Institute of Neuroscience, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain aut Oleaga Laura Radiology Service, Imaging Diagnostic Center, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain aut Pineda Estela Medical Oncology Service, Institute of Haematology and Oncology, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain aut Graus Francesc Neurology Service, Institute of Neuroscience, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain aut Clinical and Translational Oncology Springer Milan 15/4(2013-04-01), 278-282 1699-048X 15:4<278 2013 15 12094 https://doi.org/10.1007/s12094-012-0916-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-012-0916-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Valduvieco Izaskun Radiation Oncology Service, Institute of Haematology and Oncology, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Verger Eugènia Radiation Oncology Service, Institute of Haematology and Oncology, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Bruna Jordi Functional Unit of Neuro-Oncology, Department of Neurology, Hospital Universitari de Bellvitge-ICO Duran i Reynals, University of Barcelona, L'Hospitalet, Spain aut NATIONALLICENCE 700 1- Caral Lluís Neurosurgery Service, Institute of Neuroscience, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Pujol Teresa Radiology Service, Imaging Diagnostic Center, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Ribalta Teresa Pathology Service, Biomedical Diagnostic Center, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Boget Teresa Neuropsychology Service, Institute of Neuroscience, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Oleaga Laura Radiology Service, Imaging Diagnostic Center, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Pineda Estela Medical Oncology Service, Institute of Haematology and Oncology, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Graus Francesc Neurology Service, Institute of Neuroscience, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/4(2013-04-01), 278-282 1699-048X 15:4<278 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer