naa a22 4500 510764150 CHVBK 20180411083150.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s12094-012-0988-7 doi (NATIONALLICENCE)springer-10.1007/s12094-012-0988-7 Unsuspected gallbladder carcinoma discovered during or after cholecystectomy: focus on appropriate radical re-resection according to the T-stage [Elektronische Daten] [X. Yi, X. Long, H. Zai, D. Xiao, W. Li, Y. Li] Background: The long-term survival of patients with unsuspected gallbladder carcinoma (UGC) and the role of radical re-resection for this disease remain unclear. Methods: A retrospective study was carried out on 38 UGC patients. The time-to-event data were demonstrated by Kaplan-Meier curves. Comparing survival curves of two groups using the log-rank test. Results: The overall incidence of UGC in patients underwent cholecystectomy in our hospital was 0.18% (25 of 14,073). Distribution according to actual pT-stage (the UICC) was: pT1a: n=3; pT1b: n=11; pT2: n=4; pT3: n=12; pT4: n=8. The preoperative diagnosis included a high rate of acute biliary tract inflammation (24 of 38, 63.2%). Compared with other gallbladder carcinoma patients, UGC group had significantly higher proportion of early stages (pT1) (36.8%, 14 of 38 cases) (p<0.01), and better prognosis. The comparison of radical re-resection versus simple cholecystectomy showed a significant benefit in overall survival for the pT3 group (22.0±5.48 vs. 5.0±0.9months; p=0.02). There are median survival differences between the two subgroups of patients with pT1b tumors whether received re-resection or not. Median survival was 62.0months and 24.0±8.5months, respectively, though the differences are not statistically significant (p=0.131). Conclusion: Radical re-resection is strongly recommended for patients with pT1b-stage cancer. The reoperation should be performed as soon as possible, preferably within 10days after the initial operation. Federación de Sociedades Españolas de Oncología (FESEO), 2012 Cholecystectomy nationallicence Unsuspected gallbladder carcinoma nationallicence Radical re-resection nationallicence Prognosis nationallicence Yi X. Department of Radiology, Xiangya Hospital, Central South University, 410008, Changsha, China aut Long X. Department of Radiology, Xiangya Hospital, Central South University, 410008, Changsha, China aut Zai H. Department of General Surgery, Xiangya Hospital, Central South University, 88# Xiang Ya Road, 410008, Changsha, Hunan, China aut Xiao D. Department of Pathology, Xiangya Hospital, Central South University, 410008, Changsha, China aut Li W. Department of Radiology, Xiangya Hospital, Central South University, 410008, Changsha, China aut Li Y. Department of General Surgery, Xiangya Hospital, Central South University, 88# Xiang Ya Road, 410008, Changsha, Hunan, China aut Clinical and Translational Oncology Springer Milan 15/8(2013-08-01), 652-658 1699-048X 15:8<652 2013 15 12094 https://doi.org/10.1007/s12094-012-0988-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-012-0988-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yi X. Department of Radiology, Xiangya Hospital, Central South University, 410008, Changsha, China aut NATIONALLICENCE 700 1- Long X. Department of Radiology, Xiangya Hospital, Central South University, 410008, Changsha, China aut NATIONALLICENCE 700 1- Zai H. Department of General Surgery, Xiangya Hospital, Central South University, 88# Xiang Ya Road, 410008, Changsha, Hunan, China aut NATIONALLICENCE 700 1- Xiao D. Department of Pathology, Xiangya Hospital, Central South University, 410008, Changsha, China aut NATIONALLICENCE 700 1- Li W. Department of Radiology, Xiangya Hospital, Central South University, 410008, Changsha, China aut NATIONALLICENCE 700 1- Li Y. Department of General Surgery, Xiangya Hospital, Central South University, 88# Xiang Ya Road, 410008, Changsha, Hunan, China aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/8(2013-08-01), 652-658 1699-048X 15:8<652 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer