naa a22 4500 51076410X CHVBK 20180411083150.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s12094-012-0974-0 doi (NATIONALLICENCE)springer-10.1007/s12094-012-0974-0 Three or four fractions per week in postoperative high-dose-rate brachytherapy for endometrial carcinoma. The long-term results on vaginal relapses and toxicity [Elektronische Daten] [I. Valduvieco, Á. Rovirosa, A. Herreros, I. Romera, I. Ríos, C. Ascaso, A. Sánchez-Reyes, M. Arenas, J. Pahisa, A. Biete] Background: High-dose-rate brachytherapy (HDR-BT) is an accepted part of treatment for endometrial carcinoma and is usually performed in 1-2 fractions per week using different total doses and doses per fraction. To reduce the overall treatment time, HDR-BT was administered with a 3-4days/week schedule. Patients and methods: From June 2003 to December 2008, 164 patients with stage I-IIIc endometrial carcinoma were treated with HDR-BT (4-5Gy per fraction). The patients were divided into two groups; Group 1 (40/164 patients) was treated with HDR-BT alone (6 fractions; 4 fractions/week) and Group 2 (124/164 patients) was treated with both (External Beam Radiotherapy [EBRT]+HDR-BT: 3 fractions/week). Complications were analyzed using RTOG scores for rectum and bladder and the objective scores of LENT-SOMA for vaginal complications. Results: The mean followup was 48months. In Group 1, 35% of patients underwent treatment in ≤10days and 65% in >10days. In Group 2, 53.2% received treatment in ≤5days and in 46.8% in >5days. Vaginal relapse was observed in only two patients (1.2%), both having received adjuvant EBRT+HDR-BT. Acute vaginal toxicity appeared in 8.5% and late vaginal toxicity in 20.7% of patients with 13.4% being G1, 6.7% G2 and only 0.6% being G4. No statistically significant differences were found in complications in either brachytherapy group regardless of the overall time. Conclusion: In our series, three fractions given in 3-5/days after EBRT or six fractions in 10days, is a safe regimen in terms of complications and local control. Federación de Sociedades Españolas de Oncología (FESEO), 2012 Endometrial carcinoma nationallicence Brachytherapy nationallicence High-dose-rate nationallicence Postoperative radiotherapy nationallicence Valduvieco I. Radiation Oncology Department, Gynecologic Oncology Unit, Hospital Clínic, Institute of Haematology and Oncology (ICMHO), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut Rovirosa Á. Radiation Oncology Department, Gynecologic Oncology Unit, Hospital Clínic, Institute of Haematology and Oncology (ICMHO), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut Herreros A. Radiation Oncology Department, Gynecologic Oncology Unit, Hospital Clínic, Institute of Haematology and Oncology (ICMHO), Barcelona, Spain aut Romera I. Radiation Oncology Department, Gynecologic Oncology Unit, Hospital Clínic, Institute of Haematology and Oncology (ICMHO), Barcelona, Spain aut Ríos I. Radiation Oncology Department, Gynecologic Oncology Unit, Hospital Clínic, Institute of Haematology and Oncology (ICMHO), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut Ascaso C. Public Health Department, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain aut Sánchez-Reyes A. Radiation Oncology Department, Instituto Madrileño de Oncología. Grupo IMO, Madrid, Spain aut Arenas M. Radiation Oncology Department, Hospital Universitari Sant Joan de Reus, Reus, Tarragona, Spain aut Pahisa J. Gynecologic Oncology Unit, Gynecology Department, Hospital Clínic, Institute of Gynecology and Obstetrics (ICGON), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain aut Biete A. Radiation Oncology Department, Gynecologic Oncology Unit, Hospital Clínic, Institute of Haematology and Oncology (ICMHO), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut Clinical and Translational Oncology Springer Milan 15/8(2013-08-01), 602-607 1699-048X 15:8<602 2013 15 12094 https://doi.org/10.1007/s12094-012-0974-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-012-0974-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Valduvieco I. Radiation Oncology Department, Gynecologic Oncology Unit, Hospital Clínic, Institute of Haematology and Oncology (ICMHO), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Rovirosa Á. Radiation Oncology Department, Gynecologic Oncology Unit, Hospital Clínic, Institute of Haematology and Oncology (ICMHO), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Herreros A. Radiation Oncology Department, Gynecologic Oncology Unit, Hospital Clínic, Institute of Haematology and Oncology (ICMHO), Barcelona, Spain aut NATIONALLICENCE 700 1- Romera I. Radiation Oncology Department, Gynecologic Oncology Unit, Hospital Clínic, Institute of Haematology and Oncology (ICMHO), Barcelona, Spain aut NATIONALLICENCE 700 1- Ríos I. Radiation Oncology Department, Gynecologic Oncology Unit, Hospital Clínic, Institute of Haematology and Oncology (ICMHO), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Ascaso C. Public Health Department, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Sánchez-Reyes A. Radiation Oncology Department, Instituto Madrileño de Oncología. Grupo IMO, Madrid, Spain aut NATIONALLICENCE 700 1- Arenas M. Radiation Oncology Department, Hospital Universitari Sant Joan de Reus, Reus, Tarragona, Spain aut NATIONALLICENCE 700 1- Pahisa J. Gynecologic Oncology Unit, Gynecology Department, Hospital Clínic, Institute of Gynecology and Obstetrics (ICGON), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Biete A. Radiation Oncology Department, Gynecologic Oncology Unit, Hospital Clínic, Institute of Haematology and Oncology (ICMHO), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/8(2013-08-01), 602-607 1699-048X 15:8<602 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer