naa a22 4500 510764169 CHVBK 20180411083150.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s12094-012-0978-9 doi (NATIONALLICENCE)springer-10.1007/s12094-012-0978-9 The expression of Nek7, FoxM1, and Plk1 in gallbladder cancer and their relationships to clinicopathologic features and survival [Elektronische Daten] [R. Wang, Y. Song, X. Xu, Q. Wu, C. Liu] Purpose: Gallbladder carcinoma (GC) is generally considered as a relatively rare malignancy with poor prognosis. In order to guide clinicians in selecting suitable treatment for GC patients, reliable markers predictive of poor clinical outcome are desirable. This study analyzed the expression of Polo-like kinase 1 (Plk1), Nima related kinases 7 (Nek7) and Forkhead box M1 (FoxM1) in GC tissues and their relationship to clinicopathologic features and survival. Methods: We immunohistochemically investigated the 76 specimens of gallbladder carcinoma, pericarcinoma and normal tissues using Nek7, FoxM1 and Plk1 antibodies and analyzed the overall survival time of these 76 patients. Results: There were significant correlations between the high level expression of Nek7, FoxM1 and Plk1 and the tumor differentiation, Nevin staging and metastasis. The high level expression of Nek7, FoxM1 and Plk1 was significantly associated with shorter overall survival time in univariate analysis (log-rank test), also identified as an independent prognostic factor in multivariate analysis. Conclusion: Nek7, FoxM1 and Plk1 were significantly associated with certain clinicopathologic indices in GC. Evaluation of Nek7, FoxM1 and Plk1 expression may be an important factor in identifying a group of poor GC prognosis. Federación de Sociedades Españolas de Oncología (FESEO), 2012 Gallbladder carcinoma nationallicence Clinical pathology nationallicence Molecular biomarker nationallicence Survival analysis nationallicence Wang R. Department of Hepatobiliary Surgery, The First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, 710061, Xi'an, Shaanxi Province, China aut Song Y. Department of Hepatobiliary Surgery, The First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, 710061, Xi'an, Shaanxi Province, China aut Xu X. Department of Hepatobiliary Surgery, The First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, 710061, Xi'an, Shaanxi Province, China aut Wu Q. Department of Thoracic Surgery, The First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, 710061, Xi'an, Shaanxi Province, China aut Liu C. Department of Hepatobiliary Surgery, The First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, 710061, Xi'an, Shaanxi Province, China aut Clinical and Translational Oncology Springer Milan 15/8(2013-08-01), 626-632 1699-048X 15:8<626 2013 15 12094 https://doi.org/10.1007/s12094-012-0978-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-012-0978-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang R. Department of Hepatobiliary Surgery, The First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, 710061, Xi'an, Shaanxi Province, China aut NATIONALLICENCE 700 1- Song Y. Department of Hepatobiliary Surgery, The First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, 710061, Xi'an, Shaanxi Province, China aut NATIONALLICENCE 700 1- Xu X. Department of Hepatobiliary Surgery, The First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, 710061, Xi'an, Shaanxi Province, China aut NATIONALLICENCE 700 1- Wu Q. Department of Thoracic Surgery, The First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, 710061, Xi'an, Shaanxi Province, China aut NATIONALLICENCE 700 1- Liu C. Department of Hepatobiliary Surgery, The First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, 710061, Xi'an, Shaanxi Province, China aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/8(2013-08-01), 626-632 1699-048X 15:8<626 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer