naa a22 4500 51076407X CHVBK 20180411083150.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s12094-012-0925-9 doi (NATIONALLICENCE)springer-10.1007/s12094-012-0925-9 Competing causes of death in patients with locoregionally advanced head and neck cancer treated with concomitant boost radiation plus concurrent weekly cisplatin [Elektronische Daten] [Jaime Gómez-Millán, Maria Toledo, Yolanda Lupiañez, Antonio Rueda, Jose Trigo, Antonio Sachetti, Jose Medina] Background: This study analyzes the morbidity and the contribution of different causes of death to the outcome of patients with locally advanced head and- neck cancer after weekly cisplatin plus concomitant boost accelerated radiation treated in our center. Materials and methods: Ninety-four patients with locally advanced head and neck carcinoma were included in this phase II trial consisting of concomitant boost radiation plus concurrent weekly cisplatin. The 43 patients treated in our centered with long-term follow-up were analyzed. Patients received radiotherapy with a concomitant boost scheme (1.8Gy on days 1-40 and 1.5Gy boost on days 25-40 with a total dose of 72Gy) and concurrent cisplatin, 40mg/m2 weekly, for the first 4weeks. Results: Most patients (93%) received both radiation and complete chemotherapy according to protocol. Severe late toxicity presented were subcutaneous (5%), larynx (2%) and esophagous (5%). Grade I-II late toxicity included mainly xerostomy (30%), skin (16%) and mucosal (16%) toxicity. With a median follow-up of 95months (9-135), the median overall survival and progression-free survival were 26 and 19months, respectively (95% CI 1-52; and 95% CI 0-45); 60% of the patients died because of head and neck cancer and 12% of a second neoplasm, while 27% of non-cancer patients died. Conclusions: Patients with locoregionally advanced head and neck cancer treated with concomitant boost accelerated radiation plus chemotherapy show significant risks of mortality from causes other than disease progression. Federación de Sociedades Españolas de Oncología (FESEO), 2012 Head and neck cancer nationallicence Late toxicity nationallicence Accelerated radiation nationallicence Concomitant boost radiation nationallicence Gómez-Millán Jaime Radiation Oncology Department, Hospital Clinico Universitario Virgen de la Victoria, Campus Teatinos s/n, 29010, Málaga, Spain aut Toledo Maria Radiation Oncology Department, Hospital Clinico Universitario Virgen de la Victoria, Campus Teatinos s/n, 29010, Málaga, Spain aut Lupiañez Yolanda Radiation Oncology Department, Hospital Clinico Universitario Virgen de la Victoria, Campus Teatinos s/n, 29010, Málaga, Spain aut Rueda Antonio Medical Oncology Department, Hospital Costa del Sol Marbella, Málaga, Spain aut Trigo Jose Medical Oncology Department, Hospital Clinico Universitario Virgen de la Victoria, Campus Teatinos s/n, 29010, Málaga, Spain aut Sachetti Antonio Radiation Oncology Department Centro radio-oncológico andaluz (CROASA), Málaga, Spain aut Medina Jose Radiation Oncology Department, Hospital Clinico Universitario Virgen de la Victoria, Campus Teatinos s/n, 29010, Málaga, Spain aut Clinical and Translational Oncology Springer Milan 15/4(2013-04-01), 321-326 1699-048X 15:4<321 2013 15 12094 https://doi.org/10.1007/s12094-012-0925-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-012-0925-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gómez-Millán Jaime Radiation Oncology Department, Hospital Clinico Universitario Virgen de la Victoria, Campus Teatinos s/n, 29010, Málaga, Spain aut NATIONALLICENCE 700 1- Toledo Maria Radiation Oncology Department, Hospital Clinico Universitario Virgen de la Victoria, Campus Teatinos s/n, 29010, Málaga, Spain aut NATIONALLICENCE 700 1- Lupiañez Yolanda Radiation Oncology Department, Hospital Clinico Universitario Virgen de la Victoria, Campus Teatinos s/n, 29010, Málaga, Spain aut NATIONALLICENCE 700 1- Rueda Antonio Medical Oncology Department, Hospital Costa del Sol Marbella, Málaga, Spain aut NATIONALLICENCE 700 1- Trigo Jose Medical Oncology Department, Hospital Clinico Universitario Virgen de la Victoria, Campus Teatinos s/n, 29010, Málaga, Spain aut NATIONALLICENCE 700 1- Sachetti Antonio Radiation Oncology Department Centro radio-oncológico andaluz (CROASA), Málaga, Spain aut NATIONALLICENCE 700 1- Medina Jose Radiation Oncology Department, Hospital Clinico Universitario Virgen de la Victoria, Campus Teatinos s/n, 29010, Málaga, Spain aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/4(2013-04-01), 321-326 1699-048X 15:4<321 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer