naa a22 4500 510764096 CHVBK 20180411083150.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s12094-012-0975-z doi (NATIONALLICENCE)springer-10.1007/s12094-012-0975-z The clinical implication of tumoral Gal-1 expression in laryngeal squamous cell carcinomas [Elektronische Daten] [J. Ye, H. Liu, Y. Hu, G. Wan, J. Li, Z. Wang, P. Li, G. Zhang, Y. Li] Purpose: To explore the expression of tumoral Gal-1 in association with clinical parameters and outcome in a large population with laryngeal squamous cell carcinomas (LSCCs). Methods: A total of 187 patients with LSCC were retrospectively enrolled. Immunohistochemistry was performed to evaluate the tumoral expression of Gal-1, apoptosis-related proteins and the density of tumor infiltrating lymphocytes (TILs) in tumor tissues before any intervene. Survival curves were estimated by the Kaplan-Meier method, and differences in survival between groups were determined using the log-rank test. Prognostic effects were evaluated by Cox regression analysis. Results: A total of 102 carcinomas (54.5%) were identified as high Gal-1 expression, and 85 carcinomas (45.5%) as low expression. Tumoral Gal-1 expression was not significantly related with clinical stage and histology differentiation. No correlation of Gal-1 expression with apoptosis-related protein was identified. Instead, Gal-1 status was correlated positively with the ratio of FOXP3+/CD8+ TILs (P=0.024). In multivariate regression analysis, advanced clinical stage and the presence of metastases were identified as the independent predictors for poor survival in entire cohort. Especially, the statistical correlation between the Gal-1 expression and prognosis was particularly due to the late-stage tumors (P<0.05). Conclusion: Current results represent valuable advancements in Gal-1 research and provided further support for using Gal-1 as a diagnostic biomarker and immunotherapeutic target for LSCC. Federación de Sociedades Españolas de Oncología (FESEO), 2013 Apoptosis nationallicence Galectin nationallicence Laryngeal squamous cell carcinomas nationallicence Prognosis nationallicence Tumor infiltrating lymphocytes nationallicence DFS : Disease-free survival nationallicence FOXP3 : Forkhead box P3 nationallicence HPF : High-power field nationallicence HNSCC : Head and neck squamous cell carcinomas nationallicence IHC : Immunohistochemistry nationallicence LSCCs : Laryngeal squamous cell carcinomas nationallicence NPC : Nasopharyngeal carcinoma nationallicence OS : Overall survival nationallicence PL : Partial laryngectomy nationallicence RC : Radiochemotherapy nationallicence SCCs : Squamous cell carcinomas nationallicence TIL : Tumor infiltrating lymphocytes nationallicence TL : Total laryngectomy nationallicence Treg : Regulatory T lymphocytes nationallicence Ye J. Department of Otolaryngology, Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe Street, 510630, Guangzhou, Guangdong, China aut Liu H. Division of Pulmonary and Critical Care, Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe street, 510630, Guangzhou, Guangdong, China aut Hu Y. Department of Otolaryngology, Head and Neck Surgery, Anhui Provincial Hospital, No. 17, Lujiang Street, 230001, Hefei, Anhui, China aut Wan G. Department of Otolaryngology, Head and Neck Surgery, Anhui Provincial Hospital, No. 17, Lujiang Street, 230001, Hefei, Anhui, China aut Li J. Department of Otolaryngology, Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe Street, 510630, Guangzhou, Guangdong, China aut Wang Z. Department of Otolaryngology, Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe Street, 510630, Guangzhou, Guangdong, China aut Li P. Department of Otolaryngology, Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe Street, 510630, Guangzhou, Guangdong, China aut Zhang G. Department of Otolaryngology, Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe Street, 510630, Guangzhou, Guangdong, China aut Li Y. Department of Otolaryngology, Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe Street, 510630, Guangzhou, Guangdong, China aut Clinical and Translational Oncology Springer Milan 15/8(2013-08-01), 608-618 1699-048X 15:8<608 2013 15 12094 https://doi.org/10.1007/s12094-012-0975-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-012-0975-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ye J. Department of Otolaryngology, Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe Street, 510630, Guangzhou, Guangdong, China aut NATIONALLICENCE 700 1- Liu H. Division of Pulmonary and Critical Care, Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe street, 510630, Guangzhou, Guangdong, China aut NATIONALLICENCE 700 1- Hu Y. Department of Otolaryngology, Head and Neck Surgery, Anhui Provincial Hospital, No. 17, Lujiang Street, 230001, Hefei, Anhui, China aut NATIONALLICENCE 700 1- Wan G. Department of Otolaryngology, Head and Neck Surgery, Anhui Provincial Hospital, No. 17, Lujiang Street, 230001, Hefei, Anhui, China aut NATIONALLICENCE 700 1- Li J. Department of Otolaryngology, Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe Street, 510630, Guangzhou, Guangdong, China aut NATIONALLICENCE 700 1- Wang Z. Department of Otolaryngology, Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe Street, 510630, Guangzhou, Guangdong, China aut NATIONALLICENCE 700 1- Li P. Department of Otolaryngology, Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe Street, 510630, Guangzhou, Guangdong, China aut NATIONALLICENCE 700 1- Zhang G. Department of Otolaryngology, Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe Street, 510630, Guangzhou, Guangdong, China aut NATIONALLICENCE 700 1- Li Y. Department of Otolaryngology, Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe Street, 510630, Guangzhou, Guangdong, China aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/8(2013-08-01), 608-618 1699-048X 15:8<608 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer