naa a22 4500 510764282 CHVBK 20180411083151.0 cr unu---uuuuu 180411e20130501xx s 000 0 eng 10.1007/s12094-012-0941-9 doi (NATIONALLICENCE)springer-10.1007/s12094-012-0941-9 Circulating autoantibody to ABCC3 may be a potential biomarker for esophageal squamous cell carcinoma [Elektronische Daten] [Y. Cheng, J. Xu, J. Guo, Y. Jin, X. Wang, Q. Zhang, L. Liu] Purpose: There is an urgent need to identify biomarkers for early diagnosis and prognosis of esophageal cancer. The present study was undertaken to test whether circulating autoantibodies to ATP-binding cassette C3 (ABCC3) transporter could serve as a biomarker for the malignant tumor. Methods: An enzyme-linked immunosorbent assay approach was developed in-house to test circulating autoantibodies to ABCC3 in 114 patients with esophageal squamous cell carcinoma (ESCC) and 226 healthy subjects well matched in age and smoking history. Results: Mann-Whitney U test showed that the IgA antibody levels were significantly higher in patients with ESCC than control subjects (Z=−4.226, P<0.001) while the IgG antibody levels were not significantly different between the two groups (Z=−1.072, P=0.284). The sensitivity against >95% specificity was 13.2% for the IgA assay with an inter-assay deviation of 13.0 and 7.9% for the IgG assay with an inter-assay deviation of 9.4%. Conclusions: This work suggests that circulating IgA autoantibody to ABCC3 may be a potential biomarker for ESCC, which could be used for early diagnosis and prognosis of the malignant tumor. Federación de Sociedades Españolas de Oncología (FESEO), 2012 ABCC3 transporter nationallicence Autoantibodies nationallicence Biomarkers nationallicence ELISA nationallicence Tumor immunity nationallicence Esophageal carcinoma nationallicence Cheng Y. Biological Therapy Unit and Surgical Department, Second Clinical Hospital, Jilin University, 130034, Changchun, China aut Xu J. Biological Therapy Unit and Surgical Department, Second Clinical Hospital, Jilin University, 130034, Changchun, China aut Guo J. Biological Therapy Unit and Surgical Department, Second Clinical Hospital, Jilin University, 130034, Changchun, China aut Jin Y. Biological Therapy Unit and Surgical Department, Second Clinical Hospital, Jilin University, 130034, Changchun, China aut Wang X. Biological Therapy Unit and Surgical Department, Second Clinical Hospital, Jilin University, 130034, Changchun, China aut Zhang Q. Biological Therapy Unit and Surgical Department, Second Clinical Hospital, Jilin University, 130034, Changchun, China aut Liu L. Biological Therapy Unit and Surgical Department, Second Clinical Hospital, Jilin University, 130034, Changchun, China aut Clinical and Translational Oncology Springer Milan 15/5(2013-05-01), 398-402 1699-048X 15:5<398 2013 15 12094 https://doi.org/10.1007/s12094-012-0941-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-012-0941-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cheng Y. Biological Therapy Unit and Surgical Department, Second Clinical Hospital, Jilin University, 130034, Changchun, China aut NATIONALLICENCE 700 1- Xu J. Biological Therapy Unit and Surgical Department, Second Clinical Hospital, Jilin University, 130034, Changchun, China aut NATIONALLICENCE 700 1- Guo J. Biological Therapy Unit and Surgical Department, Second Clinical Hospital, Jilin University, 130034, Changchun, China aut NATIONALLICENCE 700 1- Jin Y. Biological Therapy Unit and Surgical Department, Second Clinical Hospital, Jilin University, 130034, Changchun, China aut NATIONALLICENCE 700 1- Wang X. Biological Therapy Unit and Surgical Department, Second Clinical Hospital, Jilin University, 130034, Changchun, China aut NATIONALLICENCE 700 1- Zhang Q. Biological Therapy Unit and Surgical Department, Second Clinical Hospital, Jilin University, 130034, Changchun, China aut NATIONALLICENCE 700 1- Liu L. Biological Therapy Unit and Surgical Department, Second Clinical Hospital, Jilin University, 130034, Changchun, China aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/5(2013-05-01), 398-402 1699-048X 15:5<398 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer