naa a22 4500 510764266 CHVBK 20180411083151.0 cr unu---uuuuu 180411e20130501xx s 000 0 eng 10.1007/s12094-012-0939-3 doi (NATIONALLICENCE)springer-10.1007/s12094-012-0939-3 Prognostic significance of NSE mRNA in advanced NSCLC treated with gefitinib [Elektronische Daten] [Y. Wang, D. Tang, A. Sui, W. Jiao, Y. Luo, M. Wang, R. Yang, Z. Wang, Y. Shen] Purpose: Current knowledge of the prognostic biomarkers of advanced non-small cell lung cancer (NSCLC) treated with gefitinib is poor. NSE mRNA as a potential prognostic biomarker of the effectiveness of gefitinib treatment in NSCLC, especially in the Chinese population, needs to be further validated. Patients and Methods: We retrospectively reviewed 168 advanced NSCLC patients treated with gefitinib between May 2006 and July 2010. NSE mRNA was measured using quantitative RT-PCR analysis for correlation with the clinical outcomes. Results: We found that NSE mRNA expression was inversely correlated with sensitivity to gefitinib in NSCLC patients. Patients without elevated NSE mRNA had a more RR (CR+RR) 45.1% than elevated 18.9% (P=0.0005). Moreover, the time to progression was 6.0 versus 4.2months, respectively. Log-rank test was marginally significant (χ2=12.11, P=0.0007) and Cox multivariate analysis revealed that NSE mRNA (HR=3.076; 95% CI 1.943-4.870; P<0.0001) was an independent prognostic factor of NSCLC patients in the Chinese population. Conclusion: For NSCLC patients treated with gefitinib, patients without elevated NSE mRNA had a better prognosis than those with elevated NSE mRNA. Pretreatment NSE mRNA holds great potential as a prognostic biomarker in advanced NSCLC. Therefore, it is proposed that NSE mRNA should be routinely detected to screen patients who are more likely to benefit from gefitinib-based treatment. Federación de Sociedades Españolas de Oncología (FESEO), 2012 NSE mRNA nationallicence Prognosis nationallicence Non-small cell lung cancer (NSCLC) nationallicence Gefitinib nationallicence Wang Y. Thoracic Surgery of the Affiliated Hospital of Medical College Qingdao University, 16 Jiangsu Road, 266003, Qingdao, China aut Tang D. Thoracic Surgery of the Affiliated Hospital of Medical College Qingdao University, 16 Jiangsu Road, 266003, Qingdao, China aut Sui A. Central Laboratory of the Affiliated Hospital of Medical College Qingdao University, Qingdao, China aut Jiao W. Thoracic Surgery of the Affiliated Hospital of Medical College Qingdao University, 16 Jiangsu Road, 266003, Qingdao, China aut Luo Y. Thoracic Surgery of the Affiliated Hospital of Medical College Qingdao University, 16 Jiangsu Road, 266003, Qingdao, China aut Wang M. Thoracic Surgery of the Affiliated Hospital of Medical College Qingdao University, 16 Jiangsu Road, 266003, Qingdao, China aut Yang R. Thoracic Surgery of the Affiliated Hospital of Medical College Qingdao University, 16 Jiangsu Road, 266003, Qingdao, China aut Wang Z. Thoracic Surgery of the Affiliated Hospital of Medical College Qingdao University, 16 Jiangsu Road, 266003, Qingdao, China aut Shen Y. Thoracic Surgery of the Affiliated Hospital of Medical College Qingdao University, 16 Jiangsu Road, 266003, Qingdao, China aut Clinical and Translational Oncology Springer Milan 15/5(2013-05-01), 384-390 1699-048X 15:5<384 2013 15 12094 https://doi.org/10.1007/s12094-012-0939-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-012-0939-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Y. Thoracic Surgery of the Affiliated Hospital of Medical College Qingdao University, 16 Jiangsu Road, 266003, Qingdao, China aut NATIONALLICENCE 700 1- Tang D. Thoracic Surgery of the Affiliated Hospital of Medical College Qingdao University, 16 Jiangsu Road, 266003, Qingdao, China aut NATIONALLICENCE 700 1- Sui A. Central Laboratory of the Affiliated Hospital of Medical College Qingdao University, Qingdao, China aut NATIONALLICENCE 700 1- Jiao W. Thoracic Surgery of the Affiliated Hospital of Medical College Qingdao University, 16 Jiangsu Road, 266003, Qingdao, China aut NATIONALLICENCE 700 1- Luo Y. Thoracic Surgery of the Affiliated Hospital of Medical College Qingdao University, 16 Jiangsu Road, 266003, Qingdao, China aut NATIONALLICENCE 700 1- Wang M. Thoracic Surgery of the Affiliated Hospital of Medical College Qingdao University, 16 Jiangsu Road, 266003, Qingdao, China aut NATIONALLICENCE 700 1- Yang R. Thoracic Surgery of the Affiliated Hospital of Medical College Qingdao University, 16 Jiangsu Road, 266003, Qingdao, China aut NATIONALLICENCE 700 1- Wang Z. Thoracic Surgery of the Affiliated Hospital of Medical College Qingdao University, 16 Jiangsu Road, 266003, Qingdao, China aut NATIONALLICENCE 700 1- Shen Y. Thoracic Surgery of the Affiliated Hospital of Medical College Qingdao University, 16 Jiangsu Road, 266003, Qingdao, China aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/5(2013-05-01), 384-390 1699-048X 15:5<384 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer