naa a22 4500 510764177 CHVBK 20180411083150.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s12094-013-1003-7 doi (NATIONALLICENCE)springer-10.1007/s12094-013-1003-7 Radiosensitization by gold nanoparticles [Elektronische Daten] [B. Jeremic, A. Aguerri, N. Filipovic] Recent years brought increasing use of gold nano particles (GNP) as a model platform for interaction of irradiation and GNPs aiming radiosensitization. Endocytosis seems to be one of the major pathways for cellular uptake of GNPs. Internalization mechanism of GNPs is likely receptor-mediated endocytosis, influenced by GNP size, shape, its coating and surface charging. Many showed that DNA damage can occur as a consequence of metal-enhanced production of low energy electrons, Auger electrons and alike. Kilovoltage radiotherapy (RT) carries significantly higher dose enhancement factor (DEF) that is observed with megavoltage irradiations, the latter usually been at the order of 1.1-1.2. Higher gold concentrations seem to carry higher risk of toxicity, while with lower concentrations the DEF can be reduced. Adding a chemotherapeutic agent could increase level of enhancement. Clinical trials are eagerly awaited with a promise of gaining more knowledge deemed necessary for more successful transition to widespread clinical practice. Federación de Sociedades Españolas de Oncología (FESEO), 2013 Gold nationallicence Nanoparticles nationallicence Radiation therapy nationallicence Radiosensitization nationallicence Jeremic B. BioIRC, Bioengineering R&D Centre, Prvoslava Stojanovica 6, 34000, Kragujevac, Serbia aut Aguerri A. Department of Radiation Oncology, Hospital Ramon y Cajal, Madrid, Spain aut Filipovic N. BioIRC, Bioengineering R&D Centre, Prvoslava Stojanovica 6, 34000, Kragujevac, Serbia aut Clinical and Translational Oncology Springer Milan 15/8(2013-08-01), 593-601 1699-048X 15:8<593 2013 15 12094 https://doi.org/10.1007/s12094-013-1003-7 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-013-1003-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jeremic B. BioIRC, Bioengineering R&D Centre, Prvoslava Stojanovica 6, 34000, Kragujevac, Serbia aut NATIONALLICENCE 700 1- Aguerri A. Department of Radiation Oncology, Hospital Ramon y Cajal, Madrid, Spain aut NATIONALLICENCE 700 1- Filipovic N. BioIRC, Bioengineering R&D Centre, Prvoslava Stojanovica 6, 34000, Kragujevac, Serbia aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/8(2013-08-01), 593-601 1699-048X 15:8<593 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer