naa a22 4500 510764134 CHVBK 20180411083150.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s12094-012-0986-9 doi (NATIONALLICENCE)springer-10.1007/s12094-012-0986-9 Do comorbidity influences acute toxicity and outcome in elderly patients with endometrial cancer treated by adjuvant radiotherapy plus brachytherapy? [Elektronische Daten] [A. Fiorentino, C. Chiumento, V. Fusco] Purpose: To correlate comorbidity and acute radiation toxicity in elderly patients treated with adjuvant external beam radiotherapy (EBRT) plus brachytherapy-high dose rate (HDR-BRT) for endometrial cancer (EC). Methods: Endometrial cancer patients over 65 were treated and evaluated for comorbidity assessment with ACE-27 and Charlson comorbidity index (CCI). EBRT total dose was 45-50.4Gy (1.8Gy/day). The vault vagina boost of dose was performed by HDR-BRT with 2/3 fractions with a total dose of 10-15Gy. Results: From 2008 to 2011, 35 patients were analyzed. Eighteen patients (51.43%) had not ACE-27 comorbidity; while 27 patients (77.14%) had CCI lower than three. During treatment, acute toxicity was mild and not influenced by the comorbidity score. Two-year Progression Free and Overall Survival were 69 and 80%. ACE-27 and CCI did not affect progression-free survival (p=0.51, p=0.3) and OS (p=0.26, p=0.5). Conclusion: External beam radiotherapy plus BRT-HDR are well tolerated in EC elderly with good performance status and low comorbidity profile. Federación de Sociedades Españolas de Oncología (FESEO), 2013 Endometrial cancer nationallicence Comorbidity nationallicence Acute toxicity nationallicence Radiotherapy nationallicence Brachytherapy nationallicence Fiorentino A. Department of Radiation Oncology, IRCCS-CROB, Via S. Pio 1, 85028, Rionero in Vulture, PZ, Italy aut Chiumento C. Department of Radiation Oncology, IRCCS-CROB, Via S. Pio 1, 85028, Rionero in Vulture, PZ, Italy aut Fusco V. Department of Radiation Oncology, IRCCS-CROB, Via S. Pio 1, 85028, Rionero in Vulture, PZ, Italy aut Clinical and Translational Oncology Springer Milan 15/8(2013-08-01), 665-669 1699-048X 15:8<665 2013 15 12094 https://doi.org/10.1007/s12094-012-0986-9 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-012-0986-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fiorentino A. Department of Radiation Oncology, IRCCS-CROB, Via S. Pio 1, 85028, Rionero in Vulture, PZ, Italy aut NATIONALLICENCE 700 1- Chiumento C. Department of Radiation Oncology, IRCCS-CROB, Via S. Pio 1, 85028, Rionero in Vulture, PZ, Italy aut NATIONALLICENCE 700 1- Fusco V. Department of Radiation Oncology, IRCCS-CROB, Via S. Pio 1, 85028, Rionero in Vulture, PZ, Italy aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/8(2013-08-01), 665-669 1699-048X 15:8<665 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer