naa a22 4500 510764355 CHVBK 20180411083151.0 cr unu---uuuuu 180411e20130201xx s 000 0 eng 10.1007/s12094-012-0887-y doi (NATIONALLICENCE)springer-10.1007/s12094-012-0887-y Multicenter validation of two nomograms to predict non-sentinel node involvement in breast cancer [Elektronische Daten] [Antonio Piñero, Manuel Canteras, Arancha Moreno, Francisco Vicente, Julia Giménez, Ana Tocino, Edelmiro Iglesias, Sergi Vidal-Sicart, Luzdivina Santamaría, Miguel Lorenzo, Manuel García, Diego Ramirez] Introduction: Nomograms are used to predict the involvement of non-sentinel nodes (nSN) in breast cancer. This study attempts to externally validate two of the more commonly used nomograms (MSKCC and Stanford University). Materials and methods: Five hundred and one cases of positive SNB with posterior axillary lymphadenectomy from 11 Spanish hospitals with widespread experience of the technique were studied. In all cases, an estimate of the probability of nSN involvement was made using the MSKCC and the Stanford University nomograms. Discrimination was assessed by calculating the area under the receiver operating characteristic curve. To assess the calibration of the nomogram, observed probability was plotted against the nomogram-calculated predicted probability. Results: The overall predictive accuracy of the MSKCC nomogram was 0.684 (95% confidence interval, 0.635-0.732), while in the case of that from Stanford the predictive accuracy was 0.658 (95% confidence interval 0.607-0.709). The mean predicted probability of nSN metastases in each group of patients was correlated with the observed probability with an acceptable concordance (r=0.820; p<0.004 in MSKCC nomogram and r=0.888; p<0.001 in Stanford nomogram). Conclusion: These nomograms can be useful tools in the evaluation of patients with breast cancer and positive sentinel nodes but other factors, including a comprehensive clinical assessment, must be used to decide the most appropriate surgical approach for an individual patient, especially with regard to avoiding unnecessary lymphadenectomy. Federación de Sociedades Españolas de Oncología (FESEO), 2012 Breast cancer nationallicence Nomograms nationallicence Sentinel node nationallicence Non-sentinel node nationallicence Piñero Antonio Department of General Surgery, Virgen de la Arrixaca University Hospital, 30120, Murcia, Spain aut Canteras Manuel Department of Biostatistics, School of Medicine, University of Murcia, Murcia, Spain aut Moreno Arancha Breast Unit, Department of Gynecology, Hospital Clínico San Carlos, Madrid, Spain aut Vicente Francisco Breast Unit, Department of General Surgery, Hospital de Navarra, Pamplona, Spain aut Giménez Julia Breast Unit, Instituto Valenciano de Oncología, Valencia, Spain aut Tocino Ana Breast Unit, Department of General Surgery, Puerta del Mar University Hospital, Cádiz, Spain aut Iglesias Edelmiro Breast Unit, Arnau de Vilanova University Hospital, Lérida, Spain aut Vidal-Sicart Sergi Department of Nuclear Medicine, Hospital Clínic, Barcelona, Spain aut Santamaría Luzdivina Breast Unit, Department of General Surgery, Hospital de Cabueñes, Gijón, Spain aut Lorenzo Miguel Department of General Surgery, Hospital Torrecárdenas, Almería, Spain aut García Manuel Department of Surgery, Complejo Hospitalario de Orense, Ourense, Spain aut Ramirez Diego Breast Unit, Hospital Comarcal de Huércal-Overa, Almería, Spain aut Clinical and Translational Oncology Springer Milan 15/2(2013-02-01), 117-123 1699-048X 15:2<117 2013 15 12094 https://doi.org/10.1007/s12094-012-0887-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-012-0887-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Piñero Antonio Department of General Surgery, Virgen de la Arrixaca University Hospital, 30120, Murcia, Spain aut NATIONALLICENCE 700 1- Canteras Manuel Department of Biostatistics, School of Medicine, University of Murcia, Murcia, Spain aut NATIONALLICENCE 700 1- Moreno Arancha Breast Unit, Department of Gynecology, Hospital Clínico San Carlos, Madrid, Spain aut NATIONALLICENCE 700 1- Vicente Francisco Breast Unit, Department of General Surgery, Hospital de Navarra, Pamplona, Spain aut NATIONALLICENCE 700 1- Giménez Julia Breast Unit, Instituto Valenciano de Oncología, Valencia, Spain aut NATIONALLICENCE 700 1- Tocino Ana Breast Unit, Department of General Surgery, Puerta del Mar University Hospital, Cádiz, Spain aut NATIONALLICENCE 700 1- Iglesias Edelmiro Breast Unit, Arnau de Vilanova University Hospital, Lérida, Spain aut NATIONALLICENCE 700 1- Vidal-Sicart Sergi Department of Nuclear Medicine, Hospital Clínic, Barcelona, Spain aut NATIONALLICENCE 700 1- Santamaría Luzdivina Breast Unit, Department of General Surgery, Hospital de Cabueñes, Gijón, Spain aut NATIONALLICENCE 700 1- Lorenzo Miguel Department of General Surgery, Hospital Torrecárdenas, Almería, Spain aut NATIONALLICENCE 700 1- García Manuel Department of Surgery, Complejo Hospitalario de Orense, Ourense, Spain aut NATIONALLICENCE 700 1- Ramirez Diego Breast Unit, Hospital Comarcal de Huércal-Overa, Almería, Spain aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/2(2013-02-01), 117-123 1699-048X 15:2<117 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer