naa a22 4500 510764320 CHVBK 20180411083151.0 cr unu---uuuuu 180411e20130501xx s 000 0 eng 10.1007/s12094-012-0937-5 doi (NATIONALLICENCE)springer-10.1007/s12094-012-0937-5 Expression analysis of tumor-related genes involved in critical regulatory pathways in schwannomas [Elektronische Daten] [Miguel Torres-Martín, Victor Martinez-Glez, Carolina Peña-Granero, Luis Lassaletta, Alberto Isla, Jose de Campos, Giovanny Pinto, Rommel Burbano, Bárbara Meléndez, Javier Castresana, Juan Rey] Purpose: Gene expression array analysis is providing key data on the potential candidate genes and biological pathways involved in schwannoma origin and development. In this way we performed expression array studies on tumor-related genes in schwannomas. Methods: The GE Array Q Series HS-006 (SuperArray, Bethesda, MD, USA) was used to determine the expression levels of 96 genes corresponding to 6 primary biological regulatory pathways in a series of 23 schwannomas. Results: We identified 15 genes down-regulated, primarily corresponding to signal transduction functions, and 26 genes up-regulated, most frequently involving cell adhesion functions. Conclusions: In addition to the NF2 inactivation (considered as an early step), variations of other biological regulatory pathways might play a key role in schwannoma. Federación de Sociedades Españolas de Oncología (FESEO), 2012 Schwannoma nationallicence NF2 nationallicence Gene expression arrays nationallicence Torres-Martín Miguel Unidad de Investigación, IdiPAz, Hospital Universitario La Paz, Paseo de la Castellana 261, 28046, Madrid, Spain aut Martinez-Glez Victor INGEMM, IdiPAZ, Hospital Universitario La Paz, Madrid, Spain aut Peña-Granero Carolina Unidad de Investigación, IdiPAz, Hospital Universitario La Paz, Paseo de la Castellana 261, 28046, Madrid, Spain aut Lassaletta Luis Departments of Otolaryngology and Neurosurgery, Hospital Universitario La Paz, Madrid, Spain aut Isla Alberto Departments of Otolaryngology and Neurosurgery, Hospital Universitario La Paz, Madrid, Spain aut de Campos Jose Department of Neurosurgery, Fundación Jiménez Díaz, Madrid, Spain aut Pinto Giovanny Genetics and Molecular Biology Laboratory, Federal University of Piauí, Parnaibá, Brazil aut Burbano Rommel Human Cytogenetics Laboratory, Federal University of Pará, Belem, Brazil aut Meléndez Bárbara Molecular Pathology Research Unit, Hospital virgin de la Salud, Toledo, Spain aut Castresana Javier Brain Tumor Biology Unit, University of Navarra, Pamplona, Spain aut Rey Juan Unidad de Investigación, IdiPAz, Hospital Universitario La Paz, Paseo de la Castellana 261, 28046, Madrid, Spain aut Clinical and Translational Oncology Springer Milan 15/5(2013-05-01), 409-411 1699-048X 15:5<409 2013 15 12094 https://doi.org/10.1007/s12094-012-0937-5 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-012-0937-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Torres-Martín Miguel Unidad de Investigación, IdiPAz, Hospital Universitario La Paz, Paseo de la Castellana 261, 28046, Madrid, Spain aut NATIONALLICENCE 700 1- Martinez-Glez Victor INGEMM, IdiPAZ, Hospital Universitario La Paz, Madrid, Spain aut NATIONALLICENCE 700 1- Peña-Granero Carolina Unidad de Investigación, IdiPAz, Hospital Universitario La Paz, Paseo de la Castellana 261, 28046, Madrid, Spain aut NATIONALLICENCE 700 1- Lassaletta Luis Departments of Otolaryngology and Neurosurgery, Hospital Universitario La Paz, Madrid, Spain aut NATIONALLICENCE 700 1- Isla Alberto Departments of Otolaryngology and Neurosurgery, Hospital Universitario La Paz, Madrid, Spain aut NATIONALLICENCE 700 1- de Campos Jose Department of Neurosurgery, Fundación Jiménez Díaz, Madrid, Spain aut NATIONALLICENCE 700 1- Pinto Giovanny Genetics and Molecular Biology Laboratory, Federal University of Piauí, Parnaibá, Brazil aut NATIONALLICENCE 700 1- Burbano Rommel Human Cytogenetics Laboratory, Federal University of Pará, Belem, Brazil aut NATIONALLICENCE 700 1- Meléndez Bárbara Molecular Pathology Research Unit, Hospital virgin de la Salud, Toledo, Spain aut NATIONALLICENCE 700 1- Castresana Javier Brain Tumor Biology Unit, University of Navarra, Pamplona, Spain aut NATIONALLICENCE 700 1- Rey Juan Unidad de Investigación, IdiPAz, Hospital Universitario La Paz, Paseo de la Castellana 261, 28046, Madrid, Spain aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/5(2013-05-01), 409-411 1699-048X 15:5<409 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer