naa a22 4500 510764304 CHVBK 20180411083151.0 cr unu---uuuuu 180411e20130501xx s 000 0 eng 10.1007/s12094-012-0938-4 doi (NATIONALLICENCE)springer-10.1007/s12094-012-0938-4 Advanced or metastatic gastric cancer in elderly patients: clinicopathological, prognostic factors and treatments [Elektronische Daten] [Z. Lu, M. Lu, X. Zhang, J. Li, J. Zhou, J. Gong, J. Gao, J. Li, X. Zhang, Y. Li, L. Shen] Purpose: To analyze the clinicopathological features, prognostic factors, treatment efficacy and safety among elderly patients with advanced or metastatic gastric cancer. Methods: Three hundred and nineteen patients aged 65years and older, diagnosed with advanced or metastatic gastric cancer, were followed and data were retrospectively collected, reviewed and analyzed. Results: The elderly patients carried specific clinicopathological characteristics. Body mass index (BMI), number of metastatic lesions, ascites, Karnofsky performance score (KPS), tumor differentiation grade, lactate dehydrogenase (LDH) level, local treatment, and chemotherapy were the independent prognostic factors. Serum LDH level was superior to the serum CEA level in the prognosis of advanced or metastatic gastric cancer in older patients. Cisplatin-based regimen, chemotherapy cycles, metastatic lesions, LDH level, and supraclavicular lymph node metastasis were the independent prognostic factors in 220 patients receiving chemotherapy. The toxicity was mild and tolerable. Conclusion: KPS, BMI and a well-differentiated histopathology were factors favoring longer survival, whereas elevated serum LDH and a greater number of metastatic lesions were associated with poor prognosis among those elderly patients. Cisplatin-based chemotherapy provided survival benefits and mild toxicity. Federación de Sociedades Españolas de Oncología (FESEO), 2012 Gastric cancer nationallicence Elderly nationallicence Chemotherapy nationallicence Survival nationallicence BMI : Body mass index nationallicence CEA : Carcinoembryonic antigen nationallicence CR : Complete response nationallicence 5-FU : 5-Fluorouracil nationallicence HR : Hazards ratio nationallicence KPS : Karnofsky performance score nationallicence LDH : Lactate dehydrogenase nationallicence PR : Partial response nationallicence SD : Stable disease nationallicence TTP : Time to progression nationallicence Lu Z. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of GI Oncology, Beijing Cancer Hospital and Institute, Peking University School of Oncology, 100142, Beijing, China aut Lu M. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of GI Oncology, Beijing Cancer Hospital and Institute, Peking University School of Oncology, 100142, Beijing, China aut Zhang X. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of GI Oncology, Beijing Cancer Hospital and Institute, Peking University School of Oncology, 100142, Beijing, China aut Li J. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of GI Oncology, Beijing Cancer Hospital and Institute, Peking University School of Oncology, 100142, Beijing, China aut Zhou J. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of GI Oncology, Beijing Cancer Hospital and Institute, Peking University School of Oncology, 100142, Beijing, China aut Gong J. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of GI Oncology, Beijing Cancer Hospital and Institute, Peking University School of Oncology, 100142, Beijing, China aut Gao J. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of GI Oncology, Beijing Cancer Hospital and Institute, Peking University School of Oncology, 100142, Beijing, China aut Li Y. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of GI Oncology, Beijing Cancer Hospital and Institute, Peking University School of Oncology, 100142, Beijing, China aut Shen L. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of GI Oncology, Beijing Cancer Hospital and Institute, Peking University School of Oncology, 100142, Beijing, China aut Clinical and Translational Oncology Springer Milan 15/5(2013-05-01), 376-383 1699-048X 15:5<376 2013 15 12094 https://doi.org/10.1007/s12094-012-0938-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-012-0938-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lu Z. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of GI Oncology, Beijing Cancer Hospital and Institute, Peking University School of Oncology, 100142, Beijing, China aut NATIONALLICENCE 700 1- Lu M. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of GI Oncology, Beijing Cancer Hospital and Institute, Peking University School of Oncology, 100142, Beijing, China aut NATIONALLICENCE 700 1- Zhang X. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of GI Oncology, Beijing Cancer Hospital and Institute, Peking University School of Oncology, 100142, Beijing, China aut NATIONALLICENCE 700 1- Li J. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of GI Oncology, Beijing Cancer Hospital and Institute, Peking University School of Oncology, 100142, Beijing, China aut NATIONALLICENCE 700 1- Zhou J. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of GI Oncology, Beijing Cancer Hospital and Institute, Peking University School of Oncology, 100142, Beijing, China aut NATIONALLICENCE 700 1- Gong J. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of GI Oncology, Beijing Cancer Hospital and Institute, Peking University School of Oncology, 100142, Beijing, China aut NATIONALLICENCE 700 1- Gao J. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of GI Oncology, Beijing Cancer Hospital and Institute, Peking University School of Oncology, 100142, Beijing, China aut NATIONALLICENCE 700 1- Li Y. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of GI Oncology, Beijing Cancer Hospital and Institute, Peking University School of Oncology, 100142, Beijing, China aut NATIONALLICENCE 700 1- Shen L. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of GI Oncology, Beijing Cancer Hospital and Institute, Peking University School of Oncology, 100142, Beijing, China aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/5(2013-05-01), 376-383 1699-048X 15:5<376 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer